Active Substance: Exemestane.
Overview
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This medicine contains an important and useful components, as it consists of
Exemestaneis available in the market in concentration
Exemestane
Hepatic and renal impairment. Monitor bone mineral density at regular intervals especially in patients at risk of osteoporosis. Lactation: Excretion in milk unknown; because of potential for serious adverse reactions in breast-fed infants, advise women not to breastfeed during treatment and for 1 month after final dose
Breast cancer in postmenopausal women
Hypersensitivity. Premenopausal women. Pregnancy and lactation.
>10% Fatigue (22%),Nausea (18%),Hot flashes (13%),Depression (13%),Pain (13%),Insomnia (11%) 1-10% Anxiety (10%),Dyspnea (10%),Dizziness (8%),Headache (8%),Edema (7%),Vomiting (7%),Flu-like syndrome (6%),Abdominal pain (6%),Anorexia (6%),Cough (6%),Hypertension (5%),Constipation (5%),Diarrhea (4%) <1% Cardiac failure,Uterine polyps,Endometrial hyperplasia,Gastric ulcer Frequency not defined Hepatitis,Visual disturbances
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Exemestane is an irreversible selective aromatase inhibitor which acts as a false substrate for the aromatase enzyme, forming an intermediate that binds irreversibly to the active site causing its inactivation. It also lowers circulating oestrogens in estrogen-dependent breast carcinoma.
May result in reduced plasma levels of exemestane when used with CYP3A4 enzyme inducers. Oestrogen-containing drugs; St. John's wort, black cohosh, dong quai.
Information not available