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Overview

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This medicine contains an important and useful components, as it consists of
Polynucleotidesis available in the market in concentration

Name

Neomycin Sulphate Topical

Precaution

Before using **Neomycin Sulphate Topical**, it is critical to consult a healthcare provider to ensure that this medication is safe and appropriate for the patient. Some important precautions to consider include: - **Allergic reactions**: Neomycin is a potent **allergen**. Individuals who are allergic to **Neomycin** or other aminoglycoside antibiotics (such as **gentamicin** or **tobramycin**) should avoid using this medication. Symptoms of an allergic reaction include **rash**, **itching**, **swelling**, and more severe reactions like **difficulty breathing** or **anaphylaxis**. - **Open wounds or deep burns**: Neomycin should not be applied to **deep wounds**, **large areas of broken skin**, or **burns**. The medication can be absorbed through the skin and may cause **systemic toxicity** in these areas, especially in patients with impaired kidney function. - **Pregnancy and breastfeeding**: Neomycin should be used during **pregnancy** only if the potential benefit justifies the risk to the fetus. Since this medication is applied topically and absorption is minimal, it’s generally considered low risk, but medical advice is still crucial. Similarly, breastfeeding mothers should consult with a healthcare provider before using this drug, as it may pass into breast milk. - **Renal impairment**: Caution is advised in patients with **kidney disease** or impaired renal function, as **Neomycin** can accumulate and lead to **nephrotoxicity** (kidney damage) if absorbed in high quantities. - **Skin irritation or sensitivity**: Prolonged use or excessive application of Neomycin can lead to **skin irritation**, **itching**, and **dryness**. If these side effects occur, patients should discontinue use and consult their healthcare provider.

Indication

Neomycin Sulphate Topical is primarily used to treat **skin infections** and **irritations** caused by bacteria. Key indications include: - **Bacterial skin infections**: Neomycin is effective against **gram-positive and gram-negative bacteria**, making it useful for treating minor skin infections like **wounds**, **scrapes**, **cuts**, and **abrasions**. It helps reduce bacterial growth, preventing infection or controlling an existing one. - **Post-surgical wound care**: It may be used for **preventive care** after minor skin surgeries or **cosmetic procedures** to avoid infection and support healing. - **Dermatitis**: Neomycin can be used in combination with other treatments for **dermatitis**, particularly **inflammatory conditions** where bacterial infection is a concern. It aids in managing **redness**, **swelling**, and **irritation**. - **Minor burns**: Neomycin is sometimes used in treating **superficial burns** to prevent infection and reduce discomfort in combination with other topical treatments.

Contra indication

Certain conditions should preclude the use of **Neomycin Sulphate Topical**: - **Hypersensitivity**: Known **allergy** to Neomycin or any aminoglycoside antibiotic is a strict contraindication. Patients who have experienced an allergic reaction to **Neomycin** or related antibiotics should avoid using this product. - **Large open wounds or deep skin burns**: The medication should not be applied to **large areas of broken skin**, **deep wounds**, or **third-degree burns** due to the risk of **systemic absorption** leading to potential **toxicity** (such as nephrotoxicity or hearing loss). - **Pre-existing kidney problems**: In patients with **pre-existing kidney conditions** (e.g., chronic kidney disease or impaired renal function), the absorption of Neomycin may lead to **kidney toxicity**. Use caution in these individuals, and consult a healthcare provider. - **Viral or fungal infections**: Neomycin is not effective against **viral** or **fungal infections** and should not be used for conditions like **herpes**, **chickenpox**, or **ringworm**. Additionally, overuse can sometimes lead to the development of **secondary fungal or viral infections**. - **Eyes and mucous membranes**: This medication should **not** be used in or near the **eyes**, **mouth**, or other mucous membranes, as it may cause irritation.

