Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU.

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Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. is available in the market in concentration.

Generic Name of Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. - Learn More

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. Precaution - What You Need to Know

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU is a combination topical medication used to treat inflammatory and infectious skin conditions. It contains a potent corticosteroid (clobetasol), an antibiotic (neomycin), and an antifungal (nystatin). While the combination provides broad-spectrum action against inflammation, bacterial, and fungal infections, it should be used cautiously in certain populations. Prolonged or excessive use, especially over large areas of the skin, can lead to systemic absorption of the corticosteroid component, increasing the risk of side effects such as adrenal suppression, skin thinning, and delayed wound healing. It is advised that this medication not be applied to open or broken skin, as it may exacerbate infections or hinder healing. Additionally, due to the presence of neomycin, the risk of hypersensitivity reactions or contact dermatitis is higher in individuals with known sensitivities to aminoglycoside antibiotics. Caution is also warranted in patients with a history of skin infections, particularly viral or fungal infections, as clobetasol may mask these conditions. For pregnant or breastfeeding women, the drug should only be used when clearly needed and under medical supervision, as corticosteroids can pass into breast milk, and systemic absorption could pose risks. Routine monitoring for signs of secondary infections or corticosteroid-related side effects is important during therapy.

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. Indication - Uses and Benefits

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU is indicated for the treatment of mixed inflammatory and infectious dermatologic conditions. It is commonly prescribed for conditions such as eczema, psoriasis, and dermatitis that are complicated by bacterial or fungal infections. The combination of clobetasol, neomycin, and nystatin provides potent anti-inflammatory, antibacterial, and antifungal effects, making it highly effective for conditions where multiple pathogens are involved. Clobetasol, the corticosteroid component, reduces inflammation, itching, and redness, while neomycin works against bacterial infections, and nystatin targets fungal overgrowth. Off-label, it may be used for the treatment of other inflammatory or infectious skin conditions as directed by a healthcare provider. It is particularly beneficial in managing conditions where bacterial and fungal infections complicate an existing inflammatory dermatologic condition. Due to the high potency of clobetasol, this medication is generally reserved for short-term use to avoid the potential adverse effects associated with prolonged corticosteroid use.

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. Contraindications - Important Warnings

This combination product should not be used in patients with known hypersensitivity to clobetasol, neomycin, nystatin, or any other components of the formulation. It is contraindicated in individuals with bacterial, viral, or fungal skin infections not susceptible to the ingredients of the drug. Specifically, clobetasol should not be applied to active viral infections such as herpes simplex or chickenpox, as corticosteroids can exacerbate these conditions. Additionally, the presence of untreated systemic fungal infections should also exclude the use of this combination, as clobetasol may worsen such conditions. Neomycin, being an aminoglycoside, is contraindicated in individuals with a history of hypersensitivity or allergic reactions to aminoglycosides, as it may cause severe skin irritation or dermatitis. This medication is not recommended for use on the face, groin, or axillary areas unless specifically prescribed due to the risk of skin thinning in these sensitive areas. It is also contraindicated in children under the age of 12 years, unless specifically prescribed, due to the potential for systemic absorption of the corticosteroid, which can interfere with growth and cause other systemic effects. Pregnant and breastfeeding women should avoid using this product unless deemed absolutely necessary by their healthcare provider, as corticosteroids can be absorbed through the skin and potentially affect the fetus or infant.

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. Side Effects - What to Expect

The side effects of Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU can range from mild, localized reactions to more severe systemic effects, particularly with prolonged or excessive use. Common local side effects include burning, itching, dryness, or irritation at the application site. Long-term use, especially in sensitive areas or under occlusive dressings, may cause skin thinning (atrophy), stretch marks, or telangiectasia (visible blood vessels). There is also a risk of secondary bacterial or fungal infections due to the immunosuppressive effects of the corticosteroid, which may lead to worsening of the underlying condition. The antibiotic component, neomycin, can lead to allergic reactions or contact dermatitis in individuals with a sensitivity to aminoglycosides. In rare cases, systemic absorption of the corticosteroid can lead to side effects such as weight gain, fluid retention, elevated blood pressure, or suppression of the adrenal glands. In pediatric patients, there is an increased risk of growth suppression and other systemic corticosteroid effects. If any signs of infection, such as increased redness, swelling, or drainage from the treated area, appear, or if more severe allergic reactions like hives or difficulty breathing occur, medical attention should be sought immediately.

