Active Substance: Co-amoxiclav.
Overview
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This medicine contains an important and useful components, as it consists of
Co-amoxiclavis available in the market in concentration
Amoxicillin + Clavulanic Acid (Clavulanate)
History of allergy especially to cephalosporins, infectious mononucleosis, severe renal impairment. Lactation: Drug excreted in breast milk; use caution
Bacterial infections, Acute otitis media, Acute bacterial sinusitis, Endocarditis, Dental abscess, Community-acquired pneumonia, Acute uncomplicated UTI, Uncomplicated gonorrhea, Severe or recurrent resp tract infections
Penicillin allergy.
>10% Diarrhea (3-34%; varies upon dose and regimen) 1-10% Diaper rash (3.5%),Mycosis (3.3%),Nausea (2-3%),Rash (1-3%),Vomiting (1-2.2%),Loose stool (1.6%),Candidiasis (1.4%),Vaginitis (1%) <1% Hypersensitivity reactions,Anaphylaxis,Anemia,Thrombocytopenia,Leukopenia,Agranulocytosis,Hepatoxicity,AST/ALT elevation,Pseudomembranous colitis,Serum sickness,Abdominal discomfort,Cholestatic jaundice,Flatulence Potentially Fatal: Anaphylactic reaction with CV collapse esp with parenteral use.
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Clavulanic acid has a high affinity for and binds to certain ?-lactamases that generally inactivate amoxicillin by hydrolyzing its ?-lactam ring. Combining clavulanate potassium with amoxicillin extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other penicillins and cephalosporins.
Allopurinol may reduce renal tubular secretion of amoxicillin thus increasing the serum levels of amoxicillin. Concurrent use may reduce the efficacy of oral contraceptives.
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