Dexketoprofen

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Generic Name of Dexketoprofen - Learn More

Dexketoprofen

Dexketoprofen Precaution - What You Need to Know

Dexketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for pain and inflammation relief. As with other NSAIDs, it should be used cautiously in patients with gastrointestinal (GI) disorders such as peptic ulcer disease or a history of GI bleeding, as it can increase the risk of gastric ulceration and bleeding. Caution is also necessary for individuals with a history of cardiovascular disease, hypertension, or renal impairment, as NSAIDs, including dexketoprofen, may exacerbate these conditions. Prolonged use may increase the risk of heart attack, stroke, or renal damage. In patients with asthma, dexketoprofen should be used with caution, as it may provoke bronchospasm in sensitive individuals. It is contraindicated in patients with severe hepatic or renal impairment, as its metabolism and excretion may be affected. Pregnant women, especially in the third trimester, should avoid dexketoprofen due to its potential to cause fetal harm, including premature closure of the ductus arteriosus. It is not recommended for breastfeeding women, as it may pass into breast milk. Elderly patients may be more vulnerable to side effects, including gastrointestinal bleeding and kidney dysfunction, so careful monitoring is required. Patients should be advised to use the lowest effective dose for the shortest duration to minimize risks, especially when long-term therapy is needed.

Dexketoprofen Indication - Uses and Benefits

Dexketoprofen is primarily indicated for the management of acute pain, including pain from conditions such as musculoskeletal disorders, dental pain, and dysmenorrhea (painful menstruation). It is also commonly prescribed for post-operative pain and for treating pain associated with trauma, such as sprains or strains. As a potent anti-inflammatory analgesic, dexketoprofen is effective in reducing both pain and inflammation associated with conditions like osteoarthritis and rheumatoid arthritis, providing symptomatic relief. The drug's fast onset of action and relatively favorable side-effect profile compared to other NSAIDs make it suitable for short-term pain management. Off-label, dexketoprofen may also be used for treating other inflammatory conditions, though this is less common. It can be considered in certain soft tissue injuries and in the management of pain after minor surgical procedures, where its short-term use can help alleviate discomfort and reduce inflammation.

Dexketoprofen Contraindications - Important Warnings

Dexketoprofen should be avoided in patients with a known hypersensitivity to dexketoprofen, ketoprofen, or any other NSAIDs, as this can lead to serious allergic reactions such as anaphylaxis or severe skin reactions. It is contraindicated in individuals with active or a history of gastrointestinal bleeding, peptic ulcers, or inflammatory bowel disease, as NSAIDs can exacerbate these conditions and increase the risk of bleeding. Patients with severe liver or renal impairment should not use dexketoprofen, as the drug is metabolized in the liver and excreted via the kidneys, and these conditions can affect its clearance. It is also contraindicated in individuals with a history of significant cardiovascular diseases, such as recent myocardial infarction, stroke, or peripheral artery disease, due to the increased risk of adverse cardiovascular events with prolonged NSAID use. Additionally, dexketoprofen is contraindicated during the third trimester of pregnancy due to the risk of premature closure of the ductus arteriosus in the fetus. Patients with asthma, particularly those with aspirin-exacerbated respiratory disease, should avoid dexketoprofen, as it can provoke bronchospasm. The drug is also contraindicated in breastfeeding women, as it is excreted in breast milk.

Dexketoprofen Side Effects - What to Expect

The side effects of dexketoprofen are similar to those of other NSAIDs and are primarily related to gastrointestinal, renal, and cardiovascular systems. The most common side effects include dyspepsia (indigestion), abdominal pain, nausea, and mild headache. Gastrointestinal issues such as peptic ulcers, gastritis, and gastrointestinal bleeding are possible, particularly with long-term use. These risks can be reduced by using the lowest effective dose and avoiding prolonged therapy. Renal side effects, including fluid retention, decreased kidney function, and increased creatinine levels, may occur in patients with pre-existing renal conditions or those on long-term treatment. Cardiovascular risks such as increased blood pressure, fluid retention, and an elevated risk of heart attack or stroke are associated with prolonged use of dexketoprofen, particularly in those with pre-existing heart disease. Rare but serious side effects include allergic reactions such as urticaria (hives), angioedema (swelling), and anaphylaxis. Skin reactions, including rashes and photosensitivity, may also occur. Long-term use may lead to increased risk of bleeding, especially in patients taking anticoagulants. If any signs of gastrointestinal bleeding, such as black or tarry stools, or symptoms of an allergic reaction, such as difficulty breathing or swelling of the face, are experienced, medical attention should be sought immediately.

