CONCOR AM 10mg/10mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Bisoprolol Fumarate, Amlodipine besilateis available in the market in concentration

Name

Epoetin beta

Precaution

Before starting **Epoetin beta** therapy, patients must consult their healthcare provider to ensure that this treatment is appropriate for their condition. Several precautions need to be taken into account: - **Hypertension**: Epoetin beta can increase **blood pressure**, so blood pressure should be monitored regularly. If hypertension develops, appropriate antihypertensive measures may be needed. - **Cardiovascular Risk**: There is an increased risk of **cardiovascular events**, such as **heart attack**, **stroke**, and **heart failure**, especially in patients with **chronic kidney disease (CKD)** or those with pre-existing heart conditions. Careful monitoring is essential, and dose adjustments may be necessary. - **Thromboembolic Events**: The risk of developing **blood clots**, including **deep vein thrombosis (DVT)**, **pulmonary embolism (PE)**, and **myocardial infarction (MI)**, is increased, especially when hemoglobin levels rise too quickly. The dose should be titrated carefully to avoid these risks. - **Iron Deficiency**: Since **Epoetin beta** stimulates red blood cell production, it can exacerbate **iron deficiency**. Iron supplements should be considered to support red blood cell production and prevent iron deficiency anemia. - **Seizures**: Seizures are a rare but serious side effect of Epoetin beta, particularly in patients with a history of central nervous system (CNS) disorders. Careful monitoring is necessary for patients with such conditions. - **Allergic Reactions**: Although rare, severe **hypersensitivity reactions**, including **anaphylaxis**, may occur. Any signs of **rash**, **swelling**, **difficulty breathing**, or other signs of an allergic reaction should be immediately reported.

Indication

Epoetin beta is a **recombinant erythropoietin** that is used to treat **anemia** related to various medical conditions. It is primarily prescribed for: - **Chronic Kidney Disease (CKD)**: Epoetin beta is used to treat **anemia** in patients with CKD, particularly those undergoing **dialysis** or those who are not yet on dialysis. The drug stimulates red blood cell production to alleviate the symptoms of anemia associated with kidney disease. - **Cancer Chemotherapy-Induced Anemia**: In patients undergoing chemotherapy, Epoetin beta is used to treat **anemia** caused by chemotherapy drugs. This helps reduce the need for **blood transfusions**. - **HIV-Infected Patients on Zidovudine**: Epoetin beta is also used to treat **anemia** in **HIV-infected patients** who are receiving **zidovudine**, a drug that can cause anemia by inhibiting red blood cell production. - **Surgical Blood Loss**: Epoetin beta may be used before surgery in patients at risk of **blood loss** to increase hemoglobin levels and reduce the need for transfusions.

Contra indication

Epoetin beta should not be used in the following situations: - **Hypersensitivity**: Patients with a **known hypersensitivity** to **epoetin beta** or any of the components of the formulation should not receive the drug. - **Uncontrolled Hypertension**: Epoetin beta is contraindicated in patients with **uncontrolled hypertension**. The drug may worsen high blood pressure, so it should not be initiated in such patients until blood pressure is adequately controlled. - **Pure Red Cell Aplasia (PRCA)**: If **PRCA** (a condition where the body stops producing red blood cells) develops during treatment with Epoetin beta, the drug should be immediately discontinued. - **Autologous Blood Donation**: Epoetin beta is not recommended for patients who are donating **autologous blood** due to the increased risk of **thrombosis**.

Side Effect

Epoetin beta can cause both **common** and **serious side effects**. Some of these include: - **Common Side Effects**: - **Headache** - **Fatigue** - **Joint pain** - **Nausea** - **Cough** or **shortness of breath** - **Fever** - **Injection site reactions** (e.g., **pain**, **swelling**) - **Serious Side Effects**: - **Cardiovascular Events**: There is an increased risk of **heart attack**, **stroke**, and **heart failure**, especially in patients with underlying cardiovascular disease or cancer. - **Thrombosis**: An increased risk of **blood clots**, including **deep vein thrombosis (DVT)**, **pulmonary embolism (PE)**, and **myocardial infarction (MI)**, particularly if hemoglobin levels rise too quickly. - **Pure Red Cell Aplasia (PRCA)**: This condition is a rare but serious side effect where **red blood cell production** stops completely. It may be irreversible, and Epoetin beta must be discontinued. - **Seizures**: Rare, but **seizures** can occur, especially in patients with uncontrolled anemia or central nervous system disorders. - **Allergic Reactions**: Severe reactions, including **anaphylaxis**, are rare but may include **rash**, **swelling**, or difficulty breathing.

