Azilsartan Medoxomil

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Generic Name of Azilsartan Medoxomil - Learn More

Azilsartan Medoxomil

Azilsartan Medoxomil Precaution - What You Need to Know

Before starting Azilsartan Medoxomil, it is essential for patients to consult their healthcare provider to ensure the medication is appropriate for their specific condition. Key precautions include:
- Pregnancy: Azilsartan Medoxomil is contraindicated in pregnancy, especially in the second and third trimesters, due to the risk of fetal harm. The medication can cause renal dysfunction and hypotension in the fetus, leading to possible intrauterine death or malformations. Women who are pregnant or planning to become pregnant should avoid this drug.
- Renal Impairment: Patients with renal impairment should be monitored closely when taking Azilsartan Medoxomil, as it can cause acute kidney injury. Dosing adjustments may be necessary for individuals with mild to moderate renal impairment.
- Liver Dysfunction: Individuals with severe hepatic impairment should avoid Azilsartan Medoxomil due to the potential for accumulation of the drug in the system and the increased risk of side effects.
- Hypotension: Azilsartan Medoxomil can cause hypotension (low blood pressure), especially when treatment is initiated. Patients should be monitored for symptoms like dizziness, lightheadedness, or fainting, particularly if they are dehydrated or on diuretics.
- Hyperkalemia: Patients taking Azilsartan Medoxomil should be monitored for elevated potassium levels in the blood (hyperkalemia), which can lead to serious cardiac events if left unchecked. This is especially important for patients with kidney issues or those using other medications that increase potassium levels.
- Electrolyte Imbalance: Patients should undergo routine blood tests to check for electrolyte imbalances, including potassium and sodium levels, during treatment with Azilsartan Medoxomil.

Azilsartan Medoxomil Indication - Uses and Benefits

Azilsartan Medoxomil is primarily prescribed for the treatment of hypertension (high blood pressure). It is a angiotensin II receptor blocker (ARB) that works by relaxing blood vessels, allowing blood to flow more easily and thereby reducing blood pressure. By controlling blood pressure, Azilsartan Medoxomil helps reduce the risk of complications such as:
- Stroke
- Heart attack
- Kidney problems
- Heart failure

In some cases, Azilsartan Medoxomil may also be used in combination with other antihypertensive agents to provide better control of blood pressure.

Azilsartan Medoxomil Contraindications - Important Warnings

Azilsartan Medoxomil is contraindicated in the following conditions:
- Pregnancy: As mentioned earlier, it is contraindicated during pregnancy, particularly in the second and third trimesters, due to the risks of fetal harm and kidney damage.
- Severe Renal Impairment: Patients with severe renal impairment should avoid Azilsartan Medoxomil, as the drug may exacerbate kidney dysfunction.
- Hypersensitivity: Individuals with known hypersensitivity or allergy to Azilsartan Medoxomil or other angiotensin II receptor blockers (ARBs) should not take the drug due to the risk of severe allergic reactions.
- Concomitant use with Aliskiren: Azilsartan Medoxomil should not be used together with aliskiren (another antihypertensive medication) in patients with diabetes or renal impairment, as this combination may increase the risk of serious side effects such as kidney dysfunction and hyperkalemia.

Azilsartan Medoxomil Side Effects - What to Expect

Common and severe side effects of Azilsartan Medoxomil include:
- Hypotension: A common side effect, especially when starting treatment or when combined with other antihypertensive agents, is low blood pressure. Patients may experience symptoms such as dizziness, lightheadedness, or fainting.
- Hyperkalemia: Azilsartan Medoxomil can cause an increase in potassium levels, leading to hyperkalemia, which can result in arrhythmias or heart failure if severe.
- Kidney Dysfunction: Some patients may experience acute kidney injury, especially if they have pre-existing kidney conditions or are using other medications that affect kidney function.
- Dizziness or Lightheadedness: This side effect is often associated with the lowering of blood pressure and may cause difficulty standing up or performing normal activities.
- Fatigue: Some patients may feel unusually tired or weak while taking Azilsartan Medoxomil.
- Gastrointestinal Issues: Azilsartan Medoxomil may cause symptoms such as nausea, vomiting, or diarrhea in some individuals.
- Rashes and Allergic Reactions: Some people may develop skin rashes or experience angioedema (swelling of the deeper layers of the skin, especially around the eyes or lips), which may require discontinuation of the medication.

