TECFIDERA 240 Price

Overview

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This medicine contains an important and useful components, as it consists of
Dimethyl fumarateis available in the market in concentration

Name

Lodoxamide

Precaution

Before using **Lodoxamide**, it is crucial for individuals to consult with a healthcare provider to ensure it is suitable for their condition. Several precautions should be considered: - **Allergic Reactions**: Individuals with a known allergy to **lodoxamide** or any of the ingredients in the formulation should avoid its use. Patients should notify their healthcare provider if they have a history of severe allergic reactions to medications or other substances. - **Eye Conditions**: Lodoxamide is primarily used for **allergic conjunctivitis**. Therefore, it should be used cautiously in patients with underlying eye conditions that could potentially be aggravated by the medication, such as **corneal epithelial defects** or **dry eye disease**. - **Pregnancy and Breastfeeding**: The safety of **lodoxamide** during pregnancy and breastfeeding has not been thoroughly established. It should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Pregnant women or those breastfeeding should consult with their doctor before using this medication. - **Contact Lenses**: Individuals who wear **contact lenses** should remove them before applying lodoxamide drops and should wait at least **15 minutes** after applying the medication before reinserting their lenses.

Indication

Lodoxamide is a **mast cell stabilizer** that is used to treat **allergic conjunctivitis** and related symptoms: - **Allergic Conjunctivitis**: It is primarily used to prevent or treat eye inflammation due to allergies. This condition is characterized by symptoms such as **itching**, **redness**, **swelling**, and **watering** of the eyes caused by allergens like pollen, dust, and pet dander. - **Itchy Eyes**: Lodoxamide helps to reduce the itching sensation and other inflammatory responses caused by exposure to allergens. - **Allergic Reactions**: It can also be used to treat eye irritation from other allergic reactions.

Contra indication

Lodoxamide should not be used in certain situations, and the following conditions are considered contraindications: - **Hypersensitivity**: Individuals with a known hypersensitivity or allergic reaction to **lodoxamide** or any of its components should not use this medication. If an allergic reaction such as swelling, rash, or difficulty breathing occurs, discontinue use and seek medical attention immediately. - **Severe Eye Conditions**: The use of lodoxamide is contraindicated in patients with severe eye conditions, such as **acute eye infections** or significant damage to the **cornea** (e.g., corneal ulcers). In these cases, a healthcare provider will evaluate the condition and suggest alternative treatment options.

Side Effect

Most patients tolerate **lodoxamide** without major issues, but like any medication, side effects can occur. Common side effects may include: - **Eye Irritation**: This is the most common side effect and includes symptoms such as mild **stinging** or **burning** when the drops are applied. - **Blurred Vision**: A transient blurring of vision may occur shortly after using the eye drops, but it typically resolves quickly. - **Dry Eyes**: Some individuals may experience **dryness** or **discomfort** in the eyes after using lodoxamide. - **Headache**: A mild headache may be experienced by some individuals, though it is not a common side effect. - **Rare Side Effects**: In rare cases, more serious allergic reactions, including **swelling of the eyes**, **rash**, or **difficulty breathing**, may occur. If any of these symptoms appear, the patient should discontinue the medication and seek medical attention immediately.

Pregnancy Category ID

2

Mode of Action

Lodoxamide works by **stabilizing mast cells**, which are responsible for releasing **histamines** and other inflammatory substances during allergic reactions. Specifically, it prevents the release of **histamines** and **leukotrienes**, which are chemicals that contribute to allergic symptoms like eye redness, itching, and swelling. By stabilizing the mast cells, lodoxamide helps to **reduce the severity** of allergic responses and inflammation in the eyes. - **Histamine Blockage**: Histamines, when released during allergic reactions, cause the symptoms of itching and irritation in the eyes. By stabilizing mast cells, lodoxamide **reduces histamine release**, providing relief from these symptoms. - **Anti-inflammatory Action**: In addition to blocking histamine release, it also reduces the overall **inflammatory response** within the eye, further preventing swelling and redness associated with allergic conjunctivitis.

Interaction

Lodoxamide is generally well-tolerated, but it may interact with other medications or substances: - **Other Eye Medications**: When used alongside other eye medications, lodoxamide may interact with other treatments that affect eye inflammation, such as **steroid eye drops** or other **anti-allergy treatments**. It is essential to space out different eye medications by at least **5 minutes** to minimize the risk of interactions. - **Systemic Medications**: Although lodoxamide is applied topically to the eyes, systemic interactions are rare. However, patients using multiple **ocular treatments** should inform their healthcare provider to avoid unintended overlapping effects. - **Contact Lenses**: While not an interaction per se, lodoxamide should not be used with contact lenses in place. After applying the drops, patients should wait **at least 15 minutes** before reinserting contact lenses to avoid any discomfort or potential damage to the lenses.

Pregnancy Category Note

Information not available

Adult Dose

The usual dose of **lodoxamide** for adults is as follows: - **Initial Dosage**: The recommended dosage for **adult** patients is **one drop** in each affected eye, usually administered **four times a day** (every 4 to 6 hours). - **Maintenance Dosage**: Depending on the severity of symptoms and the doctor's recommendation, the dosage may be adjusted to maintain symptom control. - **Duration of Use**: The duration of use depends on the patient's response and the persistence of symptoms. For chronic allergy sufferers, this treatment may be continued for **several weeks** during allergy seasons.

Child Dose

For **pediatric** patients, the dosing recommendations are as follows: - **Children aged 2 years and older**: The typical dose is **one drop** in each affected eye, administered **four times daily** (every 4 to 6 hours), similar to the adult dosage. - **Children under 2 years**: The safety and efficacy of lodoxamide in children younger than **2 years old** have not been established. Parents should consult with a healthcare provider for guidance if considering this medication for younger children. In general, it is important for caregivers to follow the prescribed dosage and consult with the healthcare provider if any side effects or unusual reactions are observed in pediatric patients.

Renal Dose

There are no known significant renal dose adjustments required for patients with **renal impairment** when using **lodoxamide**. The medication is used topically, and its systemic absorption is minimal. However, patients with severe kidney problems should always consult with their healthcare provider before starting any new medication, including lodoxamide, for a full evaluation of their overall treatment plan.

Administration

Information not available