AVIGAN 200 mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Favipiraviris available in the market in concentration

Name

Rabies Immunoglobulin USP

Precaution

Before receiving **Rabies Immunoglobulin USP** (Human), it is essential to consult with a healthcare provider to ensure safe and appropriate use. The following precautions should be considered: - **Allergic Reactions**: Rabies Immunoglobulin can cause **allergic reactions**, including severe reactions like **anaphylaxis**. Patients with a history of **allergies** to immunoglobulins or components of the product should inform their healthcare provider. - **Immunodeficiencies**: Individuals with **immune system disorders** or **hypogammaglobulinemia** may have a higher risk of side effects and should use Rabies Immunoglobulin under close medical supervision. It is important to assess immune function before use. - **Pregnancy and Breastfeeding**: Although **Rabies Immunoglobulin** is generally considered safe during pregnancy and breastfeeding, it should only be used when absolutely necessary. Discuss with a healthcare provider if pregnant or breastfeeding, as the risks and benefits need careful evaluation. - **Renal Function**: Rabies Immunoglobulin contains a **high concentration of protein**, and individuals with **pre-existing kidney conditions** (e.g., **renal insufficiency** or **renal failure**) may need dosage adjustments or more frequent monitoring. - **Hematologic Concerns**: Patients with **thrombocytopenia** or other clotting disorders should be monitored carefully, as the product may influence platelet aggregation or coagulation.

Indication

Rabies Immunoglobulin USP is used primarily for **post-exposure prophylaxis (PEP)** in individuals who have been potentially exposed to the rabies virus. The key indications include: - **Rabies Post-Exposure Prophylaxis**: Rabies Immunoglobulin is given in combination with the rabies vaccine after a potential exposure to rabies (e.g., bite, scratch, or saliva contact with a rabid animal). It is used to neutralize the virus at the site of exposure and prevent the onset of rabies infection. - **Rabies Exposure**: It is indicated for individuals who have been exposed to rabies through **animal bites or scratches**, especially when the exposure is from an animal that may be infected with the rabies virus. - **High-Risk Groups**: People who are at high risk of being exposed to rabies, such as **veterinarians**, **animal handlers**, or those living in areas with endemic rabies, may receive Rabies Immunoglobulin in certain situations.

Contra indication

Rabies Immunoglobulin is contraindicated in certain situations, and these should be discussed with a healthcare provider: - **Hypersensitivity to Immunoglobulin**: The product should not be administered to individuals who are known to be allergic to **immunoglobulins**, **IgG**, or any of the components in the formulation. - **History of Severe Allergic Reactions**: People with a **history of anaphylaxis** or other **severe hypersensitivity reactions** to immunoglobulins should not receive this treatment unless absolutely necessary, under medical supervision. - **Active Rabies Infection**: Rabies Immunoglobulin is not intended to treat an active rabies infection. It is used only for **post-exposure prevention** in individuals who have not yet developed symptoms of rabies. - **Certain Blood Disorders**: If a patient has a **history of hemolysis** (destruction of red blood cells) or other **hemolytic disorders**, Rabies Immunoglobulin should be used cautiously, as it may trigger or worsen these conditions.

Side Effect

While Rabies Immunoglobulin is generally well tolerated, some side effects may occur. Common and severe side effects include: - **Local Reactions**: Pain, **redness**, and **swelling** at the injection site are common side effects. - **Allergic Reactions**: Serious allergic reactions, including **anaphylaxis**, may occur in some individuals. Symptoms may include **difficulty breathing**, **rash**, **hives**, and **swelling** of the throat or lips. These reactions require immediate medical attention. - **Fever**: Some individuals may develop **mild fever** after receiving the injection. - **Chills and Malaise**: Fatigue, **chills**, or **general discomfort** may occur, especially in individuals with sensitive immune systems. - **Hemolysis**: A rare but serious complication is **hemolysis**, or the destruction of red blood cells, which can lead to **anemia** and **kidney problems**. - **Headache**: A headache is a common side effect that usually resolves over time. - **Nausea and Vomiting**: Some people may experience **nausea**, which may be accompanied by vomiting. - **Serum Sickness**: A delayed hypersensitivity reaction, known as **serum sickness**, can occur with symptoms like **joint pain**, **fever**, **rash**, and **swelling**.

