Active Substance: Efavirenz.
Overview
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This medicine contains an important and useful components, as it consists of
Efavirenzis available in the market in concentration
Efavirenz
Mild to moderate liver disease; renal impairment. Monitor liver enzymes and cholesterol. Discontinue if severe skin rash or fever develops; known or suspected hepatitis B or infection. History of mental illness or seizures; elderly. Pregnancy. Children. Lactation: It is not known whether efavirenz is excreted in milk. It should not be administered to nursing mothers. The CDC advises HIV-infected women not to breast-feed to avoid postnatal transmission of HIV.
HIV infection
Severe hepatic impairment; hypersensitivity; lactation.
>10% Total cholesterol increased (20-40%),Diarrhea (3-14%, children up to 39%),HDL increased (25-35%),Dizziness (28.1%),Rash (5-26%),Fever (children 21%),Depression (19%),Insomnia (16.3%),Cough (children 16%),Vomiting (3-12%),Anxiety (2-13%),Nausea (2-12%) 1-10% Neutropenia (2-10%),Pruitis (9%),Impaired concentration (8.3%),Transaminases increased (2-8%),Somnolence (7.0%),Abnormal dreams (6.2%),Amylase increased (6%),Hyperglycemia (2-5%),Dyspepsia (4%),Abdominal pain (2-3%),Anorexia (2%),Hallucinations (1.2%)
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Efavirenz, a non-nucleoside reverse transcriptase inhibitor with activity against HIV, blocks the RNA-dependent and DNA-dependent polymerase activities including HIV replication.
Hormonal contraceptives; antibacterial e.g. rifampicin, rifabutin, clarithromycin; enzyme inducers. St. John's wort may decrease serum level. Ethanol (hepatic and CNS adverse effects). Potentially Fatal: Life-threatening adverse effects when used with terfenadine, astemizole, cisapride, midazolam, triazolam and ergot alkaloids.
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