BLOPRESS 16 PLUS Price

Overview

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This medicine contains an important and useful components, as it consists of
Candesartan cilexetil, Hydrochlorothiazideis available in the market in concentration

Name

Candesartan Cilexetil + Hydrochlorothiazide

Precaution

Volume or sodium depletion, preexisting renal insufficiency; aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy, renal artery stenosis, primary hyperaldosteronism. Patients with a history of angioedema, urticaria. Monitor serum potassium levels especially in elderly and renally impaired patients. Hypotension may occur during major surgery and anaesthesia due to suppression of the renin-angiotensin system. Lactation: enters breast milk/contraindicated

Indication

Hypertension, Congestive heart failure

Contra indication

Hypersensitivity.

Side Effect

1-10% Headache (3%),Dizziness (3%),Upper respiratory tract infection (4%),Back pain (3%),Flu-like syndrome (2%) Frequency Not Defined Candesartan Dizziness, headache, vertigo, back pain, upper resp tract infections, pharyngitis, rhinitis, hypotension, hyperkalaemia, increased serum creatinine. Hydrochlorothiazide Anorexia,Epigastric distress,Hypotension,Orthostatic hypotension,Photosensitivity,Anaphylaxis,Anemia,Confusion,Erythema multiforme,Stevens-Johnson syndrome,Exfoliative dermatitis including toxic epidermal necrolysis,Dizziness,Headache,Hyperuricemia,Hypokalemia and/or hypomagnesemia

Pregnancy Category ID

4

Mode of Action

Candesartan inhibits the binding of angiotensin II to AT1 receptors in many tissues (e.g. vascular smooth muscles, adrenal gland) which leads to vasoconstriction blockade and aldosterone release. Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions.

Interaction

NSAIDs may reduce antihypertensive effect and result in deterioration of renal function including possible acute renal failure. May increase serum lithium concentration. K-sparing diuretics, K supplements or salt substitutes containing K may increase risk of hyperkalaemia. Potentially Fatal: Coadministration w/ aliskiren in diabetic patients may increase risk of renal impairment, hypotension and hyperkalaemia.

Pregnancy Category Note

Pregnancy Category: C (1st trimester); D (2nd and 3rd trimesters)

Adult Dose

Child Dose

Renal Dose

Administration