Isradipine

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Generic Name of Isradipine - Learn More

Isradipine

Isradipine Precaution - What You Need to Know

Before starting isradipine, it is essential to consult a healthcare provider to ensure its safety and suitability for your condition. This step helps to avoid potential adverse effects or interactions with other medications. Precautions should be observed as follows:

- Allergy: Patients with a known allergy to isradipine or other calcium channel blockers should not take this medication.
- Heart conditions: Those with heart failure, arrhythmias, or severe aortic stenosis should use isradipine with caution, as it may worsen these conditions.
- Liver issues: People with liver impairment may need dosage adjustments, as isradipine is metabolized in the liver.
- Pregnancy and breastfeeding: The safety of isradipine in pregnant or breastfeeding women has not been well-established. It should be used only if absolutely necessary and under the guidance of a healthcare provider.
- Interaction with medications: Always inform your healthcare provider about other medications, including over-the-counter drugs and supplements.

Isradipine Indication - Uses and Benefits

Isradipine is primarily prescribed to treat hypertension (high blood pressure). It works by relaxing the blood vessels, making it easier for the heart to pump blood. This helps reduce the risk of complications associated with high blood pressure, such as strokes, heart attacks, and kidney damage. It can be used alone or in combination with other antihypertensive agents to manage blood pressure more effectively.

Isradipine Contraindications - Important Warnings

Isradipine should not be used under the following conditions:

- Allergic reactions: Known hypersensitivity to isradipine or other calcium channel blockers.
- Severe low blood pressure (hypotension): Should not be used in patients with extremely low blood pressure.
- Sick sinus syndrome or heart block: Due to its effects on the heart, isradipine is contraindicated in individuals with certain heart rhythm disorders.
- Severe aortic stenosis: A condition where the aortic valve is narrowed, which can impair blood flow and worsen the patient's condition.

Isradipine Side Effects - What to Expect

While isradipine is generally well-tolerated, some patients may experience side effects, such as:

- Common side effects:
- Dizziness, particularly when standing up quickly.
- Headaches.
- Flushing (redness and warmth, especially on the face).
- Swelling (edema) of the feet, ankles, or hands.
- Fatigue or feeling unusually tired.

- Severe side effects (less common):
- Severe hypotension (low blood pressure), which may cause fainting or dizziness.
- Heart palpitations, including irregular or rapid heartbeats.
- Shortness of breath, especially with exertion.

Patients should report any of these side effects to their healthcare provider immediately, especially if they are severe or persistent.

Isradipine Pregnancy Category ID - Safety Information

3

Isradipine Mode of Action - How It Works

Isradipine is a calcium channel blocker that works by inhibiting calcium ions from entering smooth muscle cells in blood vessels. This action results in vasodilation (widening of the blood vessels), which lowers vascular resistance and helps decrease blood pressure. By relaxing the blood vessels, isradipine also reduces the workload on the heart, making it easier for the heart to pump blood effectively.

Isradipine Drug Interactions - What to Avoid

Isradipine may interact with the following:

- Medications:
- Dolasetron: Concurrent use can increase the risk of heart rhythm disturbances.
- Itraconazole: A potent antifungal that can increase isradipine levels, potentially leading to toxicity.
- Tizanidine: Using these together may cause an excessive drop in blood pressure.

- Food and Alcohol:
- Grapefruit Juice: May increase isradipine blood levels and intensify its effects.
- Alcohol: Can enhance the blood pressure-lowering effect of isradipine, leading to an increased risk of hypotension.

Isradipine Adult Dose - Recommended Dosage

The standard adult dose of isradipine is:

- Starting Dose: 2.5 mg taken orally once daily.
- Maintenance Dose: May be increased to 5 mg once daily depending on the individual's response and tolerability.
- Dosage adjustments may be required in specific cases such as those with liver impairments.

It is important for patients to follow their healthcare provider’s instructions closely regarding dosing and not exceed the recommended dose.

Isradipine Child Dose - Dosage for Children

The use of isradipine in pediatric patients is generally not recommended, as its safety and effectiveness in children have not been well-established. If a healthcare provider deems it necessary for a child, dosage would need to be individualized based on the child’s weight, age, and health condition. Always consult with a pediatrician before administering isradipine to a child.

Isradipine Renal Dose - Dosage for Kidney Conditions

For patients with renal impairment, isradipine should be used with caution. Since isradipine is metabolized in the liver, the dosing may not need significant adjustment in those with renal issues, but monitoring of kidney function is advised. It's essential to consult with a healthcare provider to determine the appropriate dosage in the case of renal dysfunction.