CARDEX PLUS 5/12.5mg Price

Overview

Welcome to Dwaey, specifically on CARDEX PLUS 5/12.5mg Tablets/Film-coated page.
This medicine contains an important and useful components, as it consists of Bisoprolo Fumarate/ Hydrochlorothiazide.
CARDEX PLUS 5/12.5mg is available in the market in concentration 5 mg/12.5 mg and in the form of Tablets/Film-coated.

ACINO PHARMA AG is the producer of CARDEX PLUS 5/12.5mg and it is imported from SWITZERLAND, The most popular alternatives of CARDEX PLUS 5/12.5mg are listed downward .

Mode Of Action

Bisoprolol fumarate/hydrochlorothiazide is a fixed-combination tablet that combines a Beta adrenergic receptor blocker, bisoprolol fumarate, and a thiazide diuretic, hydrochlorothiazide. Bisoprolol fumarate, a cardioselective inhibitor of beta(1)-adrenoceptor, has no significant intrinsic sympathomimetic activity or membrane stabilizing activity in its therapeutic dosage; exhibits beta(2)-adrenoceptors inhibition and negative chronotropic effect. Hydrochlorothiazide is a thiazide diuretic that inhibits Na reabsorption in distal renal tubules resulting in increased excretion of Na+ and water, also K+ and H+ ions.

Indication

• Hypertension
• Congestive heart failure
• HTN
• Angina pectoris

Precaution

Bronchospastic disease, hyperthyroidism, peripheral vascular disease, undergoing anaesthesia. Monitor blood glucose regularly. May mask symptoms of hypoglycaemia. Elderly. Gradual withdrawal is advised. Lactation: excreted in breast milk, use caution

Side Effects

• 1-10% Bisoprolol fumarate Arthralgia (3%)
• asthenia (2%)
• cough (3%)
• diarrhea (4%)
• dizziness (10%)
• dry mouth (1%)
• dyspnea (2%)
• fatigue (8%)
• headache (11%)
• hypoaesthesia (2%)
• insomnia (3%)
• nausea (2%)
• peripheral edema (4%)
• pharyngitis (2%)
• rhinitis (4%)
• sinusitis (2%)
• upper respiratory infection (5%)
• vomiting (2% ) Hydrochlorothiazide Anorexia
• Epigastric distress
• Hypokalemia
• Hypotension
• Orthostatic hypotension
• Phototoxicity Frequency Not Defined Bisoprolol fumarate Aggravate CHF
• cold extremeties
• decrease HDL
• depression
• hypotension
• increase bronchospasm
• increase triglycerides
• mask symptoms of hypoglycemia
• muscle & joint pain Hydrochlorothiazide Agranulocytosis
• anaphylaxis
• anemia
• Confusion
• erythema multiforme skin reactions including Stevens-Johnson syndrome Exfoliative dermatitis including toxic epidermal necrolysis
• Hypomagnesemia
• hyponatremia
• hypochloremia
• dizziness
• fatigue
• headache
• hypercalcemia
• hyperuricemia
• hyperglycemia
• hyperlipidemia
• hypercholesterolemia
• muscle weakness or cramps
• nausea
• purpura
• rash
• vertigo
• vomiting Potentially Fatal: AV block
• bradycardia. Rare but may occur in patients with preexisting cardiac disease. Includes severe bronchospasm
• hypoglycaemia
• hypotension
• orthostatic hypotension
• bradyarrhythmias. 'Rebound phenomenon' leading to unstable angina or MI on sudden withdrawal.

Contra indication

Low cardiac output and uncompensated cardiac failure; sinus bradycardia, 1st ° heart block, cardiogenic shock, bronchospasm; severe haemorrhage. Pregnancy.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks