PANTOZYN 20 Tablets/Gastro-Resistant

What is PANTOZYN 20

PANTOZYN 20 is a prescription medication that contains Pantoprazole (as sodium sesquihydrate) at a strength of 20 mg per tablet. It is classified under a group of medicines known as proton pump inhibitors (PPIs), which work by reducing the amount of acid produced in the stomach. PANTOZYN 20 is typically used for the treatment and prevention of acid-related gastrointestinal conditions.

• Active Ingredient: Pantoprazole sodium sesquihydrate equivalent to 20 mg Pantoprazole
• Form: Gastro-resistant tablet
• Packaging: 30 tablets (10s Blister × 3)
• Indications:
  • Gastroesophageal reflux disease (GERD)
  • Functional dyspepsia
  • Prevention of NSAID-induced gastric ulcers
  • Maintenance therapy following healing of erosive esophagitis

How to use PANTOZYN 20

PANTOZYN 20 should be used exactly as directed by your healthcare provider. The gastro-resistant formulation ensures that the active ingredient bypasses the acidic environment of the stomach and is released in the intestines for effective absorption.

• Route of Administration: Oral
• Dosage Timing: Take 30–60 minutes before meals, preferably before breakfast
• Tablet Handling: Do not chew, crush, or split the tablet. Swallow whole with water.
• Missed Dose: If you forget to take a dose, take it as soon as you remember. Skip it if it’s close to the next dose—do not double up.
• Compliance Tips:
  • Take at the same time daily for best results
  • Notify your doctor if symptoms persist or worsen after several days of use
  • Avoid alcohol, smoking, and NSAIDs unless approved by your doctor

Mode of Action PANTOZYN 20

Pantoprazole, the active ingredient in PANTOZYN 20, is a proton pump inhibitor that acts on the parietal cells of the stomach lining to inhibit acid secretion. Its action helps in alleviating symptoms related to excessive stomach acid and facilitates healing of acid-related damage.

• Target Enzyme: H⁺/K⁺-ATPase (proton pump) in gastric parietal cells
• Action Mechanism:
  • Irreversibly binds to the proton pump
  • Suppresses the final step in gastric acid production
• Onset & Duration:
  • Onset of relief: Within 1–2 hours
  • Maximum effect: Seen within 2–3 days of continuous dosing
  • Duration: Acid suppression lasts 24 hours or more
• Therapeutic Impact:
  • Reduces heartburn and regurgitation
  • Heals erosive damage to the esophagus or stomach lining
  • Prevents ulcer recurrence in at-risk patients

PANTOZYN 20 Interactions PANTOZYN 20

PANTOZYN 20 may interact with various medications, influencing their absorption, metabolism, or efficacy. These interactions are mostly due to its effect on stomach pH and cytochrome P450 enzyme activity.

• Drugs with pH-dependent Absorption:
  • Antifungals (e.g., Ketoconazole, Itraconazole): Decreased absorption
  • HIV Protease Inhibitors (e.g., Atazanavir): Significantly reduced levels; avoid combination
• CYP Enzyme Substrates:
  • Warfarin: Potential increased bleeding risk; monitor INR
  • Clopidogrel: Reduced effectiveness; clinical significance varies
• Other Interactions:
  • Methotrexate: Risk of increased toxicity when used at high doses
  • Digoxin: Monitor serum levels in elderly or renal impairment

Dosage of PANTOZYN 20

The recommended dosage of PANTOZYN 20 varies based on the condition being treated. It should always be used under medical supervision to ensure optimal therapeutic outcomes and minimal risk of side effects.

• Adults:
  • GERD (mild/moderate): 20 mg once daily for 4–8 weeks
  • Maintenance therapy: 20 mg once daily
  • Prevention of NSAID-induced ulcers: 20 mg once daily
• Children (≥5 years, ≥15 kg): Use only under pediatric guidance with adjusted dosage
• Elderly: No dose adjustment generally required, unless with hepatic impairment
• Renal Impairment: Dose adjustment not required but monitor for adverse reactions
• Hepatic Impairment: Use with caution and under close monitoring

Possible side effects of PANTOZYN 20

Most people tolerate PANTOZYN 20 well. However, like all medicines, it may cause some side effects, ranging from mild to severe. Medical attention should be sought if any side effect becomes persistent or troublesome.

• Common Side Effects:
  • Headache
  • Nausea
  • Flatulence
  • Diarrhea or constipation
  • Abdominal discomfort
• Uncommon but Serious Side Effects:
  • Skin rashes or allergic reactions
  • Dizziness or visual disturbances
  • Changes in liver enzymes (ALT/AST)
  • Clostridium difficile infection in prolonged use
• Long-term Use Risks:
  • Vitamin B12 deficiency
  • Low magnesium levels (hypomagnesemia)
  • Bone fractures (hip, spine, or wrist)
  • Kidney disease (interstitial nephritis)

PANTOZYN 20 Contraindications PANTOZYN 20

PANTOZYN 20 should not be used in certain individuals due to the risk of adverse outcomes or lack of safety data. Always disclose your full medical history before starting therapy.

• Absolute Contraindications:
  • Known allergy to Pantoprazole or other PPIs
  • Hypersensitivity to any tablet components
• Relative Contraindications (use with caution):
  • Severe liver dysfunction
  • Osteoporosis or history of fractures
  • Vitamin B12 or magnesium deficiency
  • Concomitant use with atazanavir or nelfinavir

Storage of PANTOZYN 20

Proper storage ensures that PANTOZYN 20 maintains its efficacy and safety until its expiration date. Keep the medication in its original packaging to protect it from environmental factors.

• Temperature: Store below 25°C (77°F)
• Humidity: Keep away from moisture and damp environments
• Light: Protect from direct light by storing in original blister packs
• Child Safety: Store out of reach of children and pets
• Disposal: Do not flush or throw in household waste. Follow local regulations or consult a pharmacist for proper disposal
• Expiry: Do not use after the expiry date printed on the label