PANTOZOL I.V. 40mg Injection/Powder for

What is PANTOZOL I.V. 40mg

PANTOZOL I.V. 40mg is a proton pump inhibitor (PPI) containing Pantoprazole as its active ingredient, presented in the form of a powder for solution for intravenous injection. It is used to treat gastrointestinal conditions that involve excessive stomach acid production, particularly when oral administration is not feasible.

• Active Ingredient: Pantoprazole sodium sesquihydrate
• Form: Dry powder for injection (reconstituted before use)
• Strength: 40mg per vial
• Route: Intravenous

It is commonly prescribed for:

• Peptic ulcers
• Gastroesophageal reflux disease (GERD)
• Zollinger-Ellison syndrome and other pathological hypersecretory conditions
• Stress ulcer prophylaxis in critically ill patients

PANTOZOL I.V. is typically used when patients cannot take oral medication due to nausea, vomiting, or postoperative status. It helps reduce gastric acid secretion and protects the stomach lining.

How to use PANTOZOL I.V. 40mg

PANTOZOL I.V. 40mg must be administered by a healthcare professional in a hospital or clinical setting. The powder is reconstituted with a specific volume of saline or glucose solution to prepare it for intravenous administration.

• Reconstitution: Dissolve the contents of the vial in 10 mL of 0.9% sodium chloride or 5% glucose solution.
• Administration method: Intravenous injection or slow infusion (usually over 2 to 15 minutes)
• Frequency: Typically once daily; however, may vary depending on the condition being treated.

Important usage considerations:

• Ensure the solution is clear and free from particles before administration.
• Use reconstituted solution immediately or within a few hours if stored properly.
• Do not administer with other injectable drugs in the same IV line.

The use of this medication should be closely monitored for effectiveness and possible adverse reactions, especially in long-term therapy.

Mode of Action PANTOZOL I.V. 40mg

Pantoprazole, the active ingredient in PANTOZOL I.V., acts as a selective and irreversible proton pump inhibitor. It specifically targets the H+/K+-ATPase enzyme system located in the parietal cells of the gastric mucosa.

• Inhibits the final step of gastric acid secretion regardless of the stimulus (e.g., histamine, acetylcholine, gastrin).
• Blocks acid production at the source, reducing both basal and stimulated acid output.
• Forms a covalent bond with proton pumps, leading to long-lasting inhibition (up to 24 hours).

This mechanism allows PANTOZOL to:

• Promote healing of acid-related mucosal damage
• Relieve symptoms of acid reflux, such as heartburn and regurgitation
• Prevent complications such as ulcer bleeding or esophagitis

The onset of acid suppression is rapid, often noticeable within an hour of administration. Full therapeutic effects may be achieved within 1 to 2 days of consistent dosing.

PANTOZOL I.V. 40mg Interactions PANTOZOL I.V. 40mg

Pantoprazole may interact with several other medications, affecting either its efficacy or that of the co-administered drug. Caution is advised when co-prescribing with the following:

• Drugs requiring acidic pH for absorption:
  • Ketoconazole, itraconazole, atazanavir – reduced absorption and effectiveness
• Anticoagulants:
  • Warfarin – increased risk of bleeding; monitor INR closely
• Clopidogrel:
  • Potential reduction in antiplatelet effect; consider alternatives in high-risk cardiovascular patients
• Methotrexate:
  • High-dose methotrexate may accumulate, leading to toxicity
• Digoxin:
  • Risk of increased digoxin levels with prolonged PPI use

No significant interactions are noted with food, but intravenous use eliminates this concern. Always inform your healthcare provider of all concurrent medications, including over-the-counter and herbal products.

Dosage of PANTOZOL I.V. 40mg

The typical dosage of PANTOZOL I.V. 40mg is:

• Adults: 40 mg once daily via slow IV injection or infusion over 2 to 15 minutes

Dosage adjustments may be required in the following cases:

• Severe hepatic impairment: Consider dose reduction or extended dosing intervals
• Elderly patients: No dose adjustment needed, but monitor for adverse effects
• H. pylori eradication regimens: Typically not used intravenously; oral therapy is preferred

Duration of treatment:

• Short-term use in hospitalized patients (e.g., 7 to 10 days)
• Switch to oral pantoprazole when the patient can tolerate it

Always follow your doctor’s instructions regarding dose and duration to avoid under- or over-treatment.

Possible side effects of PANTOZOL I.V. 40mg

While generally well-tolerated, PANTOZOL I.V. can cause side effects. These are typically mild and transient, but some may require medical attention.

• Common:
  • Headache
  • Diarrhea or constipation
  • Nausea or vomiting
  • Injection site reactions (pain, redness, swelling)
• Less common:
  • Dizziness
  • Abdominal discomfort
  • Flatulence
• Rare but serious:
  • Hypomagnesemia (muscle cramps, arrhythmias)
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Liver enzyme elevation or hepatitis
  • Interstitial nephritis

Long-term use of proton pump inhibitors may be associated with:

• Increased risk of fractures
• Vitamin B12 deficiency
• Gastrointestinal infections (e.g., Clostridioides difficile)

Patients should report persistent or serious symptoms to their physician promptly.

PANTOZOL I.V. 40mg Contraindications PANTOZOL I.V. 40mg

PANTOZOL I.V. should not be used in the following cases:

• Known hypersensitivity to Pantoprazole, other substituted benzimidazoles, or any component of the formulation
• Severe hepatic dysfunction without appropriate monitoring
• Concomitant use with rilpivirine-containing medications (due to pH-dependent absorption)

Use with caution in:

• Patients with a history of allergic reactions to PPIs
• Patients at risk for osteoporosis or fractures
• Prolonged treatment requiring regular evaluation

Not typically recommended for children or adolescents due to limited data on safety and efficacy in pediatric IV use.

Storage of PANTOZOL I.V. 40mg

• Storage temperature: Store the unopened vials below 25°C (77°F); protect from light and moisture.
• Reconstituted solution: Should be used immediately after preparation. If necessary, it may be stored for a few hours at room temperature, but discard if discolored or particles are present.
• Shelf life: Check the expiration date on the vial packaging. Do not use expired medication.
• Handling: Only trained personnel should handle and reconstitute the medication.

Do not freeze the solution. Proper disposal procedures must be followed for unused or expired medication according to local regulations.