ARLEVERT 20mg /40mg Price in UAE

Overview

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This medicine contains an important and useful components, as it consists of
Cinnarizine/Dimenhydrinateis available in the market in concentration

Name

Cinnarizine + Dimenhydrinate

Precaution

Hypotension; pregnancy; lactation; elderly. May impair ability to drive or operate machineries.

Indication

Nausea and vomiting, motion sickness, vertigo, meniere's disease, peripheral vascular diseases, cerebrovascular disorders, vestibular disorders

Contra indication

Proven hypersensitivity to the drug. Parkinson's disease. Childn and neonates.

Side Effect

Extrapyramidal symptoms sometimes associated with severe depression. Drowsiness, headache, GI upsets, unsteadiness, headache; rarely skin and hypersensitivity reactions, dry mouth, blurred vision, urinary difficulty or retention, constipation and increased gastric reflux, fatigue. Hypolipidaemic effect.

Pregnancy Category ID

Mode of Action

Cinnarizine has calcium-channel blocking activity selective for arterial smooth muscle. It also has some antihistamine activity. Cinnarizine acts as a labyrinthine sedative. It also improves microcirculation by reducing ischaemia-induced blood viscosity. Dimenhydrinate is an antihistamine which also has antimuscarinic and central sedative action. It also exerts a depressant action on hyperstimulated labyrinthine function.

Interaction

Cinnarizine: CNS depressant effect enhanced with alcohol. Action potentiated by domperidone. Dimenhydrinate: Physically incompatible with aminophylline, hydrocortisone, phenothiazines and some barbiturates in solution. Potentially Fatal: Potentiates the sedative effects of CNS depressants including alcohol, barbiturates, opioid analgesics, sedatives and neuroleptics. MAOIs, atropine, TCAs enhance antimuscarinic effect. Masks ototoxicity produced by aminoglycoside antibiotics.