Overview

Welcome to Dwaey, specifically on DEXAKERN 7.2 mg/1.8 ml Solution for injection page.
This medicine contains an important and useful components, as it consists of Dexamethasone phosphate.
DEXAKERN 7.2 mg/1.8 ml is available in the market in concentration 7.2 mg/ 1.8 ml (4 mg/ml) and in the form of Solution for injection.

KERN PHARMA, S.A is the producer of DEXAKERN 7.2 mg/1.8 ml and it is imported from SPAIN, The most popular alternatives of DEXAKERN 7.2 mg/1.8 ml are listed downward .

Mode Of Action & Indication

Dexamethasone is a synthetic glucocorticoid which decreases inflammation by inhibiting the migration of leukocytes and reversal of increased capillary permeability. It suppresses normal immune response.

Indication

• Ulcerative colitis
• Rheumatoid arthritis
• Multiple sclerosis
• Nausea and vomiting
• Multiple myeloma
• Cerebral oedema
• Shock
• Inflammatory joint diseases
• Idiopathic thrombocytopenic purpura
• Dental surgery
• Allergic anaphylactic shock
• Brain tumors
• Status asthmaticus

Precaution

This product, like many other steroid formulations, is sensitive to heat. Therefore, it should not be autoclaved when it is desirable to sterilize the exterior of the vial. Following prolonged therapy, withdrawal of corticosteroids may result in symptoms of the corticosteroid withdrawal syndrome including fever, myalgia, arthralgia, and malaise. This may occur in patients even without evidence of adrenal insufficiency. There is an enhanced effect of corticosteroids in patients with hypothyroidism and in those with cirrhosis. Corticosteroids should be used cautiously in patients with ocular herpes simplex for fear of corneal perforation. The lowest possible dose of corticosteroid should be used to control the condition under treatment, and when reduction in dosage is possible, the reduction must be gradual. Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression to frank psychotic manifestations. Also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids. Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia. Steroids should be used with caution in nonspecific ulcerative colitis, if there is a probability of impending perforation, abscess, or other pyogenic infection, also in diverticulitis, fresh intestinal anastomoses, active or latent peptic ulcer, renal insufficiency, hypertension, osteoporosis, and myasthenia gravis. When large doses are given, some authorities advise that antacids be administered between meals to help to prevent peptic ulcer. Growth and development of infants and children on prolonged corticosteroid therapy should be carefully followed. Steroids may increase or decrease motility and number of spermatozoa in some patients. Phenytoin, phenobarbital, ephedrine, and rifampin may enhance the metabolic clearance of corticosteroids resulting in decreased blood levels and lessened physiologic activity, thus requiring adjustment in corticosteroid dosage. These interactions may interfere with dexamethasone suppression tests which should be interpreted with caution during administration of these drugs. When corticosteroids are administered concomitantly with potassium-depleting diuretics, patients should be observed closely for development of hypokalemia. Intra-articular injection of a corticosteroid may produce systemic as well as local effects. Lactation: Drug excreted in breast milk; not recommended

Side Effects

• Acne
• Adrenal suppression
• Arrhythmia
• Bradycardia
• Cardiac arrest
• Cataracts
• Change in spermatogenesis
• Delayed wound healing
• Depression
• Diabetes mellitus
• Diaphoresis
• Emotional instability
• Erythema
• Euphoria
• Exophthalmos
• GI perforation
• Glaucoma
• Glucose intolerance
• Glucosuria
• Hepatomegaly
• Hypokalemic alkalosis
• Increased intracranial pressure
• Increased transaminases
• Insomnia
• Kaposi's sarcoma
• Menstrual irregularity
• Moon face
• Myopathy
• Neuritis
• Osteoporosis
• Peptic ulcer
• Perianal pruritus
• Petechia
• Perianal pruritus
• Pituitary adrenal axis suppression
• Pseudotumor cerebri (on withdrawal)
• Psychosis
• Pulmonary edema
• Rash
• Seizure
• Spermatogenesis altered (increased or decreased)
• Ulcerative esophagitis
• Urticaria
• Vertigo
• Weight gain

Contra indication

Systemic fungal infections . Hypersensitivity to any component of this product, including sulfites

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

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