PARACETAMOL MacoPharma 10mg/ml (500mg/50ml) Infusion/Solution for

This IV form allows for prompt serum concentrations and fast analgesic/antipyretic effect, ideal in emergency, perioperative, and critical care situations.

How to use PARACETAMOL MacoPharma 10mg/ml (500mg/50ml)

This medication is strictly for administration by qualified healthcare professionals within a hospital or similar facility.

• Visual Check: Ensure solution is clear, colorless, and free from particles; discard compromised bags.
• Dilution: Typically administered directly—no dilution needed—over a 15‑minute infusion period.
• Delivery: Use a dedicated IV line to avoid interactions with other drugs; confirm compatibility if using a multi‑lumen catheter.
• Schedule: Dosing is every 4–6 hours, guided by pain and fever relief without breaching daily limits.
• Single‑use: Do not refrigerate or reuse leftover solution; discard after use.
• Vitals Monitoring: Monitor blood pressure during infusion and assess pain and temperature pre‑ and post‑dose.

Follow institutional protocols and physician prescriptions for safe, effective administration.

Mode of Action PARACETAMOL MacoPharma 10mg/ml (500mg/50ml)

Paracetamol acts primarily within the central nervous system, with minimal peripheral inflammation effect:

• COX Enzyme Inhibition: Reversibly inhibits COX‑2 and possibly COX‑3 in the CNS, reducing prostaglandin synthesis involved in pain and fever.
• Thermoregulation: Influences hypothalamic centers to promote heat loss, reducing fever.
• Modulation of Pain Pathways: May enhance endogenous analgesic systems—including serotonergic and endocannabinoid pathways—to help blunt pain perception.
• Peripheral Safety: Does not significantly affect peripheral COX, preserving gastric mucosa and platelet function.

IV infusion achieves peak drug levels quickly, typically within 5–15 minutes, ideal for fast symptom relief in acute settings.

PARACETAMOL MacoPharma 10mg/ml (500mg/50ml) Interactions PARACETAMOL MacoPharma 10mg/ml (500mg/50ml)

Paracetamol exhibits few interactions, but certain drugs and conditions may increase risks:

• Enzyme Inducers: Rifampicin, carbamazepine, and phenytoin may accelerate paracetamol metabolism, elevating hepatotoxic risk.
• Alcohol: Chronic consumption depletes glutathione, amplifying liver injury, even at therapeutic levels.
• Warfarin and Anticoagulants: Long-term use may potentiate anticoagulant effect—INR monitoring advised.
• Isoniazid: Concomitant use can increase liver toxicity potential.
• Cholestyramine: May decrease paracetamol absorption if administered shortly beforehand.
• Probenecid: Can reduce clearance—dosage assessment recommended.

Always disclose all medications and supplements to healthcare professionals to avoid unexpected interactions.

Dosage of PARACETAMOL MacoPharma 10mg/ml (500mg/50ml)

Dose based on body weight and clinical judgment:

• Adults & Adolescents ≥50 kg: 500 mg (1 bag) over 15 minutes; repeat every 4–6 hours, not exceeding 2 g/day in standard inpatient care.
• Children/Adolescents 10–50 kg: 15 mg/kg per dose; max 60 mg/kg/day.
• Infants <10 kg: Use 7.5 mg/kg per dose; up to 30 mg/kg/day.
• Renal/Hepatic Impairment: Consider dose reduction or extend dosing interval.

Infusion should last at least 15 minutes to minimize side effects. Doses exceeding 2 g/day require liver function and risk reassessment.

Possible side effects of PARACETAMOL MacoPharma 10mg/ml (500mg/50ml)

IV paracetamol is generally well tolerated, but may cause adverse events:

• Common: Mild nausea, vomiting, headache, infusion-site irritation.
• Less common: Transient hypotension, flushing, mild elevation in transaminases.
• Rare but serious: Anaphylaxis, bronchospasm, severe rash, liver toxicity in overdose, hematologic effects such as thrombocytopenia or neutropenia.

Monitor during and after infusion—especially vital signs and liver enzymes—with immediate attention to signs of hypersensitivity or hepatic dysfunction.

PARACETAMOL MacoPharma 10mg/ml (500mg/50ml) Contraindications PARACETAMOL MacoPharma 10mg/ml (500mg/50ml)

Avoid use when:

• Hypersensitivity: Known allergy to paracetamol or any formulation components.
• Severe hepatic impairment: Including acute or chronic liver failure.
• Severe renal insufficiency: Use with caution and reduce dosage as needed.
• Severe malnutrition or alcoholism: Elevated hepatotoxic risk due to depleted glutathione.
• Concurrent use of other potent hepatotoxins: Weigh benefits versus potential harm.

Premature infants and neonates should only receive this under strict specialist direction.

Storage of PARACETAMOL MacoPharma 10mg/ml (500mg/50ml)

To preserve integrity, store as follows:

• Temperature: Keep between 15–25 °C; avoid freezing.
• Light Shielding: Store bags in original cartons—protect from direct sunlight.
• Inspection: Check each bag for clarity and absence of particulates before use.
• After Opening: Single-use only—discard any leftover fluid.
• Expiration: Discard bags past printed expiry date.
• Disposal: Follow institutional clinical waste protocols for safe disposal.
• Safety: Secure storage to prevent unauthorized access.