Pregnancy Category ID

3

Mode of Action

Rabies Immunoglobulin USP contains human-derived **immunoglobulin** (antibodies) that specifically target the rabies virus. Its mechanism of action is as follows: - **Neutralization of Rabies Virus**: Rabies Immunoglobulin provides immediate passive immunity by neutralizing the rabies virus at the site of exposure. The antibodies in the immunoglobulin bind to the virus, preventing its ability to infect healthy cells. - **Supports Active Immunization**: Rabies Immunoglobulin works in synergy with the **rabies vaccine**, which induces the body's own immune system to produce active antibodies. The immunoglobulin offers immediate protection while the vaccine stimulates the body’s long-term immune response. - **Prevention of Viral Replication**: The immunoglobulins block viral entry into cells, preventing further replication of the rabies virus in the body, reducing the risk of developing **rabies encephalitis** (inflammation of the brain).

Interaction

Several medications and substances may interact with **Rabies Immunoglobulin**, potentially affecting its effectiveness or safety: - **Immunosuppressive Drugs**: Medications that suppress the immune system, such as **corticosteroids** or **chemotherapy**, may affect the body's response to Rabies Immunoglobulin. It is crucial to inform the healthcare provider about any ongoing immunosuppressive therapy. - **Vaccines**: Rabies Immunoglobulin should be given in combination with the **rabies vaccine**, but it is not to be administered at the same injection site as the vaccine. Adequate spacing is needed between vaccine administration and immunoglobulin. - **Live Vaccines**: Since Rabies Immunoglobulin contains immunoglobulin derived from human blood, **live vaccines** (such as **measles**, **mumps**, and **rubella** vaccines) should not be administered within a period of several months (usually 3 months) after receiving Rabies Immunoglobulin, as it may impair the body's immune response to the live vaccine. - **Blood Products**: Receiving other blood products or immune globulin preparations may alter the body’s immune response to the rabies vaccine, requiring special consideration when administering Rabies Immunoglobulin.

Pregnancy Category Note

Information not available

Adult Dose

For **adults**, the recommended dose of **Rabies Immunoglobulin USP** is generally as follows: - **Post-Exposure Prophylaxis (PEP)**: The standard dose is **20 IU/kg** of body weight, administered as soon as possible after exposure. It should be given via **intramuscular (IM)** or **intradermal (ID)** injection, with the total dose divided over multiple sites if necessary. - **Dosage Timing**: Rabies Immunoglobulin should be administered **immediately** after suspected exposure to rabies, alongside the **rabies vaccine**. The vaccine schedule typically involves several doses over a 14-day period.

Child Dose

For **children**, the dose of Rabies Immunoglobulin is typically the same as for adults, based on **20 IU/kg** of body weight. The dose is adjusted according to the child’s weight, and the immunoglobulin should be administered alongside the rabies vaccine. The method of administration (IM or ID) may vary depending on the child’s age and size. **Important Reminder**: Consult a healthcare provider before initiating treatment with **Rabies Immunoglobulin** to ensure proper dosage, safety, and effectiveness based on individual circumstances. It is crucial to follow the full course of treatment with the rabies vaccine to ensure optimal protection from the virus.

Renal Dose

For individuals with **renal impairment**, dose adjustments for Rabies Immunoglobulin may not be necessary. However, caution should be exercised, especially in those with **severe renal dysfunction**, as the product may have a **high protein content**. Close monitoring is recommended for such patients, as impaired renal function could increase the risk of **protein buildup** or related complications.

Administration

Information not available