Active Substance: Diltiazem HCl.
Overview
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This medicine contains an important and useful components, as it consists of
Diltiazem HClis available in the market in concentration
Diltiazem Hydrochloride
Elderly. Hepatic or renal impairment; impaired left ventricular function; prolonged AV periods; DM; hypotension. Avoid abrupt withdrawal and long-term use. Patients with sick-sinus syndrome, preexisting AV block, bradycardia and those taking beta-blockers or digitalis are at risk of developing AV block, bradycardia, asystole or sinus arrest. Lactation: Drug enters breast milk; because of risk for serious adverse reactions in nursing infants from diltiazem, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Supraventricular tachycardia, Hypertension, Angina, Atrial fibrillation, Arrhythmias, Atrial flutter
Sick-sinus syndrome; 2nd or 3rd ° AV block; porphyria. Severe congestive cardiac failure; marked bradycardia. Pregnancy and lactation.
>10% Edema (2-15%),Headache (5-12%) 1-10% Dizziness (3-10%),AV block (2-8%),Peripheral edema (2-8%),Bradyarrhythmia (2-6%),Headache (1-5%),Hypotension (2-4%),Nausea (3%),Vomiting (2%),Vasodilation (2-3%),Extrasystoles (2%),Flushing (1-2%),Drug-induced gingival hyperplasia (<2%),Myalgia (2%),Diarrhea (1-2%),Constipation (2-4%),Bronchitis (1-4%),Sinus congestion (1-2%),Dyspnea (1-6%),Congestion (1-2%) < 1% Increased Alkaline phosphatase as well as ALT and AST,CHF,Thrombocytopenia,Toxic epidermal necrolysis,Hemolytic anemia,Photosensitivity,Extrapyramidal symptoms,Syncope
3
Diltiazem relaxes coronary vascular smooth muscles by inhibiting influx of calcium ions during depolarisation of the vascular smooth muscles and myocardium. It increases myocardial O2 delivery in patients with vasospastic angina and inhibits cardiac conduction, particularly at the SA and AV nodes.
Increased AV blocking effect w/ clonidine. May increase serum levels of statins (e.g. atorvastatin, lovastatin), carbamazepine, phenytoin. May increase bradycardic affect of amiodarone, digoxin, mefloquine. May enhance antihypertensive effect w/ other antihypertensives (e.g. aldesleukin), antipsychotic. Increased serum levels w/ cimetidine. Decreased serum levels w/ rifampicin, phenobarbital. Potentially Fatal: IV: May enhance hypotensive effect of IV ?-blockers.
Information not available