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. Pregnancy Category ID - Safety Information

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. Mode of Action - How It Works

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU combines three active ingredients to provide a multi-pronged approach to treating inflammatory and infectious skin conditions. Clobetasol Propionate, a potent corticosteroid, exerts its effects by binding to glucocorticoid receptors, inhibiting the release of inflammatory cytokines, and reducing the activity of phospholipase A2. This results in decreased inflammation, redness, and itching associated with inflammatory skin conditions. Neomycin, an aminoglycoside antibiotic, works by binding to bacterial ribosomes, inhibiting protein synthesis and thereby preventing bacterial growth. It is effective against a broad range of gram-negative and gram-positive bacteria, making it useful in treating secondary bacterial infections of the skin. Nystatin is an antifungal agent that binds to ergosterol, a component of the fungal cell membrane, causing pore formation and leading to the leakage of intracellular contents, which kills the fungus. Together, these components provide a comprehensive solution for inflammatory skin conditions complicated by bacterial or fungal infections, offering both anti-inflammatory and antimicrobial benefits.

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. Drug Interactions - What to Avoid

This combination medication may interact with other topical or systemic drugs, leading to either enhanced or diminished effects. When used with other corticosteroids, the risk of systemic side effects such as skin thinning, adrenal suppression, and delayed wound healing can increase. Concurrent use with other immunosuppressive therapies may also enhance the risk of infections due to the compounded immune-suppressive effects. Neomycin, an aminoglycoside, has the potential to interact with other antibiotics or medications that may alter renal function, increasing the risk of nephrotoxicity. Additionally, when used with other drugs that increase the permeability of the skin (e.g., alcohol-based preparations), clobetasol's systemic absorption may be heightened, leading to more pronounced corticosteroid side effects. Patients should also be cautious about using other antifungal agents or antibiotics concurrently, as interactions may affect the efficacy of treatment. Alcohol consumption does not have a significant effect on the topical use of this medication, but patients should be advised to avoid excessive sun exposure while using the drug, as corticosteroids can increase the risk of skin damage from UV rays.

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. Adult Dose - Recommended Dosage

For adults, the standard dosage of Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU topical is to apply a thin layer to the affected area of the skin once or twice daily, depending on the severity of the condition. The treatment duration should typically not exceed 2 weeks, as prolonged use of corticosteroids can result in adverse effects such as skin thinning and systemic absorption. This medication should be used sparingly, only on the affected areas, and should not be applied to large areas of the skin or for extended periods. The healthcare provider may adjust the dosing frequency based on the clinical response. If no improvement is seen after 2 weeks of use, alternative treatments or further evaluation should be considered.

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. Child Dose - Dosage for Children

For pediatric patients, the use of Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU should be approached with caution. The safety and efficacy of this combination medication in children under the age of 12 years have not been established. In children, especially those younger than 12, the use of clobetasol, a potent corticosteroid, carries a higher risk of systemic absorption and adverse effects such as growth retardation and adrenal suppression. Pediatric dosing should be determined by a healthcare provider, and the medication should be used for the shortest duration necessary. Application should be limited to affected areas, and treatment should be closely monitored. If any adverse effects such as skin thinning, growth suppression, or signs of systemic corticosteroid effects are observed, the medication should be discontinued.

Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU. Renal Dose - Dosage for Kidney Conditions

While Clobetasol Propionate 0.05% + Neomycin Sulphate 0.5% + Nystatin BP 1,00,000 IU has minimal systemic absorption when used topically, patients with renal impairment should still exercise caution, particularly with the neomycin component. Neomycin can be absorbed systemically, and in patients with pre-existing renal dysfunction, this could potentially lead to nephrotoxicity. It is advised to monitor renal function during therapy, especially if the medication is applied to large areas of the skin or for prolonged periods. If signs of systemic absorption or nephrotoxicity appear (e.g., changes in urine output, swelling, or weight gain), the medication should be discontinued, and alternative treatments should be considered.

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