Vardenafil

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Generic Name of Vardenafil - Learn More

Vardenafil

Vardenafil Precaution - What You Need to Know

Before starting Vardenafil, it is essential for patients to consult their healthcare provider to ensure the medication is appropriate for their specific condition. Key precautions include:
- Cardiovascular Conditions: Vardenafil can cause a drop in blood pressure, so it should be used with caution in patients with heart disease, high blood pressure, low blood pressure, or history of stroke. It should not be used in combination with nitrates (e.g., nitroglycerin), as the combination can cause a severe drop in blood pressure that may be life-threatening.
- Renal and Hepatic Impairment: Patients with severe renal or liver impairment should use Vardenafil with caution, as reduced liver or kidney function can affect the drug’s metabolism, increasing the risk of side effects.
- Eye Problems: Rarely, Vardenafil has been associated with vision changes, including blurred vision or sudden loss of vision in one or both eyes (due to non-arteritic anterior ischemic optic neuropathy or NAION). Patients should inform their healthcare provider if they have a history of eye conditions, particularly those with a risk of optic neuropathy.
- Priapism: A rare but serious side effect of Vardenafil is priapism (a prolonged and painful erection lasting more than 4 hours). Patients experiencing this should seek immediate medical attention to prevent permanent damage to the penis.
- Dehydration and Electrolyte Imbalance: Vardenafil should be used cautiously in patients who are dehydrated or have electrolyte imbalances, especially if they are undergoing vigorous physical activity or taking medications that affect fluid balance.

Vardenafil Indication - Uses and Benefits

Vardenafil is primarily used for the treatment of erectile dysfunction (ED), a condition characterized by the inability to achieve or maintain an erection sufficient for sexual activity. It belongs to the class of medications known as phosphodiesterase type 5 (PDE5) inhibitors, which work by relaxing the muscles and increasing blood flow to the penis during sexual arousal. Vardenafil is also occasionally used to treat pulmonary arterial hypertension (PAH) under medical supervision, as it helps to dilate blood vessels in the lungs, improving blood flow and reducing the workload on the heart.

Vardenafil Contraindications - Important Warnings

Vardenafil should not be used in the following situations:
- Nitrate Use: Vardenafil is contraindicated in patients taking nitrate medications (e.g., nitroglycerin, isosorbide dinitrate) for chest pain or heart conditions, as the combination can lead to a dangerous and sudden drop in blood pressure.
- Severe Liver Impairment: Vardenafil should not be used in individuals with severe liver conditions (e.g., cirrhosis), as this can significantly increase drug concentrations in the body, leading to increased risk of side effects.
- Severe Renal Impairment: Patients with severe kidney dysfunction (e.g., end-stage renal disease) should avoid Vardenafil unless prescribed by a healthcare provider, as the drug may accumulate and cause adverse effects.
- Hypersensitivity: Patients with a known allergy or hypersensitivity to Vardenafil or any of its ingredients should not take this medication.
- Severe Heart Conditions: Vardenafil should not be used in patients with severe heart problems, including those who have had a heart attack or stroke in the past 6 months, or those with uncontrolled arrhythmias, low blood pressure, or severe heart failure.

Vardenafil Side Effects - What to Expect

Common and severe side effects of Vardenafil include:
- Headache: One of the most common side effects, usually mild to moderate in intensity.
- Flushing: A feeling of warmth or redness, particularly in the face, neck, and chest, is a frequent side effect.
- Nasal Congestion: Patients may experience a stuffy or runny nose.
- Dizziness or Lightheadedness: Especially when standing up quickly, due to the blood pressure-lowering effects of Vardenafil.
- Indigestion: Mild digestive discomfort or heartburn can occur.
- Vision Changes: Some patients may experience temporary vision changes, such as blurred vision or a blue tint to vision, which should be reported to a healthcare provider.
- Priapism: A prolonged and painful erection lasting more than 4 hours is a medical emergency that can result in permanent damage to the penis if not treated immediately.
- Hearing Loss: Sudden hearing loss or ringing in the ears has been reported in rare cases.
- Chest Pain: Although rare, some patients may experience chest pain or discomfort, especially if combined with other medications.

Vardenafil Pregnancy Category ID - Safety Information

2

Vardenafil Mode of Action - How It Works

Vardenafil works by selectively inhibiting the phosphodiesterase type 5 (PDE5) enzyme in the penile tissue, which normally breaks down cyclic guanosine monophosphate (cGMP). When PDE5 is inhibited, the levels of cGMP rise, leading to relaxation of smooth muscle in the blood vessels of the penis. This results in increased blood flow to the penis during sexual arousal, enabling an erection. Vardenafil is effective only in the presence of sexual stimulation and does not cause an erection in the absence of such stimulation. Additionally, Vardenafil is used in the treatment of pulmonary arterial hypertension by relaxing the blood vessels in the lungs, which lowers blood pressure in the pulmonary arteries and reduces the workload on the heart.

Vardenafil Drug Interactions - What to Avoid

Vardenafil may interact with various medications, food, and other substances, which can affect its effectiveness or safety:
- Nitrates: Vardenafil should never be used with nitrate drugs, such as nitroglycerin, isosorbide dinitrate, or isosorbide mononitrate, as the combination can cause a life-threatening drop in blood pressure.
- Alpha-blockers: The use of Vardenafil with alpha-blockers (e.g., tamsulosin, doxazosin) used for high blood pressure or benign prostatic hyperplasia can enhance the blood pressure-lowering effects and increase the risk of dizziness, lightheadedness, or fainting.
- Antifungal and Antibiotic Medications: Drugs like ketoconazole (an antifungal) and clarithromycin (an antibiotic) can increase Vardenafil levels in the blood, potentially increasing the risk of side effects.
- HIV Protease Inhibitors: Medications such as ritonavir and indinavir, used to treat HIV, can increase the levels of Vardenafil in the blood, necessitating dose adjustments and careful monitoring.
- Rifampin: Rifampin, an antibiotic used to treat tuberculosis, may lower the effectiveness of Vardenafil by increasing the metabolism of the drug.
- Alcohol: Consuming large amounts of alcohol while taking Vardenafil can increase the risk of side effects such as dizziness, lightheadedness, and low blood pressure.

Vardenafil Adult Dose - Recommended Dosage

The typical adult dose for Vardenafil for erectile dysfunction is 10 mg, taken about 60 minutes before sexual activity. Depending on individual response and tolerance, the dose may be adjusted to 5 mg (if the 10 mg dose causes side effects) or increased to 20 mg (if the 10 mg dose is ineffective). The dose should not be taken more than once a day. It is important to avoid large amounts of alcohol or a high-fat meal before taking Vardenafil, as these may delay the onset of its effect. If taking Vardenafil for pulmonary arterial hypertension, the typical dose is 40 mg, taken once daily.

Vardenafil Child Dose - Dosage for Children

Vardenafil is not approved for use in children or adolescents under the age of 18. It is indicated only for adult use in the treatment of erectile dysfunction and pulmonary arterial hypertension. The safety and efficacy of Vardenafil in pediatric populations have not been established.

Vardenafil Renal Dose - Dosage for Kidney Conditions

For patients with mild to moderate renal impairment, no dose adjustment is necessary. However, for patients with severe renal impairment (e.g., creatinine clearance < 30 mL/min), the use of Vardenafil is not recommended, or it should be used with caution, and dose adjustments may be necessary depending on the severity of the condition.