Insulin degludec + Insulin aspart 70-30 premixed

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Generic Name of Insulin degludec + Insulin aspart 70-30 premixed - Learn More

Insulin degludec + Insulin aspart 70-30 premixed

Insulin degludec + Insulin aspart 70-30 premixed Precaution - What You Need to Know

Before using the Insulin Degludec + Insulin Aspart 70/30 Premixed formulation, it is crucial for patients to consult their healthcare provider to ensure this medication is suitable for their specific condition. Some important precautions to consider include:

- Hypoglycemia: Insulin use, including this premixed formulation, can lead to hypoglycemia (low blood sugar), especially if the dose is too high, meals are missed, or exercise is excessive. Patients should be aware of the signs of hypoglycemia (e.g., shaking, sweating, confusion) and be prepared to treat it promptly with glucose or other fast-acting carbohydrates.
- Hyperglycemia: Conversely, if the insulin dose is insufficient or the patient misses a dose, hyperglycemia (high blood sugar) may occur, leading to symptoms such as excessive thirst, frequent urination, or fatigue.
- Injection Site Reactions: As with any insulin injection, there may be injection site reactions, including redness, swelling, or pain. Rotating injection sites can help reduce the risk of such reactions.
- Alcohol Use: Alcohol can increase or decrease blood sugar levels, so it should be consumed cautiously, and patients should monitor their blood glucose levels closely when drinking alcohol.
- Kidney and Liver Function: Patients with impaired kidney or liver function should use Insulin Degludec + Insulin Aspart with caution, as renal or hepatic dysfunction may alter the way the body processes insulin, potentially requiring dose adjustments.

Insulin degludec + Insulin aspart 70-30 premixed Indication - Uses and Benefits

The Insulin Degludec + Insulin Aspart 70/30 Premixed formulation is typically used to manage Type 1 and Type 2 diabetes mellitus. It combines two types of insulin: Insulin Degludec (a long-acting insulin) and Insulin Aspart (a rapid-acting insulin), to provide both basal and prandial coverage. Its indications include:

- Type 1 Diabetes: In patients with Type 1 diabetes, who require both basal and mealtime insulin coverage, this premixed insulin formulation helps manage blood glucose levels effectively throughout the day.
- Type 2 Diabetes: For patients with Type 2 diabetes, especially those who have not achieved adequate blood sugar control with oral medications alone, this insulin mix can provide better glycemic control.
- Postprandial and Basal Control: The insulin aspart component provides rapid insulin action around mealtime, while the insulin degludec component offers a slow, steady release of insulin throughout the day, covering both basal (background) insulin needs and bolus (meal-related) needs.

This combination simplifies the insulin regimen by offering both rapid and long-acting insulin in a single injection.

Insulin degludec + Insulin aspart 70-30 premixed Contraindications - Important Warnings

Insulin Degludec + Insulin Aspart 70/30 Premixed is contraindicated in the following situations:

- Hypersensitivity: Patients who have a known allergy or hypersensitivity to either insulin degludec or insulin aspart, or any of the excipients in the formulation, should avoid using this medication.
- Severe Hypoglycemia: This medication is not suitable for patients with a history of severe hypoglycemia or those who have an episode of hypoglycemia that cannot be treated easily.
- Diabetic Ketoacidosis: Insulin therapy is not recommended as the sole treatment for diabetic ketoacidosis (DKA), a serious complication of diabetes that requires urgent medical treatment.
- Uncontrolled thyroid or liver disorders: Patients with uncontrolled thyroid disease or severe liver disease should use insulin with caution, as insulin sensitivity may be altered in such conditions.

Always consult with a healthcare provider before initiating therapy with this insulin formulation to ensure it is appropriate based on the patient's medical history.

Insulin degludec + Insulin aspart 70-30 premixed Side Effects - What to Expect

The most common side effects of Insulin Degludec + Insulin Aspart 70/30 Premixed are related to insulin therapy in general. These include:

- Hypoglycemia: The most significant risk associated with insulin use is hypoglycemia. Symptoms include shaking, sweating, dizziness, confusion, and weakness. Severe hypoglycemia can lead to seizures, unconsciousness, or even death if not treated promptly.
- Weight Gain: Weight gain is a common side effect associated with insulin use, as insulin promotes the storage of fat and can lead to an increase in appetite.
- Injection Site Reactions: Pain, redness, swelling, or irritation at the injection site can occur. It is advisable to rotate injection sites to reduce this risk.
- Edema (Swelling): Some patients may experience fluid retention, leading to swelling, particularly in the hands, feet, or ankles.
- Lipodystrophy: Repeated injections in the same area can cause changes in the skin and underlying tissue, such as lumps or pits (lipodystrophy). Rotating injection sites helps reduce this risk.

