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Overview

Welcome to Dwaey, specifically on CONDROTIDE PLUS page.
This medicine contains an important and useful components, as it consists of
Polynucleotides, Sodium hyaluronateis available in the market in concentration

Name

Naproxen 10% Topical

Precaution

Before using **Naproxen 10% Topical** (a topical formulation), it is crucial to consult a healthcare provider, especially if any of the following apply: - **Allergic reactions**: Individuals with a known allergy to **Naproxen**, **NSAIDs**, or any of the ingredients in the topical formulation should avoid use. Symptoms of an allergic reaction may include **rash**, **itching**, or **swelling** in the affected area. - **Skin conditions**: The medication should not be applied to broken, irritated, or infected skin. It may cause **skin irritation** or **increased sensitivity** in individuals with conditions like **eczema** or **psoriasis**. - **Pregnancy and breastfeeding**: Although **topical Naproxen** is less likely to cause systemic side effects compared to oral formulations, it should still be used cautiously during **pregnancy**, particularly in the **third trimester**, and **breastfeeding** women should seek medical advice before use, as the active ingredient could be absorbed through the skin. - **Avoid contact with eyes and mucous membranes**: It is important to avoid getting the medication in the eyes, mouth, or any mucous membranes, as it may cause irritation. - **Sun exposure**: The use of Naproxen 10% Topical may increase **sensitivity to sunlight**. Patients should limit sun exposure and use sunscreen while using this medication.

Indication

**Naproxen 10% Topical** is primarily used for the **local treatment of pain and inflammation**, particularly in conditions that affect muscles, joints, and soft tissues. The main indications include: - **Localized pain relief**: It is commonly used to relieve **musculoskeletal pain**, such as **back pain**, **shoulder pain**, and **knee pain**, particularly in conditions like **strains**, **sprains**, and **soft tissue injuries**. - **Arthritis**: It is beneficial for reducing pain and inflammation in conditions like **osteoarthritis** and **rheumatoid arthritis**, when localized relief is desired. - **Sports injuries**: Athletes or individuals with **sports injuries** (e.g., **tendinitis** or **bursitis**) may use this formulation to alleviate swelling, stiffness, and pain associated with overuse or acute injury. - **Other inflammatory conditions**: It can be used for **inflammatory conditions** of the soft tissues or joints that do not require systemic treatment.

Contra indication

Naproxen 10% Topical should not be used in the following situations: - **Hypersensitivity**: Individuals with a known allergy to **Naproxen**, other **NSAIDs**, or any of the product's ingredients should avoid use. Allergic reactions could range from mild skin irritation to severe **anaphylaxis**. - **Open wounds or broken skin**: The product should not be applied to areas of skin with **cuts**, **abrasions**, **eczema**, or **skin infections**, as this could lead to **irritation** or **infection** at the application site. - **Eye area**: It should not be applied near the **eyes** or any mucous membranes, as it could cause irritation or damage. - **Systemic NSAID contraindications**: Although topical, **Naproxen 10%** may still be contraindicated in individuals who have a history of **gastric ulcers**, **GI bleeding**, or **renal insufficiency**, particularly if they are sensitive to NSAIDs.

Side Effect

Common side effects of **Naproxen 10% Topical** include: - **Skin irritation**: It may cause **mild burning**, **stinging**, **itching**, or **redness** at the application site. This is generally transient and resolves after discontinuing use. - **Dry skin**: The area where the cream is applied may feel **dry** or become **flaky**. - **Rash**: Some patients may develop a **rash** or **itching** around the treated area. This is often mild but should be monitored for more severe reactions. Serious side effects are rare but include: - **Severe skin reactions**: In rare cases, **blistering**, **peeling**, or **severe rash** may occur, which may indicate an allergic reaction. Patients should discontinue use and seek medical attention immediately if these symptoms occur. - **Photosensitivity**: The medication may increase sensitivity to sunlight, causing the skin to burn more easily when exposed to UV light. It is recommended to avoid direct sunlight or use sun protection while applying the topical formulation. - **Systemic absorption**: Although rare, there is a risk of **systemic side effects** such as **headaches**, **dizziness**, or **stomach discomfort**, especially with **prolonged use** or when large areas of skin are treated.

Pregnancy Category ID

3

Mode of Action

**Naproxen 10% Topical** works similarly to its oral formulation by inhibiting the **cyclooxygenase (COX) enzymes** responsible for producing **prostaglandins**, which are mediators of **inflammation**, **pain**, and **fever**. - **COX-1** and **COX-2** are both involved in the production of prostaglandins in the body. By inhibiting these enzymes, Naproxen helps reduce the **pain**, **inflammation**, and **swelling** associated with conditions like arthritis, muscle strain, and soft tissue injury. - Since it is a **topical preparation**, it is designed for **local application** to areas of pain or inflammation, providing targeted relief with minimal systemic absorption. This makes it useful for localized conditions without significantly affecting the whole body.

Interaction

Naproxen 10% Topical has fewer systemic interactions compared to oral formulations, but caution is still advised when combined with the following: - **Other NSAIDs**: Using **topical Naproxen** in combination with other NSAIDs, including oral Naproxen or **ibuprofen**, increases the risk of **gastrointestinal irritation**, **ulcers**, or **bleeding**. Caution should be exercised to avoid excessive NSAID exposure. - **Anticoagulants**: Although absorption is limited, the **use of topical Naproxen** in combination with **blood thinners** like **warfarin** or **heparin** can increase the risk of **bleeding**, particularly if the skin barrier is compromised. - **Blood pressure medications**: There may be an increased risk of **fluid retention** and **elevated blood pressure** when topical Naproxen is used with **ACE inhibitors**, **ARBs**, or **diuretics**. - **Topical corticosteroids**: Using **topical Naproxen** with **topical steroids** on the same area of skin may increase the risk of **skin irritation** or **thinning**, and may also enhance the absorption of both drugs through the skin.

Pregnancy Category Note

Pregnancy category: C; D in 3rd trimester or near delivery.

Adult Dose

The recommended dose for **Naproxen 10% Topical** for adults is: - **Apply a thin layer** of the gel or cream to the affected area **2–3 times a day**. - **Massage gently** to allow absorption, but avoid excessive application to large areas of skin. The maximum recommended dose should not exceed the specified **daily amount** provided by the manufacturer.

Child Dose

For children, **Naproxen 10% Topical** should generally be avoided unless specifically prescribed by a healthcare provider. For children aged **12 years and older**, the recommended dose may be **similar to adults**, but the **dosage and frequency** should be adjusted based on the individual’s medical condition and the advice of a healthcare provider. Always consult a doctor before administering topical Naproxen to children. As with any medication, it is crucial to consult a healthcare provider to ensure appropriate use, especially in children or patients with other underlying medical conditions.

Renal Dose

For patients with **renal impairment**, the topical form of Naproxen may have a lower risk of systemic effects compared to oral formulations. However, caution is still advised, and **renal function** should be monitored if prolonged use is necessary. In cases of severe renal impairment, it is best to consult a healthcare provider before using any NSAID.

Administration

Information not available