Active Substance: Nevirapine (as hemihydrate).
Overview
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This medicine contains an important and useful components, as it consists of
Nevirapine (as hemihydrate)is available in the market in concentration
Nevirapine
Pregnancy. Interrupt treatment if severe hepatotoxicity or life-threatening skin reactions develop. Renal or hepatic insufficiency. Monitor liver function periodically.
HIV infection
Hypersensitivity. Lactation. Severe hepatic impairment.
Skin rash, nausea, vomiting, headache, abnormal LFT, fatigue, diarrhoea, abdominal pain. Potentially Fatal: Severe and life-threatening hepatotoxic and skin reactions
2
Nevirapine is a non-nucleoside reverse transcriptase inhibitor that acts against HIV-1. It binds directly to reverse transcriptase and thereby blocks the RNA-dependent and DNA-dependent DNA polymerase activities by disrupting the enzyme's catalytic site.
Mutually increased levels effects when used with drugs extensively metabolised by CYP3A. Reduced levels/effects of methadone.
Information not available