Docetaxel

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Generic Name of Docetaxel - Learn More

Docetaxel

Docetaxel Precaution - What You Need to Know

- Allergic Reactions: Docetaxel can cause severe allergic reactions, including anaphylaxis. To prevent this, patients are often given steroid tablets before treatment. If you experience symptoms like difficulty breathing, swelling, hives, or rapid heartbeat, seek immediate medical help.
- Fluid Retention: Docetaxel can cause fluid retention, which may lead to swelling in the legs, feet, or hands. This usually occurs around the fifth dosing cycle. Monitor for signs of fluid retention and report them to your healthcare provider.
- Blood Cell Counts: Docetaxel can lower the number of white blood cells, increasing the risk of infection. It can also lower platelet counts, which are necessary for proper blood clotting. Regular blood tests are needed to monitor these levels.
- Hepatic Impairment: Docetaxel is metabolized by the liver, and patients with liver impairment may experience increased side effects. Dosage adjustments may be necessary for these patients.
- Pregnancy and Breastfeeding: Docetaxel can harm a developing fetus and should not be used during pregnancy unless clearly necessary. It is also not recommended during breastfeeding as it can pass into breast milk.
- Alcohol Content: Docetaxel contains alcohol, which can cause side effects in some patients, including drowsiness and dizziness. Use with caution in patients with a history of alcohol dependence or liver disease.
- Heart Problems: Elderly patients or those with pre-existing heart conditions should use docetaxel with caution, as it can exacerbate heart problems.
- Secondary Cancers: Docetaxel may increase the risk of developing secondary cancers, such as acute myeloid leukemia or myelodysplastic syndrome.

Docetaxel Indication - Uses and Benefits

- Breast Cancer: Docetaxel is used to treat locally advanced or metastatic breast cancer, often in combination with other chemotherapy drugs like doxorubicin and cyclophosphamide.
- Lung Cancer: Docetaxel is used to treat non-small cell lung cancer (NSCLC), particularly in patients with advanced or metastatic disease.
- Prostate Cancer: Docetaxel is used to treat metastatic castration-resistant prostate cancer, often in combination with prednisone.
- Stomach Cancer: Docetaxel is used to treat advanced gastric adenocarcinoma, often in combination with cisplatin and fluorouracil.
- Head and Neck Cancer: Docetaxel is used to treat locally advanced or metastatic head and neck cancer, often in combination with other chemotherapy drugs.
- Ovarian Cancer: Docetaxel is used to treat advanced ovarian cancer, often in combination with other chemotherapy drugs like carboplatin.

Docetaxel Contraindications - Important Warnings

- Hypersensitivity: Do not use docetaxel if you are allergic to it or any of its ingredients, including polysorbate 80, which is found in some medications.
- Severe Liver Impairment: Avoid use in patients with severe liver impairment, as docetaxel is metabolized by the liver and can cause increased side effects in these patients.
- Severe Neutropenia: Avoid use in patients with severe neutropenia (low white blood cell counts), as docetaxel can further lower these counts and increase the risk of infection.
- Pregnancy: Avoid use during pregnancy unless clearly necessary, as docetaxel can harm a developing fetus.
- Breastfeeding: Avoid use during breastfeeding, as docetaxel can pass into breast milk and may harm a nursing infant.

Docetaxel Side Effects - What to Expect

- Common Side Effects: These include hair loss, fatigue, nausea, vomiting, diarrhea, muscle pain, and joint pain. These side effects are usually manageable and may go away as your body adjusts to the medication.
- Severe Side Effects: These include allergic reactions, fluid retention, low blood cell counts, and peripheral neuropathy (numbness and tingling in the hands and feet). These side effects can be serious and require immediate medical attention.
- Hepatotoxicity: Docetaxel can cause liver damage, indicated by elevated liver enzymes. Regular liver function tests are needed to monitor for this side effect.
- Pneumotoxicity: Docetaxel can cause lung damage, indicated by shortness of breath and cough. This side effect requires immediate medical attention and may necessitate discontinuing the drug.
- Secondary Cancers: Docetaxel may increase the risk of developing secondary cancers, such as acute myeloid leukemia or myelodysplastic syndrome.

