Active Substance: Oestrogens (conjugated).
Overview
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This medicine contains an important and useful components, as it consists of
Oestrogens (conjugated)is available in the market in concentration
Acyclovir 5% Topical
Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration. Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application.
Herpes virus infections of skin
Hypersensitivity.
>10% Burning/stinging (30%) 1-10% Pruritus (4%) <1% Dry lips (<1%),Rash (0.3%) Frequency Not Defined Angioedema,Vulvitis
2
Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.
Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).
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