Active Substance: Cetrorelix (as acetate).
Overview
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This medicine contains an important and useful components, as it consists of
Cetrorelix (as acetate)is available in the market in concentration
Cetrorelix
Women with active allergic conditions or a history of allergies; childn; elderly >65 yrs Lactation: Excretion in milk unknown/contraindicated
Assisted reproductive technologies, In-vitro fertilization
Hypersensitivity. Moderate to severe renal or hepatic impairment. Women with severe allergic conditions. Pregnancy and lactation;
1-10% Ovarian hyperstimulation syndrome (4%),Nausea (1%),Hepatic enzyme elevation (1-2%),Headache (1%) <1% Erythema at injection site,Itching,Pruritus,Swelling,Redness,Hypotension,Rash,Cough
5
Cetrorelix, a synthetic decapeptide analog of naturally occurring gonadorelin, is a gonadorelin antagonist. It competitively blocks gonadorelin receptors on the anterior piyuitary gonadotroph and the subsequent transduction pathway, inducing a rapid, reversible suppression of gonadotrophin secretion.
In vitro investigations have shown that interactions are unlikely with medications that are metabolised by cytochrome P-450 or glucuronised or conjugated in some other way. However, the possibility of interactions with commonly used medicinal products can not entirely be excluded.
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