Rare but more serious side effects include:
- Allergic Reactions: Severe allergic reactions, such as difficulty breathing, rash, or swelling of the face, may occur. These require immediate medical attention.
- Severe Hypokalemia: Insulin use, especially in high doses, can lead to hypokalemia (low potassium levels), which can cause symptoms like muscle weakness, cramping, and irregular heart rhythms.

Insulin degludec + Insulin aspart 70-30 premixed Pregnancy Category ID - Safety Information

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Insulin degludec + Insulin aspart 70-30 premixed Mode of Action - How It Works

The Insulin Degludec + Insulin Aspart 70/30 Premixed formulation combines two types of insulin with different action profiles:

- Insulin Degludec: This is a long-acting insulin that has a very slow onset and provides a steady release of insulin over a 24-hour period. It helps control blood sugar levels throughout the day and night, providing the basal insulin needed for managing overnight and fasting blood glucose levels.
- Insulin Aspart: This is a rapid-acting insulin that starts working quickly after injection to manage blood sugar spikes that occur after meals. Its action peaks within 1-3 hours and lasts for 3-5 hours, making it suitable for covering prandial insulin needs.

Together, the combination provides both basal and bolus coverage in a single injection, allowing for more convenient and effective management of blood glucose levels throughout the day.

Insulin degludec + Insulin aspart 70-30 premixed Drug Interactions - What to Avoid

Insulin Degludec + Insulin Aspart 70/30 may interact with several medications, affecting the insulin's effectiveness or increasing the risk of side effects. Key interactions to consider include:

- Oral Antidiabetic Drugs: Concomitant use with oral hypoglycemic agents like sulfonylureas, metformin, or thiazolidinediones can enhance the risk of hypoglycemia. Adjustments to insulin dosing may be required.
- Beta-Blockers: Medications such as beta-blockers (e.g., propranolol) can mask the symptoms of hypoglycemia, making it harder for patients to recognize when their blood sugar is low.
- Corticosteroids: Corticosteroids (e.g., prednisone) can increase blood sugar levels, potentially requiring adjustments to insulin doses.
- Diuretics: Thiazide diuretics (e.g., hydrochlorothiazide) can increase blood sugar levels, and may reduce insulin effectiveness, requiring careful monitoring of blood glucose.
- Alcohol: Alcohol can both increase and decrease blood sugar levels, and patients using insulin should monitor their blood glucose more frequently when consuming alcohol.

Patients should inform their healthcare provider of all medications, including over-the-counter drugs and supplements, to avoid potential interactions.

Insulin degludec + Insulin aspart 70-30 premixed Adult Dose - Recommended Dosage

The recommended dosing of Insulin Degludec + Insulin Aspart 70/30 Premixed is highly individualized based on the patient’s blood glucose levels, insulin needs, and response to treatment. Typically:

- Starting Dose: The usual starting dose for an adult with Type 1 or Type 2 diabetes is based on the patient’s current insulin regimen and glucose levels, with the initial total daily dose usually ranging from 0.5 to 1.0 units per kg of body weight.
- Dosing Frequency: This insulin mix is typically administered once or twice daily, with adjustments made based on blood sugar levels, meal patterns, and activity levels.

It is essential that dosing be guided by a healthcare provider, with frequent blood glucose monitoring to adjust the dose as needed.

Insulin degludec + Insulin aspart 70-30 premixed Child Dose - Dosage for Children

The Insulin Degludec + Insulin Aspart 70/30 Premixed formulation is not typically recommended for children under the age of 18 unless otherwise directed by a healthcare provider. For pediatric patients, insulin therapy is often individualized based on age, weight, and insulin needs, with careful monitoring to adjust doses as necessary.

In general, children with Type 1 diabetes or Type 2 diabetes should receive insulin doses tailored to their specific requirements and be monitored by a pediatric endocrinologist to ensure proper glucose control and growth.

Insulin degludec + Insulin aspart 70-30 premixed Renal Dose - Dosage for Kidney Conditions

For patients with renal impairment, insulin dosing should be closely monitored. Renal dysfunction may alter the body's ability to metabolize and excrete insulin, which can increase the risk of hypoglycemia. In such cases:

- Patients with mild to moderate kidney disease may require no dose adjustments, but regular monitoring is essential.
- For patients with severe renal impairment, dose adjustments may be necessary to prevent hypoglycemia. It is crucial to monitor blood glucose levels more frequently and adjust insulin doses accordingly.