Azilsartan Medoxomil Pregnancy Category ID - Safety Information

4

Azilsartan Medoxomil Mode of Action - How It Works

Azilsartan Medoxomil is an angiotensin II receptor blocker (ARB) that works by blocking the effects of angiotensin II, a hormone that constricts blood vessels and increases blood pressure. By inhibiting the action of angiotensin II, Azilsartan Medoxomil:
- Dilates blood vessels, thereby lowering blood pressure.
- Reduces the secretion of aldosterone, a hormone that causes the kidneys to retain sodium and water, which could otherwise increase blood volume and blood pressure.
- It helps in controlling hypertension and reducing the risk of stroke, heart attack, and kidney damage associated with high blood pressure.

Azilsartan Medoxomil Drug Interactions - What to Avoid

Azilsartan Medoxomil may interact with several medications, food, or herbal products, including:
- Diuretics: When used together with diuretics (especially potassium-sparing diuretics), there is an increased risk of hyperkalemia (high potassium levels in the blood). This can cause severe heart issues. Monitoring potassium levels is essential during combination therapy.
- Other Antihypertensive Agents: Combining Azilsartan Medoxomil with other antihypertensive medications, such as ACE inhibitors or calcium channel blockers, can result in excessive blood pressure lowering, leading to hypotension. Careful dose adjustments may be required.
- Lithium: Azilsartan Medoxomil may increase the levels of lithium in the blood, leading to potential lithium toxicity. Regular monitoring of lithium levels is necessary when the two are used together.
- Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Long-term use of NSAIDs (e.g., ibuprofen, naproxen) can reduce the effectiveness of Azilsartan Medoxomil in lowering blood pressure and increase the risk of kidney damage. It is advisable to limit or avoid their use in combination with Azilsartan Medoxomil.
- Potassium Supplements: Azilsartan Medoxomil can increase the levels of potassium in the blood. When combined with potassium supplements or other potassium-sparing medications, this can lead to hyperkalemia and should be monitored carefully.
- Cyclosporine: Cyclosporine, an immunosuppressive drug, can increase the levels of Azilsartan Medoxomil in the bloodstream, potentially raising the risk of side effects. Adjustments to the medication dosage may be required.

Azilsartan Medoxomil Pregnancy Category Note - Key Information

Pregnancy Category: C (1st trimester); D (2nd and 3rd trimesters)

Azilsartan Medoxomil Adult Dose - Recommended Dosage

The recommended starting dose of Azilsartan Medoxomil for adults with hypertension is typically 40 mg once daily. If needed, the dose can be increased to 80 mg once daily to achieve better blood pressure control. It can be taken with or without food. Azilsartan Medoxomil is often used in combination with other antihypertensive agents, such as diuretics or calcium channel blockers, to provide additional blood pressure lowering effects.

Azilsartan Medoxomil Child Dose - Dosage for Children

Azilsartan Medoxomil is not recommended for use in pediatric patients under the age of 18, as safety and efficacy have not been established in this population. The drug is generally reserved for adult use in treating hypertension.

Azilsartan Medoxomil Renal Dose - Dosage for Kidney Conditions

For patients with mild to moderate renal impairment, Azilsartan Medoxomil can generally be used at the standard dose. However, patients with severe renal impairment (eGFR < 30 mL/min/1.73m²) should avoid this medication, or its use should be carefully monitored by a healthcare provider, as it may lead to further kidney deterioration.