Pregnancy Category ID

3

Mode of Action

Epoetin beta is a **recombinant form of erythropoietin** (a naturally occurring hormone). It works by: - **Stimulating Red Blood Cell Production**: Epoetin beta binds to **erythropoietin receptors** on precursor cells in the **bone marrow**, stimulating them to differentiate and mature into **red blood cells**. - **Increasing Hemoglobin Levels**: By stimulating the production of red blood cells, it increases **hemoglobin** levels, which in turn helps to improve oxygen delivery to tissues and alleviate the symptoms of anemia. - **Restoring Erythropoiesis**: In conditions like **chronic kidney disease (CKD)** and **chemotherapy-induced anemia**, where erythropoiesis (red blood cell production) is impaired, Epoetin beta helps to restore normal red blood cell production, reducing the need for blood transfusions.

Interaction

Epoetin beta can interact with other drugs and substances, which may affect the drug’s efficacy or safety: - **Iron Supplements**: Epoetin beta increases the production of red blood cells, which can result in **increased iron demand**. Iron supplements are often required to prevent or treat **iron deficiency** during therapy. - **Antihypertensive Medications**: Since epoetin beta may increase **blood pressure**, antihypertensive medications may need to be adjusted. Blood pressure should be carefully monitored during treatment. - **Chemotherapy Drugs**: Epoetin beta can be used alongside chemotherapy to treat **anemia** induced by **cytotoxic chemotherapy agents**. However, careful monitoring is needed as some chemotherapy drugs may alter the efficacy of Epoetin beta. - **Other Erythropoiesis-Stimulating Agents**: Using multiple erythropoiesis-stimulating agents concurrently can increase the risk of **cardiovascular complications** and **thrombosis**. Careful monitoring is required if combining therapies.

Pregnancy Category Note

Information not available

Adult Dose

The dose of **Epoetin beta** varies based on the patient's condition and response. Here are the general guidelines: - **Chronic Kidney Disease (CKD)**: - The starting dose is typically **50–100 units/kg** given 3 times per week, either intravenously (IV) or subcutaneously (SC). - The dose should be adjusted based on **hemoglobin** levels, aiming for a target of **10–12 g/dL**. - **Cancer Chemotherapy-Induced Anemia**: - The usual starting dose is **150 units/kg** administered 3 times per week, via IV or SC injection. The dose may be adjusted based on response. - **HIV-Related Anemia**: - A typical starting dose is **50–100 units/kg** administered 3 times per week. - **Surgical Blood Loss**: - A higher dose, such as **300 units/kg**, is often used to stimulate erythropoiesis and minimize the need for transfusions in high-risk surgical patients.

Child Dose

Pediatric dosing for **Epoetin beta** is often similar to adult dosing but requires careful adjustments: - For **children with CKD**, the starting dose is typically **50–100 units/kg** administered 3 times per week. - **Iron supplementation** should be provided to avoid **iron deficiency** during treatment. - **Close monitoring** of **hemoglobin levels** and **side effects** is crucial for pediatric patients. As always, it is crucial for patients and caregivers to consult healthcare professionals before initiating **Epoetin beta** therapy to ensure the appropriate use, proper monitoring, and adjustments based on individual health needs.

Renal Dose

For patients with **renal impairment** (especially those on **dialysis** or with **non-dialysis-dependent CKD**), the dosing regimen must be carefully adjusted: - The initial dose is typically **50–100 units/kg** administered 3 times per week. - Doses may be increased or decreased based on **hemoglobin** levels and individual response. - **Iron supplementation** is usually required to maintain sufficient iron levels for red blood cell production.

Administration

Information not available