DESCOVY 200mg/25mg price in UAE

Overview

Welcome to Dwaey, specifically on DESCOVY 200mg/25mg Tablets/Film-coated page.
This medicine contains an important and useful components, as it consists of Emtricitabine / Tenofovir alafenamide fumarate.
DESCOVY 200mg/25mg is available in the market in concentration 200mg, 25mg/Tablet and in the form of Tablets/Film-coated.

GILEAD SCIENCES INTERNATIONAL LTD. is the producer of DESCOVY 200mg/25mg and it is imported from UK, The most popular alternatives of DESCOVY 200mg/25mg are listed downward .

Mode Of Action

Tenofovir disoproxil fumarate, a diester prodrug of tenofovir, is rapidly converted to tenofovir, an acyclic nucleoside phosphonate (nucleotide) analogue of adenosine 5'-monophosphate while emtricitabine is a synthetic nucleoside analogue of cytidine. Both emtricitabine and tenofovir inhibit HIV-1 reverse transcriptase, resulting in DNA chain termination.

Indication

HIV-1 infection
Pre-exposure Prophylaxis HIV-1 infection

Precaution

Lactic Acidosis/Severe Hepatomegaly With Steatosis. Liver impairment. Renal impairment; avoid in CrCl <30ml/min and in patients on dialysis. Pregnancy. Not to be used with other emtricitabine, tenofovir disoproxil fumarate or other cytidine analogues (e.g. lamivudine and zalcitabine) preparations. Increased risk for severe and potentially fatal hepatic adverse reactions in patients with HIV and hepatitis B or C virus co-infection treated with antiretroviral agents. If combination drug is discontinued in patients co-infected with HIV and HBV, monitor hepatic function for several months for acute exacerbation of hepatitis. Discontinue therapy if there is a rapid rise in aminotransferase concentrations, progressive hepatomegaly or steatosis, metabolic or lactic acidosis of unknown cause. Test for presence of chronic HBV before initiating therapy. Check CrCl before initiation of therapy and monitor renal function (CrCl and serum phosphate) every 4 wkly during the 1st year and then every 3 mthly (more frequently in patients at risk for renal impairment). Bone monitoring needed for patient with history of pathologic bone fracture or at risk of osteopenia. Monitor child exposed in utero to combination drug for possible mitochondrial dysfunction. Lactation: excretion in milk unknown/not recommended

Side Effects

>10% Diarrhea
Nausea
Fatigue
Headache
Dizziness
Depression
Insomnia
Abnormal dreams
Rash 1-10% Note: includes adverse effects grade 2-4 Diarrhea (9%)
Nausea (9%)
Fatigue (9%)
Depression (9%)
Sinusitis (8%)
URI infections (8%)
Dizziness (8%)
Rash event (7%)
Headache (6%)
Nasopharyngitis (5%)
Insomnia (5%)
Vomiting (2%) Potentially Fatal: Lactic acidosis and severe hepatomegaly with steatosis.

Contra indication

Lactation. Not to be used for treatment of chronic hepatitis B virus (HBV) infection.

Pregnancy and lactation

Pregnancy category: B

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Interaction

Decreased atazanavir concentration with tenofovir unless also co-administered with ritonavir. Increased serum concentration of both tenofovir and emtricitabine or co-administered drug if taken with drugs that are eliminated by active tubular secretion. Potentially Fatal: Increased risk of renal impairment with recent or concurrent use of nephrotoxic agents (e.g. aminoglycosides, amphotericin B, foscarnet, ganciclovir, pentamidine, vancomycin, cidofovir or interleukin-2); monitor renal function wkly if unavoidable. Increased didanosine levels and thereby increasing risk of pancreatitis and peripheral neuropathy, with a high treatment failure rate with concurrent use; avoid concurrent use. Do not use emtricitabine with lamivudine due to similar resistance profile. Increased risk of lactic acidosis with ?-interferon.