COMTAN 200mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Entacaponeis available in the market in concentration

Name

Entacapone

Precaution

Levodopa-induced orthostatic hypotension may be aggravated. Abrupt withdrawal. Concomitant use with a selective MAO-A and MAO-B inhibitor, or concomitant use with a selective MAO-A plus a selective MAO-B inhibitor. Biliary obstruction. Impairs ability to drive and operate machinery. Pregnancy and lactation. Children and elderly. Lactation: excretion in milk unknown; use with caution

Indication

Adjunct to levodopa treatment in Parkinson's disease.

Contra indication

History of neuroleptic malignant syndrome and nontraumatic rhabdomyolysis. Phaeochromocytoma. Hepatic impairment.

Side Effect

>10% Dyskinesia (25%),Nausea (14%),Diarrhea (10%),Hyperkinesia (10%),Urine discoloration (10%) 1-10% Hypokinesia (9%),Dizziness (8%),Abdominal pain (8%),Fatigue (6%),Constipation (6%),Back pain (4%),Vomiting (4%),Dry mouth (3%),Dyspnea (3%),Increased sweating (2%),Back pain (2%),Anxiety (2%),Somnolence (2%),Dyspepsia (2%),Flatulence (2%),Purpura (2%),Asthenia (2%),Hallucinations (1-4%),Taste perversion (1%),Agitation (1%),Gastritis (1%),Bacterial infection (1%) Frequency Not Defined Insomnia,Postural hypotension,Confusion,Dopaminergic side affects due to increased dopamine levels Rare: rhabdomyolysis, retroperitoneal fibrosis

Pregnancy Category ID

3

Mode of Action

Entacapone is a selective, reversible, peripheral inhibitor of COMT, an enzyme involved in the metabolism of dopamine and levodopa. It is used in patients with Parkinson's disease and "end-of-dose" motor fluctuations that cannot be stabilised on levodopa combinations alone.

Interaction

Drugs metabolised by COMT e.g. adrenaline, apomorphine, dobutamine, dopamine, isoprenaline, methyldopa, noradrenaline and remiterol. Iron preparations and levodopa. Avoid ethanol.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration