Aluminium Chloride Hexahydrate 20%

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Generic Name of Aluminium Chloride Hexahydrate 20% - Learn More

Aluminium Chloride Hexahydrate 20% Precaution - What You Need to Know

Aluminum chloride hexahydrate 20% is primarily used as a topical treatment for hyperhidrosis (excessive sweating), especially for axillary (underarm) sweating. This medication should be used with caution in certain populations and conditions:
- Pregnancy and Breastfeeding: There is limited data regarding the safety of aluminum chloride hexahydrate during pregnancy. It is classified as a Category C drug, meaning it should be used only if the potential benefit justifies the risk to the fetus. Similarly, it is not known whether aluminum chloride passes into breast milk, so caution should be exercised when using this product during breastfeeding.
- Skin Sensitivity: The solution may cause irritation or allergic reactions, especially in patients with sensitive skin or those with a history of dermatitis or eczema. It is crucial to perform a patch test before widespread use to determine if the individual is prone to reactions.
- Open Wounds: The medication should not be applied to broken, irritated, or abraded skin, as it can lead to severe irritation and exacerbation of the condition.
- Use with Other Topical Treatments: Caution should be taken when using aluminum chloride hexahydrate concurrently with other topical treatments, as it can cause excessive irritation or reduce the efficacy of other medications.

Monitoring Parameters:
- Skin Reaction: Regular monitoring of the treated skin area for any signs of irritation or allergic reactions is recommended. If any severe irritation or burning occurs, use should be discontinued.
- Signs of Infection: If the skin becomes broken, infected, or shows signs of excessive redness or swelling, further treatment with aluminum chloride should be avoided until the skin heals.

Aluminium Chloride Hexahydrate 20% Indication - Uses and Benefits

Aluminum chloride hexahydrate 20% is mainly indicated for the treatment of primary axillary hyperhidrosis, where it is used to control excessive sweating. This topical agent works by blocking the sweat glands temporarily, thereby reducing the amount of sweat produced. It is effective in managing localized sweating in the underarms but may also be applied to other areas such as hands or feet for certain patients.

Off-label uses include treating plantar hyperhidrosis (excessive sweating of the feet), palmar hyperhidrosis (excessive sweating of the palms), and facial hyperhidrosis, although these uses are less common. It is typically prescribed when antiperspirants containing lower concentrations of aluminum compounds do not provide adequate results.

Aluminium Chloride Hexahydrate 20% Contraindications - Important Warnings

- Hypersensitivity to Aluminum Chloride: Patients with a known hypersensitivity to aluminum chloride or other aluminum-based compounds should avoid using this product.
- Open Wounds: Aluminum chloride hexahydrate should not be applied to broken, cut, or irritated skin as it can cause severe irritation and potentially worsen the condition.
- Severe Dermatological Conditions: In individuals with conditions like eczema or severe dermatitis, the product should be used with extreme caution or avoided entirely, as it can exacerbate these conditions.
- Children and Adolescents: This medication should be used cautiously in children, particularly in those under 12 years old, due to the potential for skin irritation and lack of extensive safety data.

Aluminium Chloride Hexahydrate 20% Side Effects - What to Expect

The most common side effects of aluminum chloride hexahydrate include:
- Skin Irritation: This is the most frequent side effect and can range from mild redness and stinging to more severe reactions like burning, itching, or peeling of the skin.
- Hyperpigmentation: Prolonged use may sometimes result in skin discoloration, particularly in areas where the medication has been applied frequently.
- Dryness: Excessive dryness or flaking of the skin is common and can worsen with extended use.
- Allergic Reactions: In rare cases, patients may experience more severe allergic reactions, including rash, swelling, or urticaria (hives).
- Sensitivity to Heat: Some users report heightened sensitivity to heat in the areas where the medication is applied, which could lead to discomfort in warmer environments.

To mitigate these side effects, patients should apply the medication sparingly and allow the skin to adjust. If irritation persists, it may be necessary to reduce the frequency of application or switch to a less concentrated formulation.

Aluminium Chloride Hexahydrate 20% Pregnancy Category ID - Safety Information

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Aluminium Chloride Hexahydrate 20% Mode of Action - How It Works

Aluminum chloride hexahydrate works by blocking the sweat glands and reducing sweating in the applied area. The mechanism involves the aluminum ions binding to the proteins in the sweat ducts, which causes the duct to become obstructed and prevents the secretion of sweat onto the skin’s surface.

When applied topically, the aluminum chloride solution creates a temporary plug within the sweat glands, reducing the amount of moisture produced. This process is dose-dependent, meaning that higher concentrations or more frequent applications can result in a greater reduction in sweating. Aluminum chloride also acts as an antiperspirant, reducing the production of sweat by constricting the sweat ducts and increasing the viscosity of sweat in the gland.

Aluminium Chloride Hexahydrate 20% Drug Interactions - What to Avoid

Aluminum chloride hexahydrate typically does not have significant systemic drug-drug interactions due to its topical administration and minimal systemic absorption. However:
- Other Topical Agents: When used in conjunction with other topical treatments, particularly those containing alcohol or strong acids, aluminum chloride may increase irritation or cause skin burns. It is best to use aluminum chloride separately from other skincare products.
- Other Antiperspirants: Combining this treatment with other antiperspirants or topical medications designed to treat sweating may result in excessive dryness, irritation, or loss of efficacy. It is recommended to avoid using multiple topical treatments at the same time.
- Alcohol Consumption: Although not a direct interaction, alcohol may exacerbate skin dryness or irritation, potentially increasing discomfort when using aluminum chloride.

Aluminium Chloride Hexahydrate 20% Adult Dose - Recommended Dosage

For axillary hyperhidrosis, the typical starting dose of aluminum chloride hexahydrate 20% is to apply the solution once daily to the affected areas, preferably at night, when the sweat glands are less active. The medication should be applied to dry skin, and the area should be left undisturbed overnight. After the first few applications, the frequency may be reduced to every other day or a few times per week, depending on the response and tolerance.

In cases of plantar or palmar hyperhidrosis, the same dosage regimen is followed, but application to the hands or feet may require longer drying time or careful consideration of skin sensitivity.

Aluminium Chloride Hexahydrate 20% Child Dose - Dosage for Children

Aluminum chloride hexahydrate 20% is generally not recommended for use in children under 12 years of age. For older children and adolescents, the use of this product should be done under strict medical supervision. The dosing for children would follow a similar regimen to adults, but careful monitoring for skin irritation and sensitivity is advised. Lower doses or alternate treatments may be considered in pediatric patients.

Aluminium Chloride Hexahydrate 20% Renal Dose - Dosage for Kidney Conditions

Since aluminum chloride hexahydrate is applied topically and has minimal systemic absorption, there are no specific dosing adjustments required for patients with renal impairment. However, patients with compromised kidney function should use the medication cautiously due to the potential for aluminum accumulation if systemic absorption increases, though this is rare with topical use.