SYNAGIS 100mg/ml (50mg/0.5 ml) Price

Overview

Welcome to Dwaey, specifically on SYNAGIS 100mg/ml (50mg/0.5 ml) page.
This medicine contains an important and useful components, as it consists of
Palivizumabis available in the market in concentration

Name

Primrose Oil

Precaution

Before using **Primrose Oil**, it is essential to consult a healthcare provider, especially if you have certain health conditions or are taking other medications. Here are key precautions to consider: - **Allergies**: People who are allergic to plants in the *Onagraceae* family (such as evening primrose) should avoid using primrose oil due to the potential for allergic reactions. - **Pregnancy and Breastfeeding**: Primrose oil is generally considered safe for use during pregnancy and breastfeeding, but it should still be used under medical supervision. There is limited research on its safety, so it is important to consult a healthcare provider before using it. - **Seizure Disorders**: Primrose oil may lower the seizure threshold, which could be a concern for individuals with a history of seizures or those taking medications for epilepsy. It is crucial to consult a doctor before using it if you have such conditions. - **Blood Clotting Disorders**: Since primrose oil has mild blood-thinning properties, it should be used cautiously in individuals with bleeding disorders or those on blood-thinning medications such as **warfarin** or **aspirin**. It can increase the risk of bleeding. - **Surgery**: Discontinue primrose oil at least 2 weeks prior to any surgery, as its blood-thinning properties may increase the risk of bleeding during or after the procedure. - **Diabetes**: If you have diabetes, primrose oil may interact with insulin or other diabetes medications, potentially altering blood sugar levels. Regular monitoring is recommended.

Indication

**Primrose Oil** is derived from the seeds of the evening primrose plant (*Oenothera biennis*), and it is primarily used for its high content of **gamma-linolenic acid (GLA)**, an omega-6 fatty acid. It is typically prescribed or used for: - **Skin Conditions**: Primrose oil is most commonly used for skin health, especially in conditions like **eczema** and **psoriasis**, as it may help reduce inflammation and improve skin hydration and elasticity. - **Premenstrual Syndrome (PMS)**: The oil is also used to alleviate symptoms of PMS, including irritability, bloating, and breast tenderness, due to its anti-inflammatory effects. - **Menopausal Symptoms**: Some women use primrose oil to manage menopausal symptoms, such as hot flashes and mood swings, as it is believed to support hormonal balance. - **Rheumatoid Arthritis**: Primrose oil’s anti-inflammatory properties may provide relief for individuals suffering from **rheumatoid arthritis**, potentially reducing joint pain and stiffness. - **Heart Health**: Although there is less evidence for this, primrose oil is sometimes used to support heart health by reducing cholesterol levels and supporting vascular health.

Contra indication

While **Primrose Oil** has many therapeutic benefits, it is contraindicated in certain conditions: - **Pregnancy (High doses)**: High doses of primrose oil should be avoided during pregnancy, as there are concerns that it may trigger labor or cause complications. - **Epilepsy**: Those with a history of seizures should avoid primrose oil or use it only under a doctor’s supervision due to its potential to lower the seizure threshold. - **Bleeding Disorders**: Individuals with bleeding disorders (e.g., hemophilia) or those on anticoagulant therapy (e.g., warfarin, aspirin) should avoid using primrose oil, as it may increase the risk of bleeding. - **Liver Disease**: Although rare, if you have liver disease or dysfunction, it is important to consult a doctor before using primrose oil, as there could be potential liver interactions. - **Pre-surgery**: Because primrose oil can affect blood clotting, it should be discontinued 2 weeks prior to any surgery.

Side Effect

Common and serious side effects of **Primrose Oil** include: - **Common side effects**: - **Gastrointestinal discomfort**: Some individuals may experience mild side effects such as stomach upset, diarrhea, or nausea. - **Headaches**: Primrose oil has been reported to cause headaches or migraines in some individuals. - **Skin reactions**: Occasionally, individuals may experience mild skin rashes or itching, especially when using topically. - **Dizziness**: Dizziness or lightheadedness may occur in some users, especially when taking the oil in high doses. - **Severe side effects**: - **Allergic reactions**: Though rare, severe allergic reactions can occur, characterized by swelling of the face, lips, tongue, or throat, leading to difficulty breathing. This requires immediate medical attention. - **Increased bleeding risk**: Because primrose oil may have blood-thinning effects, there is a risk of excessive bleeding, particularly for individuals on anticoagulant therapy or those undergoing surgery. - **Seizures**: Although rare, high doses of primrose oil may increase the risk of seizures in individuals with a history of epilepsy or seizure disorders. It is crucial to report any unusual or severe side effects to a healthcare provider as soon as possible.

