PANTOZOL 40mg Tablets/Gastro-Resistant

What is PANTOZOL 40mg

PANTOZOL 40mg is a gastro-resistant tablet containing Pantoprazole (as sodium sesquihydrate), which belongs to a class of medications known as proton pump inhibitors (PPIs). These medications reduce the amount of acid produced in the stomach, making them effective for the treatment of various acid-related gastrointestinal disorders.

• Used primarily for the treatment of gastroesophageal reflux disease (GERD), a condition where stomach acid frequently flows back into the esophagus.
• Effective in treating conditions such as erosive esophagitis, peptic ulcers, and Zollinger-Ellison syndrome (a rare condition involving excessive stomach acid production).
• Often prescribed to prevent ulcers in patients taking NSAIDs (non-steroidal anti-inflammatory drugs) long-term.

PANTOZOL 40mg offers symptom relief from heartburn, acid regurgitation, and pain due to ulcers. Its gastro-resistant formulation ensures the active ingredient is released in the intestine, protecting it from degradation in the acidic stomach environment.

How to use PANTOZOL 40mg

To ensure the optimal effectiveness of PANTOZOL 40mg, it should be taken with care and consistency as per your healthcare provider’s instructions.

• Take the tablet approximately 30 to 60 minutes before a meal, preferably breakfast.
• Swallow the tablet whole with water; do not crush or chew it, as it is gastro-resistant and designed to dissolve in the intestine.
• The dosage and duration depend on the condition being treated. For example:
  • GERD: Typically 40mg once daily for 4–8 weeks.
  • Ulcers: A similar regimen may apply, depending on severity.
• If a dose is missed, take it as soon as you remember, but do not double up if it’s near the next dose time.

Always follow the doctor’s instructions and complete the full course of treatment, even if symptoms improve early.

Mode of Action PANTOZOL 40mg

Pantoprazole, the active ingredient in PANTOZOL 40mg, works by targeting and inhibiting the gastric H⁺/K⁺-ATPase enzyme system (proton pump) in the parietal cells of the stomach.

• This proton pump is responsible for the final step in the production of gastric acid.
• By irreversibly binding to the proton pumps, pantoprazole significantly reduces both basal and stimulated acid secretion.
• The reduction in gastric acidity promotes healing of acid-related damage to the stomach and esophagus lining.
• The onset of action is usually within an hour, with maximal acid suppression occurring after several days of continuous use.

This targeted mechanism makes pantoprazole effective with minimal systemic effects, particularly useful in chronic acid suppression therapies.

PANTOZOL 40mg Interactions PANTOZOL 40mg

Pantoprazole may interact with several medications due to its influence on gastric pH and liver enzyme pathways.

• Drugs affected by pH:
  • Ketoconazole, itraconazole: Reduced absorption due to decreased gastric acidity.
  • Atazanavir, nelfinavir (antivirals): Significantly reduced bioavailability; avoid co-administration.
• CYP450 interactions:
  • Warfarin: May increase bleeding risk due to altered metabolism. Monitor INR closely.
  • Clopidogrel: May reduce the antiplatelet effect. Use with caution.
• Others:
  • Digoxin: Absorption may be increased; monitor levels.
  • Methotrexate: High-dose methotrexate can lead to toxicity; consider temporarily withholding pantoprazole.

Always inform your doctor of all medications, supplements, and herbal products you are using before starting PANTOZOL 40mg.

Dosage of PANTOZOL 40mg

The dosage of PANTOZOL 40mg varies depending on the condition being treated and the patient's age and medical history.

• GERD (Gastroesophageal Reflux Disease):
  • Standard dose: 40mg once daily for 4 to 8 weeks.
• Peptic Ulcer Disease:
  • Typically 40mg daily for 4 to 8 weeks.
• Zollinger-Ellison Syndrome:
  • Initial dose: 40mg twice daily; dose adjusted based on acid output.
• NSAID-induced ulcers:
  • 40mg daily for prevention or treatment.

Dose adjustments may be necessary for patients with liver impairment. Pediatric dosing must be guided strictly by a healthcare professional.

Possible side effects of PANTOZOL 40mg

While PANTOZOL 40mg is generally well-tolerated, some individuals may experience side effects. These are usually mild and transient but can occasionally be serious.

• Common side effects:
  • Headache
  • Diarrhea
  • Nausea or vomiting
  • Flatulence
  • Abdominal pain
• Less common but significant effects:
  • Joint or muscle pain
  • Dizziness
  • Sleep disturbances
• Rare but serious reactions:
  • Severe allergic reactions including anaphylaxis
  • Stevens-Johnson Syndrome or toxic epidermal necrolysis
  • Low magnesium levels (especially with long-term use)
  • Clostridioides difficile-associated diarrhea

Report any unusual or persistent side effects to your doctor immediately.

PANTOZOL 40mg Contraindications PANTOZOL 40mg

PANTOZOL 40mg should not be used in certain conditions due to the risk of adverse outcomes.

• Hypersensitivity: Contraindicated in patients with known allergy to pantoprazole, substituted benzimidazoles, or any component of the formulation.
• Co-administration with specific antivirals:
  • Avoid with drugs like atazanavir and nelfinavir due to significantly reduced efficacy of these antivirals.
• Caution advised in:
  • Severe liver disease – monitor closely.
  • Osteoporosis or risk of fractures – long-term use may affect bone density.
  • Vitamin B12 deficiency – prolonged use may impair absorption.

Pregnant and breastfeeding women should use the medication only if clearly needed and prescribed by a physician.

Storage of PANTOZOL 40mg

Proper storage of PANTOZOL 40mg is essential to maintain its potency and safety.

• Store at a temperature not exceeding 25°C (77°F).
• Keep the tablets in their original blister packaging to protect from light and moisture.
• Do not refrigerate or freeze.
• Keep out of reach of children and pets.
• Do not use after the expiry date stated on the pack.
• Discard unused or expired tablets responsibly in accordance with local pharmaceutical waste guidelines.

Always check the packaging for specific storage instructions and consult your pharmacist for any doubts regarding storage conditions.