Alverine Citrate

Welcome to Dwaey, specifically on Alverine Citrate page.
This medicine contains important and useful components, as it consists of
Alverine Citrate is available in the market in concentration.

Generic Name of Alverine Citrate - Learn More

Alverine Citrate

Alverine Citrate Precaution - What You Need to Know

Alverine citrate is primarily used for the symptomatic relief of irritable bowel syndrome (IBS) and other gastrointestinal disorders characterized by abdominal discomfort and bloating. The medication works as a smooth muscle relaxant in the gastrointestinal tract. While alverine citrate is generally well tolerated, there are several important precautions to consider:
- Pregnancy and Breastfeeding: Alverine citrate is classified as Category C during pregnancy, meaning that its safety in pregnant women has not been established. It should only be used during pregnancy if the potential benefits outweigh the risks. There is limited data on the excretion of alverine citrate in breast milk, so caution is advised when using it in breastfeeding mothers.
- Gastrointestinal Disorders: Caution is needed in patients with gastrointestinal obstruction or severe constipation, as alverine citrate’s muscle-relaxing effects may exacerbate these conditions or mask symptoms of an underlying gastrointestinal issue.
- Liver and Renal Function: While not specifically contraindicated in liver or renal disease, hepatic or renal impairment patients should use alverine citrate under medical supervision, as the drug may be metabolized more slowly in these individuals, leading to a potential accumulation of the drug.
- Drug Interactions: There are no significant drug interactions identified with alverine citrate; however, it is advisable to avoid concomitant use with other anticholinergic agents or medications that affect gastrointestinal motility, as these may interfere with the desired therapeutic effects.

Monitoring Parameters:
- Gastrointestinal Function: Monitor for any signs of worsening constipation or abdominal bloating, especially during long-term use.
- Adverse Effects: Monitor for any side effects such as dizziness, dry mouth, or blurred vision, which may indicate anticholinergic effects.

Alverine Citrate Indication - Uses and Benefits

Alverine citrate is primarily indicated for the relief of irritable bowel syndrome (IBS), a condition characterized by symptoms such as abdominal pain, bloating, and altered bowel movements (diarrhea or constipation). It helps reduce smooth muscle spasm in the intestines, providing relief from cramping and discomfort.
- Functional Gastrointestinal Disorders: It can also be used for other conditions that involve smooth muscle spasm or dysmotility of the intestines.
- Although not officially approved for other uses, some off-label applications include chronic abdominal discomfort not related to IBS or as part of symptomatic management in patients with other conditions causing gastrointestinal spasm.

Alverine Citrate Contraindications - Important Warnings

- Hypersensitivity: Alverine citrate is contraindicated in patients with known hypersensitivity to alverine or any of the excipients in the formulation.
- Severe Constipation: Alverine citrate should not be used in patients with severe constipation or gastrointestinal obstruction, as the medication’s muscle-relaxant effects could worsen these conditions.
- Intestinal Perforation or Obstruction: In patients with a history of intestinal perforation or bowel obstruction, alverine citrate should be avoided as it could exacerbate symptoms or lead to further complications.

Alverine Citrate Side Effects - What to Expect

- Common Side Effects:
- Abdominal discomfort or mild gastrointestinal upset is common but generally resolves with continued use.
- Dizziness, drowsiness, or fatigue may occur, particularly if combined with other central nervous system depressants or alcohol.
- Dry mouth and blurred vision due to the mild anticholinergic effect of alverine citrate.
- Less Common Side Effects:
- Rashes or signs of allergic reactions like itching or swelling may occur in some patients.
- Headache or nausea has been reported in a minority of patients.
- Constipation or worsening of gastrointestinal symptoms may occur in some cases.
- Serious Side Effects: Severe side effects such as intense allergic reactions (e.g., difficulty breathing, swelling of the face or throat) are rare but require immediate medical attention.

Alverine Citrate Mode of Action - How It Works

Alverine citrate is a smooth muscle relaxant that primarily acts by inhibiting intestinal spasms. It exerts its therapeutic effects through:
- Calcium Channel Blockade: Alverine citrate inhibits calcium influx into smooth muscle cells, leading to relaxation of the smooth muscles of the gastrointestinal tract. This relaxation helps alleviate the cramping and pain associated with irritable bowel syndrome (IBS).
- Anticholinergic Properties: Although weak, alverine citrate exhibits some mild anticholinergic effects, which may contribute to its smooth muscle-relaxing properties by reducing involuntary muscle contractions in the bowel.
- Symptom Relief in IBS: By reducing muscle spasms and providing smooth muscle relaxation, it helps improve symptoms such as bloating, pain, and discomfort in IBS patients.

Alverine Citrate Drug Interactions - What to Avoid

- Anticholinergic Drugs: Alverine citrate has mild anticholinergic properties. When used concurrently with other anticholinergic medications, such as antihistamines, tricyclic antidepressants, or antimuscarinics, the anticholinergic effects (e.g., dry mouth, blurred vision, urinary retention) may be potentiated. Therefore, caution is advised when using alverine citrate with such drugs.
- Medications Affecting Gastrointestinal Motility: Caution should be exercised when alverine citrate is used with medications that alter gastrointestinal motility, such as laxatives or antidiarrheals, as these may counteract its intended effect.
- Alcohol: No significant interactions are noted between alverine citrate and alcohol. However, excessive alcohol consumption may exacerbate side effects like dizziness or drowsiness, so moderation is advised.

Alverine Citrate Adult Dose - Recommended Dosage

The standard adult dose for alverine citrate is:
- 1 capsule (60 mg) taken two to three times a day, depending on the severity of symptoms.
- The medication should be taken with food to minimize gastrointestinal irritation and enhance absorption.
- Dosing may be adjusted based on clinical response, with the maximum recommended dose being 180 mg per day.

Alverine Citrate Child Dose - Dosage for Children

Alverine citrate is not recommended for use in children, as safety and efficacy in pediatric populations have not been established. If used off-label in children, the dosing should be determined by a healthcare provider, with careful monitoring for adverse effects.

Alverine Citrate Renal Dose - Dosage for Kidney Conditions

There are no specific adjustments recommended for renal impairment with alverine citrate. However, in cases of significant renal dysfunction, caution is advised, as the elimination of the drug may be slower. Patients with impaired renal function should be monitored for side effects like dizziness or excessive drowsiness.