Terazosin

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Generic Name of Terazosin - Learn More

Terazosin

Terazosin Precaution - What You Need to Know

Before initiating treatment with Terazosin, it is important to consult a healthcare provider due to the following precautions:
- Orthostatic Hypotension: Terazosin can cause orthostatic hypotension (a sudden drop in blood pressure when standing up), especially after the first dose. This can lead to dizziness, fainting, or even falls. Patients should be cautioned about the potential for dizziness, and it is recommended to take the first dose before bedtime to reduce this risk.
- Heart Disease: Terazosin should be used cautiously in patients with a history of heart disease, including heart failure, arrhythmias, or valvular heart disease. As it can lower blood pressure, there is an increased risk of worsening heart conditions.
- Liver Dysfunction: Terazosin is metabolized by the liver, so patients with liver impairment (e.g., cirrhosis) should use this drug with caution. Regular monitoring of liver function is advised.
- Prostate Cancer: Caution is required in patients who have been diagnosed with prostate cancer, as Terazosin is used to treat symptoms of benign prostatic hyperplasia (BPH) and may mask the symptoms of prostate cancer.
- Kidney Function: While Terazosin does not typically require dosage adjustments for renal impairment, patients with severely reduced kidney function should be closely monitored.
- Allergy to Alpha-blockers: Terazosin belongs to the class of alpha-1 adrenergic blockers, so it is contraindicated in patients who have an allergy to alpha-blockers or any of the components of the drug.

Terazosin Indication - Uses and Benefits

Terazosin is primarily used for the treatment of:
- Benign Prostatic Hyperplasia (BPH): Terazosin is used to relieve symptoms of BPH, such as difficulty urinating, urgency, and the need to urinate frequently. It works by relaxing the smooth muscles in the bladder neck and prostate, making it easier to urinate.
- Hypertension (High Blood Pressure): Terazosin can also be used to lower high blood pressure. It works by relaxing blood vessels, allowing blood to flow more easily. It is often used in combination with other antihypertensive medications.

Terazosin Contraindications - Important Warnings

Terazosin should be avoided in the following situations:
- Hypersensitivity: Contraindicated in patients who are allergic to Terazosin or any component of the formulation.
- Severe Liver Disease: Patients with severe liver disease or hepatic impairment should avoid Terazosin, as the drug is metabolized by the liver.
- Severe Hypotension: Terazosin is contraindicated in patients with a history of severe hypotension or those who are hemodynamically unstable, as it can cause a significant drop in blood pressure.
- Pheochromocytoma: Terazosin should not be used in patients with pheochromocytoma, a rare tumor of the adrenal glands that causes excessive production of catecholamines.

Terazosin Side Effects - What to Expect

Terazosin may cause several side effects, ranging from mild to severe:
- Common Side Effects:
- Dizziness or lightheadedness: Often occurring when standing up quickly, especially after the first dose.
- Fatigue or tiredness.
- Headache.
- Nausea or mild stomach upset.
- Swelling of the ankles or feet due to fluid retention.
- Serious Side Effects:
- Severe Hypotension: Extreme low blood pressure, especially after the first dose or dose increase, can lead to fainting, dizziness, or even shock.
- Priapism: A rare but serious side effect that involves a painful erection lasting longer than 4 hours. Immediate medical attention is required.
- Heart Problems: In rare cases, Terazosin can cause arrhythmias (irregular heartbeat) or chest pain. Notify a healthcare provider if these symptoms occur.
- Syncope (Fainting): This can happen due to a sudden drop in blood pressure, especially after the first dose.
- Allergic Reactions: Terazosin may cause an allergic reaction such as a rash, swelling, or difficulty breathing.

Terazosin Pregnancy Category ID - Safety Information

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Terazosin Mode of Action - How It Works

Terazosin is an alpha-1 adrenergic blocker. It works by blocking the action of the neurotransmitter norepinephrine on the alpha-1 receptors found in the smooth muscles of the prostate, bladder neck, and blood vessels.
- In BPH, by blocking these receptors, Terazosin helps relax the smooth muscles of the prostate and bladder neck, which improves urine flow and reduces symptoms of BPH (e.g., difficulty urinating).
- In hypertension, Terazosin works by relaxing vascular smooth muscles in the blood vessels, allowing the blood to flow more freely, which helps lower blood pressure.

Terazosin Drug Interactions - What to Avoid

Terazosin may interact with several other drugs, including:
- Other Antihypertensive Medications: Concurrent use with other antihypertensive drugs (e.g., ACE inhibitors, diuretics) can result in an additive effect, leading to hypotension (low blood pressure). Blood pressure should be monitored regularly.
- Phosphodiesterase Inhibitors (e.g., Sildenafil): The combination of Terazosin with phosphodiesterase inhibitors (e.g., Viagra, Cialis) can cause significant hypotension. Patients should avoid using these drugs together.
- Cimetidine: The use of cimetidine (an H2 blocker used for ulcers) with Terazosin may increase the concentration of Terazosin in the blood, leading to an enhanced blood pressure-lowering effect and increased risk of side effects.
- Beta-blockers: Caution is required when combining Terazosin with beta-blockers (e.g., metoprolol, atenolol), as it may increase the risk of hypotension.
- NSAIDs: Nonsteroidal anti-inflammatory drugs (e.g., ibuprofen, naproxen) may reduce the blood pressure-lowering effect of Terazosin.

Terazosin Adult Dose - Recommended Dosage

The recommended starting dose of Terazosin for adults varies based on the condition being treated:
- For Hypertension: The usual starting dose is 1 mg once daily at bedtime, which can be gradually increased to a maximum dose of 20 mg per day, depending on the individual’s response and tolerance.
- For BPH: The typical starting dose is 1 mg once daily, usually taken at bedtime. It can be gradually increased to 5 mg or 10 mg once daily, depending on the patient’s response.
- For Both Conditions: The dose should always be adjusted based on the patient’s individual response, with careful monitoring of blood pressure during dose titration.

Terazosin Child Dose - Dosage for Children

Terazosin is not approved for use in children under 18 years of age. There is insufficient evidence to support its safety and efficacy in the pediatric population. Therefore, its use in children should be avoided unless explicitly prescribed by a healthcare provider.

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Terazosin is an effective medication for managing BPH and hypertension. However, due to its potential to cause significant drops in blood pressure, especially after the first dose, it should be used with caution. Regular monitoring of blood pressure, renal function, and liver function is important. Always consult a healthcare provider before starting Terazosin to ensure it is safe and appropriate for your specific condition.

Terazosin Renal Dose - Dosage for Kidney Conditions

No major dose adjustments are required for patients with mild to moderate renal impairment. However, caution is advised in those with severe renal impairment. It is recommended to start at a lower dose (e.g., 1 mg) and titrate carefully under medical supervision.