Docetaxel Pregnancy Category ID - Safety Information

4

Docetaxel Mode of Action - How It Works

- Microtubule Stabilization: Docetaxel works by binding to microtubules, which are structures involved in cell division. By stabilizing microtubules, docetaxel prevents cell division and promotes cell death, particularly in rapidly dividing cancer cells.
- Cell Cycle Arrest: Docetaxel arrests the cell cycle in the G2/M phase, preventing cells from dividing and leading to cell death. This effect is particularly pronounced in cancer cells, which divide more rapidly than normal cells.
- Apoptosis Induction: Docetaxel induces apoptosis, or programmed cell death, in cancer cells by disrupting the normal function of microtubules and preventing cell division.

Docetaxel Drug Interactions - What to Avoid

- CYP3A4 Inhibitors: Drugs that inhibit CYP3A4, such as ketoconazole, can increase the levels of docetaxel in the body, leading to increased side effects. Avoid or use alternate drugs.
- CYP3A4 Inducers: Drugs that induce CYP3A4, such as phenytoin, can decrease the levels of docetaxel in the body, making it less effective. Avoid or use alternate drugs.
- Immunosuppressives: Docetaxel can diminish the therapeutic effects of vaccines and increase the risk of adverse effects, including increased risk of infection.
- Other Chemotherapy Drugs: Docetaxel is often used in combination with other chemotherapy drugs, which can increase the risk of side effects. Close monitoring is required when used with other chemotherapy agents.
- Alcohol: Docetaxel contains alcohol, which can interact with other medications and increase side effects. Avoid alcohol while taking docetaxel.

Docetaxel Adult Dose - Recommended Dosage

- Intravenous Infusion: Docetaxel is administered as an intravenous infusion, typically over 1 hour. The dose and frequency depend on the type of cancer being treated and the patient's overall health.
- Breast Cancer: The typical dose is 60-100 mg/m² every 3 weeks, often in combination with other chemotherapy drugs like doxorubicin and cyclophosphamide.
- Lung Cancer: The typical dose is 75 mg/m² every 3 weeks, often in combination with other chemotherapy drugs like cisplatin.
- Prostate Cancer: The typical dose is 75 mg/m² every 3 weeks, often in combination with prednisone.
- Stomach Cancer: The typical dose is 75-100 mg/m² every 3 weeks, often in combination with cisplatin and fluorouracil.
- Head and Neck Cancer: The typical dose is 75 mg/m² every 3 weeks, often in combination with other chemotherapy drugs like cisplatin and fluorouracil.

Docetaxel Child Dose - Dosage for Children

- Limited Data: The safety and effectiveness of docetaxel in pediatric patients have not been established. Use in children should be under the close supervision of a healthcare provider.
- Dosage: If used in children, the dosage is typically based on body surface area and must be determined by a healthcare provider. Close monitoring is essential to adjust the dose based on individual response and tolerability.
- Medical Supervision: Any use of docetaxel in children should be closely monitored. Dosage adjustments may be necessary based on individual response and tolerance.

Docetaxel Renal Dose - Dosage for Kidney Conditions

- No Specific Adjustments: There are no specific guidelines for adjusting the dose of docetaxel in patients with renal impairment. However, as docetaxel is primarily metabolized by the liver, renal impairment is not expected to significantly affect its dosing.
- Monitoring: Patients with renal impairment should be monitored closely for side effects, as they may be more susceptible to adverse reactions. Dosage adjustments may be made based on individual response and tolerance.
- Consultation: Always consult your healthcare provider for personalized advice on docetaxel dosing if you have renal impairment. They may consider other factors, such as liver function and concomitant medications, when determining the appropriate dose.