Pregnancy Category ID

5

Mode of Action

The therapeutic effects of **Primrose Oil** are primarily attributed to its high content of **gamma-linolenic acid (GLA)**, a type of omega-6 fatty acid that is involved in the production of **prostaglandins**. Prostaglandins are hormone-like substances that regulate various physiological functions, including inflammation, blood clotting, and hormonal balance. The mechanism of action involves: - **Anti-inflammatory effects**: GLA in primrose oil is converted to **dihomo-gamma-linolenic acid (DGLA)**, which then produces anti-inflammatory prostaglandins. This helps reduce inflammation in conditions like **eczema**, **rheumatoid arthritis**, and other inflammatory disorders. - **Hormonal balance**: Primrose oil may help balance estrogen and progesterone levels, potentially alleviating symptoms of **PMS** and **menopause**. The oil’s effects on prostaglandin production may influence the menstrual cycle and alleviate discomfort associated with hormonal fluctuations. - **Improved skin hydration**: GLA helps improve the skin's ability to retain moisture, which is why primrose oil is often used topically for **eczema**, **psoriasis**, and other dry skin conditions. - **Neuroprotection**: Some studies suggest that GLA may have neuroprotective effects, potentially benefiting individuals with conditions like **diabetic neuropathy** and **multiple sclerosis** by reducing nerve inflammation and supporting overall nerve health.

Interaction

Several drug interactions are associated with **Primrose Oil**. It's important to discuss any current medications with your healthcare provider before starting primrose oil: - **Blood Thinners**: Primrose oil may interact with blood-thinning medications (such as **warfarin**, **aspirin**, or **clopidogrel**) and increase the risk of bleeding. - **Antihypertensive Medications**: It might interact with medications used to lower blood pressure, potentially enhancing the effects of these drugs, leading to low blood pressure. - **Antidiabetic Medications**: Some evidence suggests that primrose oil may affect blood sugar levels. It may interact with medications used to manage diabetes (such as insulin or oral hypoglycemics), potentially leading to hypoglycemia or changes in blood sugar control. - **Seizure Medications**: Individuals taking medication for seizure disorders should be cautious, as primrose oil may lower the seizure threshold, increasing the risk of seizures, particularly when used in high doses. Patients should also be mindful of **herbal interactions**, as some herbs (like **garlic** or **ginger**) may also act as blood thinners, which can lead to additive effects when taken with primrose oil.

Pregnancy Category Note

Information not available

Adult Dose

The standard dosage of **Primrose Oil** for adults varies depending on the condition being treated: - **For skin conditions** (e.g., eczema, psoriasis): A typical dose is **500–1,000 mg** of primrose oil, taken **1-3 times daily**. - **For PMS or menopausal symptoms**: **1,000–2,000 mg** per day in divided doses. - **For rheumatoid arthritis**: Doses of **1,500–3,000 mg** per day may be recommended, depending on the severity of symptoms. - **For heart health**: The general dose for supporting heart health or reducing cholesterol levels may range from **1,000–2,000 mg** per day. Patients should follow the specific dosage instructions given by their healthcare provider and avoid exceeding the recommended dose to minimize the risk of side effects.

Child Dose

The use of **Primrose Oil** in children should be carefully monitored and only administered under the guidance of a healthcare provider. Typical doses for children vary depending on age and the specific condition being treated, but it is usually recommended to start with **low doses**: - **For skin conditions**: If prescribed for eczema or dry skin, doses of **250–500 mg** per day are often used for children. - **For behavioral issues** (e.g., hyperactivity): In some cases, primrose oil may be used in children to support neurological health, with a dose of **500–1,000 mg** per day. Pediatric use should always be determined by a healthcare professional to avoid potential side effects and ensure safety.

Renal Dose

There are no specific dosage adjustments for **Primrose Oil** in patients with renal (kidney) impairment, as it is generally considered safe for use in those with mild to moderate kidney dysfunction. However, individuals with severe kidney impairment should consult their healthcare provider before using the oil. Monitoring kidney function during prolonged use may be advisable, especially in patients with additional comorbidities.

Administration

Information not available