Side Effect

Common side effects of **Neomycin Sulphate Topical** include: - **Skin irritation**: The most frequent side effect is localized **skin irritation**, which may present as **redness**, **burning**, **itching**, or **dryness** at the application site. If these symptoms persist or worsen, patients should consult their healthcare provider. - **Allergic reactions**: Patients with a sensitivity to Neomycin may experience **contact dermatitis**, **rash**, **swelling**, or more severe reactions such as **hives** or **anaphylaxis**. If any of these occur, discontinue use immediately and seek medical attention. - **Systemic absorption**: Although rare, excessive use or use on large areas of the body can lead to **systemic absorption** of Neomycin, potentially causing **kidney toxicity** or **hearing loss** due to **aminoglycoside toxicity**. Symptoms may include **dizziness**, **tinnitus**, or **hearing impairment**. - **Secondary infections**: Prolonged use of Neomycin on the skin can lead to the development of **secondary fungal** or **viral infections** due to the suppression of normal skin flora. Severe side effects are rare but may include: - **Kidney damage**: **Nephrotoxicity** is a potential concern if Neomycin is absorbed in significant amounts, especially in patients with existing kidney issues. - **Ototoxicity**: While unlikely with topical use, excessive or prolonged use of Neomycin can lead to **ototoxicity**, resulting in **hearing loss** or **tinnitus**.

Pregnancy Category ID

3

Mode of Action

Neomycin is an **aminoglycoside antibiotic** that works by inhibiting bacterial protein synthesis, effectively stopping bacterial growth. The mode of action is as follows: - **Inhibition of bacterial protein synthesis**: Neomycin binds to the bacterial **ribosome**, specifically the **30S subunit**, preventing the proper formation of bacterial proteins. Without proteins, the bacteria cannot grow, reproduce, or survive. - **Bactericidal effect**: By disrupting protein production, Neomycin exerts a **bactericidal** effect, meaning it **kills** the bacteria rather than simply inhibiting their growth. It is effective against a wide range of **gram-positive and gram-negative bacteria**. The antibiotic’s ability to destroy bacterial cell walls and prevent growth makes it effective in treating superficial skin infections and preventing the spread of infection in minor wounds or burns.

Interaction

Although Neomycin Sulphate is a topical treatment with limited systemic absorption, interactions can still occur: - **Other topical antibiotics**: The use of other **topical antibiotics** alongside Neomycin can increase the risk of skin irritation or **sensitization**. Combining multiple antibiotics on the skin should be done under the guidance of a healthcare provider. - **Systemic aminoglycosides**: If **Neomycin** is used alongside **systemic aminoglycoside antibiotics** (such as **gentamicin**, **tobramycin**), there could be an increased risk of **ototoxicity** (hearing damage) and **nephrotoxicity** (kidney damage). Systemic absorption of Neomycin can contribute to these effects. - **Other nephrotoxic drugs**: While Neomycin’s systemic absorption is typically low, combining it with other **nephrotoxic** drugs (e.g., **NSAIDs**, **diuretics**, **chemotherapy agents**) can increase the risk of kidney damage. It is essential to monitor renal function in these cases. - **Topical corticosteroids**: The concurrent use of **topical corticosteroids** with Neomycin can sometimes mask the underlying infection or increase the risk of secondary infections due to reduced immune response.

Pregnancy Category Note

Information not available

Adult Dose

For **Neomycin Sulphate Topical**, the typical adult dosing involves: - **Apply a thin layer** of the medication to the affected area **2-3 times daily** or as prescribed by a healthcare provider. - The **duration of use** should not exceed **7-10 days** unless directed otherwise by a doctor. Prolonged use can increase the risk of **skin irritation** and **secondary infections**.

Child Dose

For pediatric patients, the general recommendation for **Neomycin Sulphate Topical** is: - **Apply a thin layer** to the affected area **2-3 times daily**, ensuring that it is only used on **small areas** of the skin. - The **duration of use** in children should be limited to avoid potential side effects like **skin irritation** or **systemic absorption**. - Always consult a pediatric healthcare provider before use, especially for infants or very young children, to ensure appropriate treatment for their specific condition.

Renal Dose

Since **Neomycin Sulphate Topical** is applied locally with minimal systemic absorption, **no dose adjustment** is typically required for patients with renal impairment. However, in patients with **severe kidney disease**, caution should be exercised to avoid systemic absorption, especially if used on large or extensive areas of skin. Medical advice should be sought.

Administration

Information not available