VERCANZA 450mg price in UAE

Overview

Welcome to Dwaey, specifically on VERCANZA 450mg Tablets/Film-coated page.
This medicine contains an important and useful components, as it consists of Valganciclovir.
VERCANZA 450mg is available in the market in concentration 450mg/tablet and in the form of Tablets/Film-coated.

SPIMACO (AL QASSIM PHARMACEUTICAL PLANT) is the producer of VERCANZA 450mg and it is imported from SAUDI ARABIA, The most popular alternatives of VERCANZA 450mg are listed downward .

Mode Of Action

Valganciclovir is an L-valyl ester (prodrug) of ganciclovir that exists as a mixture of 2 diastereomers. After oral admin, both diastereomers are rapidly converted to ganciclovir by intestinal and hepatic esterases. Ganciclovir is a synthetic analogue of 2'-deoxyguanosine, which inhibits replication of human cytomegalovirus (CMV) in cell culture and in vivo.

Indication

Cytomegalovirus infections

Precaution

Patient w/ pre-existing haematological cytopenia, history of drug-related haematological cytopenia. Renal impairment. Pregnancy. Lactation: not known if distributed in breast milk; do not nurse

Side Effects

>10% Abdominal pain (15%)
Anemia (8-26%)
Diarrhea (16-41%)
Fever (31%)
Granulocytopenia (11-27%)
Headache (9-22%)
Insomnia (16%)
Nausea (8-30%)
Retinal detachment (15%)
Vomiting (21%) 1-10% Peripheral neuropathy (9%)
Paresthesia (8%)
Seizures (<5%)
Psychosis
hallucinations (<5%)
Confusion (<5%)
Agitation (<5%)
Thrombocytopenia (8%)
Pancytopenia (<5%)
Bone marrow depression (<5%)
Aplastic anemia (<5%)
Bleeding
potentially life-threatening due to thrombocytopenia (<5%)
Decr renal function (<5%)
Local & systemic infections
incl sepsis (<5%)
Allergic reaction (<5%)

Contra indication

Hypersensitivity. Haemodialysis patients (CrCl <10 mL/min). Lactation. Should not be administered if the absolute neutrophil count is <500 cells/?L, platelet count is <25,000/?L, or Hb is <8 g/dL.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Interaction

Convulsions may occur if taken concomitantly w/ imipenem-cilastatin. Increased exposure w/ probenecid. Increased risk of neutropenia and anaemia w/ zidovudine. May increase plasma concentrations of didanosine. Increased risk of neutropenia and leucopenia w/ mycophenolate mofetil. Increased risk of peripheral neuropathy w/ zalcitabine. Enhanced toxicity w/ other drugs that inhibit replication of rapidly dividing cells (e.g. dapsone, vincristine, vinblastine, amphotericin B, trimethoprim/sulfa combinations, nucleoside analogues, hydroxyurea), cidofovir, foscamet.