Dexketoprofen Pregnancy Category ID - Safety Information

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Dexketoprofen Mode of Action - How It Works

Dexketoprofen is an NSAID that works by inhibiting the activity of cyclooxygenase (COX), an enzyme responsible for the conversion of arachidonic acid into prostaglandins. Prostaglandins are lipid compounds that play a crucial role in the inflammatory process, causing pain, fever, and swelling. There are two main forms of cyclooxygenase: COX-1 and COX-2. Dexketoprofen primarily inhibits COX-1, which is involved in the production of prostaglandins that mediate inflammation and pain. It also inhibits COX-2 to a lesser extent, which plays a role in the inflammatory response. By blocking the production of these inflammatory mediators, dexketoprofen effectively reduces pain, inflammation, and fever. Its faster onset of action and more potent anti-inflammatory effects make it an effective agent for acute pain management. Dexketoprofen is the S-enantiomer of ketoprofen, which enhances its anti-inflammatory and analgesic properties while potentially offering a more favorable side-effect profile compared to racemic ketoprofen. Due to its COX-inhibiting action, dexketoprofen provides significant relief from conditions associated with pain and inflammation, though it still carries typical NSAID-related risks, especially with long-term use.

Dexketoprofen Drug Interactions - What to Avoid

Dexketoprofen can interact with several other medications, potentially increasing the risk of adverse effects or reducing therapeutic efficacy. When used with other anticoagulants, such as warfarin or heparin, dexketoprofen can increase the risk of bleeding due to its antiplatelet effects. Combining dexketoprofen with other NSAIDs, corticosteroids, or selective serotonin reuptake inhibitors (SSRIs) increases the risk of gastrointestinal bleeding and ulcers. Patients on antihypertensive medications, particularly ACE inhibitors, diuretics, or angiotensin II receptor blockers (ARBs), should be monitored for reduced effectiveness, as dexketoprofen can interfere with the blood pressure-lowering effects of these drugs. Concurrent use with lithium or methotrexate can increase plasma concentrations of these medications, raising the risk of toxicity. When combined with other drugs affecting renal function, such as certain diuretics or angiotensin-converting enzyme inhibitors, dexketoprofen may further impair renal function, potentially leading to acute kidney injury. Alcohol should be consumed cautiously, as both alcohol and NSAIDs can irritate the gastrointestinal lining, increasing the risk of ulcers and bleeding. Combining dexketoprofen with cyclosporine or other immunosuppressants can also increase the risk of kidney damage. Patients should avoid using dexketoprofen in combination with other drugs that increase the risk of GI bleeding, such as non-steroidal anti-inflammatory drugs (NSAIDs) or corticosteroids.

Dexketoprofen Adult Dose - Recommended Dosage

The typical adult dose of dexketoprofen for acute pain is 25 mg every 8 hours, not to exceed 75 mg per day. For conditions such as osteoarthritis, rheumatoid arthritis, or other inflammatory conditions, the standard dose is 25 mg three times a day. It is important to use the lowest effective dose for the shortest duration to minimize the risk of gastrointestinal, cardiovascular, and renal side effects. Dexketoprofen can be administered orally or parenterally, depending on the condition being treated and the patient's preference or clinical status. For patients who require rapid relief, an initial intravenous dose of 50 mg may be administered, followed by oral doses for maintenance. The drug should be taken with food to reduce the risk of gastrointestinal upset, although it should not be taken on an empty stomach. For chronic use, physicians should regularly assess the patient's response and risk factors, including renal and cardiovascular status, to determine the appropriate duration and dosage adjustments.

Dexketoprofen Child Dose - Dosage for Children

Dexketoprofen is generally not recommended for children under 12 years of age, as safety and efficacy in pediatric populations have not been well established. For children aged 12 years and older, the recommended dose is typically 25 mg every 8 hours, not to exceed 75 mg per day. In children with renal or hepatic impairment, dose adjustments should be made, and they should be closely monitored for adverse effects. Pediatric patients should be closely monitored for gastrointestinal, renal, and cardiovascular side effects, particularly if the drug is used for an extended period. Dexketoprofen should only be used in children when prescribed by a healthcare professional, and it is important to follow the prescribed dose and treatment duration to avoid potential risks.

Dexketoprofen Renal Dose - Dosage for Kidney Conditions

In patients with renal impairment, the use of dexketoprofen requires caution. In mild to moderate renal impairment (creatinine clearance between 30-60 mL/min), the usual dose should be reduced, and renal function should be monitored closely. It is generally recommended that dexketoprofen should not exceed 50 mg per day in these patients, and they should be closely observed for signs of renal dysfunction. In patients with severe renal impairment (creatinine clearance <30 mL/min), the use of dexketoprofen is contraindicated due to the risk of accumulation and potential renal toxicity. Since NSAIDs can reduce renal blood flow, dose reduction or discontinuation may be necessary, and patients should be monitored for any adverse renal effects, such as fluid retention or elevated creatinine levels. Adequate hydration and regular monitoring of renal function are critical in managing patients with renal concerns.