Glibenclamide

Welcome to Dwaey, specifically on Glibenclamide page.
This medicine contains important and useful components, as it consists of
Glibenclamide is available in the market in concentration.

Generic Name of Glibenclamide - Learn More

Glibenclamide

Glibenclamide Precaution - What You Need to Know

Before using glibenclamide, it is crucial to consult with a healthcare provider to ensure it is appropriate for your specific health condition. Glibenclamide should be used cautiously in individuals with a history of hypersensitivity to sulfonylureas. This medication is also contraindicated in patients with severe renal or hepatic impairment, as these conditions can lead to the accumulation of the drug, potentially resulting in toxicity. Elderly patients and those with cardiovascular disease should use glibenclamide with caution, as sulfonylureas can increase the risk of heart-related issues. Additionally, patients should be monitored closely for hypoglycemia, particularly if they are on other medications that lower blood sugar. Pregnant and breastfeeding women should consult their healthcare provider before using glibenclamide, as it is generally not recommended during pregnancy due to potential risks to the fetus. Always adhere to the healthcare provider's instructions to prevent complications.

Glibenclamide Indication - Uses and Benefits

Glibenclamide is indicated for the treatment of type 2 diabetes mellitus. It is used in conjunction with diet and exercise to help lower blood glucose levels in individuals who cannot achieve adequate glycemic control with lifestyle modifications alone. Glibenclamide works by stimulating insulin secretion from the pancreas, which helps to reduce blood glucose levels. It is not recommended for the treatment of type 1 diabetes or diabetic ketoacidosis. Glibenclamide may also be prescribed alongside other antidiabetic agents when necessary, to achieve better control of blood glucose levels. Its use should be monitored regularly to assess its effectiveness and prevent complications.

Glibenclamide Contraindications - Important Warnings

Glibenclamide is contraindicated in patients with known hypersensitivity to sulfonylureas or any of the components of the drug. It should not be used in individuals with severe renal or hepatic impairment due to the potential for accumulation and toxicity. Additionally, glibenclamide is contraindicated in patients with diabetic ketoacidosis, as it is ineffective in managing this condition. It should not be used during pregnancy, particularly during the first trimester, due to potential risks to the fetus. People with a history of cardiovascular disease, particularly coronary artery disease, should use glibenclamide with caution. Always consult with a healthcare provider before starting this medication to ensure it is safe.

Glibenclamide Side Effects - What to Expect

Common side effects of glibenclamide include gastrointestinal symptoms such as nausea, heartburn, and bloating, as well as weight gain. The most significant and potentially dangerous side effect is hypoglycemia (low blood sugar), which can occur if the drug causes excessive insulin release. Symptoms of hypoglycemia include dizziness, shaking, sweating, confusion, and in severe cases, loss of consciousness or seizures. Other serious side effects include skin reactions, such as rash or itching, and in rare cases, blood disorders like leukopenia or thrombocytopenia. Long-term use may also increase the risk of cardiovascular events. It is essential to monitor blood glucose regularly to prevent hypoglycemia and report any unusual symptoms to a healthcare provider immediately.

Glibenclamide Pregnancy Category ID - Safety Information

3

Glibenclamide Mode of Action - How It Works

Glibenclamide is a sulfonylurea medication that helps to lower blood glucose levels by stimulating the pancreas to release insulin. It works by binding to specific receptors on the ATP-sensitive potassium channels (K_ATP channels) on pancreatic beta cells. This binding causes the channels to close, leading to depolarization of the cell membrane. The depolarization opens voltage-dependent calcium channels, allowing calcium to enter the cells, which triggers the release of insulin. The released insulin helps the body absorb glucose from the blood, thereby reducing blood glucose levels. This mechanism is particularly effective in patients with some residual pancreatic beta-cell function, which is common in type 2 diabetes.

Glibenclamide Drug Interactions - What to Avoid

Glibenclamide can interact with several other medications, which may alter its effectiveness or lead to adverse effects. Concomitant use with other antidiabetic medications, such as insulin or metformin, can increase the risk of hypoglycemia. Drugs like corticosteroids, thiazide diuretics, and sympathomimetic agents may reduce the effectiveness of glibenclamide by raising blood glucose levels. Conversely, alcohol can enhance the hypoglycemic effect of glibenclamide, increasing the risk of low blood sugar. Additionally, glibenclamide may interact with liver enzyme modulators, such as CYP2C9 inhibitors or inducers, which could alter the drug’s metabolism and efficacy. Patients should inform their healthcare provider about all other medications they are taking to avoid potentially harmful interactions.

Glibenclamide Adult Dose - Recommended Dosage

The starting dose of glibenclamide for adults is typically 2.5 mg to 5 mg once daily, taken with breakfast or the first main meal. Depending on the patient’s blood glucose levels and response to the medication, the dose may be adjusted. The usual maintenance dose ranges from 5 mg to 10 mg per day. The maximum recommended dose is 20 mg per day. It is important to monitor blood glucose levels regularly to assess the drug’s effectiveness and adjust the dose as needed. Glibenclamide should be taken with food to reduce the risk of stomach upset and improve its effectiveness.

Glibenclamide Child Dose - Dosage for Children

Glibenclamide is typically not recommended for use in children due to the lack of sufficient safety and efficacy data. In rare cases, if prescribed, the dose would be determined by the child’s healthcare provider based on the child's specific needs and weight. The typical starting dose for children, if necessary, would be lower than the adult dose and would be carefully monitored to avoid the risk of hypoglycemia. Parents or caregivers should closely follow the healthcare provider's instructions when administering glibenclamide to a child.

It is crucial that patients consult their healthcare provider before starting any medication, including glibenclamide, to ensure it is safe and appropriate for their condition. This helps prevent potential complications and ensures optimal treatment outcomes.

Glibenclamide Renal Dose - Dosage for Kidney Conditions

Glibenclamide should be used with caution in patients with renal impairment, as it is primarily excreted through the kidneys. In patients with moderate renal dysfunction, the dose may need to be reduced, and careful monitoring of blood glucose levels is recommended. In severe renal impairment, glibenclamide is generally not recommended, as the risk of accumulation and toxicity increases. Patients with kidney problems should consult their healthcare provider before using this medication to ensure that an appropriate dose adjustment is made and to monitor for any adverse effects.