Active Substance: Telmisartan - Amlodipine Besilate Ð .
Overview
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This medicine contains an important and useful components, as it consists of
Telmisartan -
Amlodipine Besilate Ð
is available in the market in concentration
Amlodipine + Telmisartan
May increase frequency and/or severity of angina during treatment initiation or dosage increments. Heart failure or hepatic impairment. Lactation: Discontinue drug or do not breast feed
Hypertension
Liver insufficiency. Pregnancy.
>10% Peripheral edema (1-11%) 1-10% Dizziness (3%),Orthostatic hypotension (6%),Syncope (2%),Back pain (2%)
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Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the slow channels or select voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial oxygen delivery in patients w/ vasospastic angina. Telmisartan is a nonpeptide AT1 angiotensin II receptor antagonist. It exerts antihypertensive activity by preventing angiotensin II from binding to AT1 receptors thus inhibiting the vasoconstricting and aldosterone-secreting effects of angiotensin II.
Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the slow channels or select voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial oxygen delivery in patients w/ vasospastic angina.
Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters)