DESCOVY 200mg/25mg Price

Overview

Welcome to Dwaey, specifically on DESCOVY 200mg/25mg page.
This medicine contains an important and useful components, as it consists of
Emtricitabine / Tenofovir alafenamide fumarateis available in the market in concentration

Name

Emtricitabine + Tenofovir disoproxil

Precaution

Lactic Acidosis/Severe Hepatomegaly With Steatosis. Liver impairment. Renal impairment; avoid in CrCl <30ml/min and in patients on dialysis. Pregnancy. Not to be used with other emtricitabine, tenofovir disoproxil fumarate or other cytidine analogues (e.g. lamivudine and zalcitabine) preparations. Increased risk for severe and potentially fatal hepatic adverse reactions in patients with HIV and hepatitis B or C virus co-infection treated with antiretroviral agents. If combination drug is discontinued in patients co-infected with HIV and HBV, monitor hepatic function for several months for acute exacerbation of hepatitis. Discontinue therapy if there is a rapid rise in aminotransferase concentrations, progressive hepatomegaly or steatosis, metabolic or lactic acidosis of unknown cause. Test for presence of chronic HBV before initiating therapy. Check CrCl before initiation of therapy and monitor renal function (CrCl and serum phosphate) every 4 wkly during the 1st year and then every 3 mthly (more frequently in patients at risk for renal impairment). Bone monitoring needed for patient with history of pathologic bone fracture or at risk of osteopenia. Monitor child exposed in utero to combination drug for possible mitochondrial dysfunction. Lactation: excretion in milk unknown/not recommended

Indication

HIV-1 infection, Pre-exposure Prophylaxis HIV-1 infection

Contra indication

Lactation. Not to be used for treatment of chronic hepatitis B virus (HBV) infection.

Side Effect

>10% Diarrhea,Nausea,Fatigue,Headache,Dizziness,Depression,Insomnia,Abnormal dreams,Rash 1-10% Note: includes adverse effects grade 2-4 Diarrhea (9%),Nausea (9%),Fatigue (9%),Depression (9%),Sinusitis (8%),URI infections (8%),Dizziness (8%),Rash event (7%),Headache (6%),Nasopharyngitis (5%),Insomnia (5%),Vomiting (2%) Potentially Fatal: Lactic acidosis and severe hepatomegaly with steatosis.

Pregnancy Category ID

2

Mode of Action

Tenofovir disoproxil fumarate, a diester prodrug of tenofovir, is rapidly converted to tenofovir, an acyclic nucleoside phosphonate (nucleotide) analogue of adenosine 5'-monophosphate while emtricitabine is a synthetic nucleoside analogue of cytidine. Both emtricitabine and tenofovir inhibit HIV-1 reverse transcriptase, resulting in DNA chain termination.

Interaction

Decreased atazanavir concentration with tenofovir unless also co-administered with ritonavir. Increased serum concentration of both tenofovir and emtricitabine or co-administered drug if taken with drugs that are eliminated by active tubular secretion. Potentially Fatal: Increased risk of renal impairment with recent or concurrent use of nephrotoxic agents (e.g. aminoglycosides, amphotericin B, foscarnet, ganciclovir, pentamidine, vancomycin, cidofovir or interleukin-2); monitor renal function wkly if unavoidable. Increased didanosine levels and thereby increasing risk of pancreatitis and peripheral neuropathy, with a high treatment failure rate with concurrent use; avoid concurrent use. Do not use emtricitabine with lamivudine due to similar resistance profile. Increased risk of lactic acidosis with ?-interferon.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration