BIOZAR HT 50/12.5 mg price in UAE

Overview

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This medicine contains an important and useful components, as it consists of Losartan/Hydrochlorothiazide.
BIOZAR HT 50/12.5 mg is available in the market in concentration 50/12.5 mg/ tablet and in the form of Tablet/Film coated.

BIOCON FZ-LLC is the producer of BIOZAR HT 50/12.5 mg and it is imported from UAE, The most popular alternatives of BIOZAR HT 50/12.5 mg are listed downward .

Mode Of Action

Hydrochlorothiazide increases renal excretion of sodium and chloride and reduces cardiac load. Losartan is an angiotensin II receptor (type AT1) antagonist antihypertensive which acts by blocking the actions of angiotensin II of renin-angiotensin-aldosterone system. The drug and its active metabolite selectively block the vasoconstrictor and aldosterone secreting effects of angiotensin II. The two drugs exert additive effects in hypertension.

Indication

Hypertension
Stroke risk reduction of hypertensive or LVH patients

Precaution

Existing electrolyte disturbances; hepatic cirrhosis; severe hepatic failure; oedema; elderly (>75 yr); renal impairment; hepatic impairment; diabetes, gout, hyperlipidaemia; hyperuricaemia; ECG: LVH and/or ventricular ectopics extrasystoles); volume depleted patients; patients on diuretics and salt restriction; renal artery stenosis; aortic and mitral stenosis. Monitor potassium concentration. Discontinue before performing tests for parathyroid function. Lactation: Discontinue drug or do not nurse

Side Effects

>10% Losartan Fatigue (14%)
Hypoglycemia (14%)
Chest pain (12%)
Cough
incidence higher in previous cough related to ACE therapy (3-11%) 1-10% Losartan Diarrhea (2-10%)
URI (8%)
Hypotension (7%)
Dizziness (4%)
Nausea (2%) Hydrochlorothiazide Hypotension
Anorexia
Epigastric distress
Hypokalemia
Phototoxicity
Thrombocytopenia Potentially Fatal: Hypersensitivity reactions; hemolytic anaemia; toxic epidermal necrolysis.

Contra indication

Pregnancy, lactation; intravascular volume depletion.

Pregnancy and lactation

Pregnancy category: D

There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Interaction

Reduced excretion of lithium; effect of diuretic, natriuretic & other antihypertensive w/ NSAIDs including selective COX-2 inhibitors. Do not co-administer w/ aliskiren in patients w/ diabetes & renal impairment. Losartan: Rifampin & fluconazole. Increased serum potassium w/ K-sparing diuretics (eg spironolactone, triamterene, amiloride), K supplements or salt substitutes containing K. Hydrochlorothiazide: Potentiate orthostatic hypotension w/ alcohol, barbiturates or narcotics. Antidiabetic drugs (oral agents, insulin), other antihypertensive drugs. Impaired absorption w/ cholestyramine & colestipol resins. Intensified electrolyte depletion w/ corticosteroids, ACTH, glycyrrhizin (liquorice). Possible decreased response to pressor amines (eg adrenaline); increased response to nondepolarizing skeletal muscle relaxants (eg tubocurarine). May interfere w/ parathyroid function test.