PANTONIX 40mg I.V. Infusion/Powder for

What is PANTONIX 40mg I.V.

PANTONIX 40mg I.V. is a proton pump inhibitor (PPI) used in the treatment of gastrointestinal conditions caused by excessive stomach acid. It contains Pantoprazole (as sodium sesquihydrate) and is administered via intravenous infusion, typically in a hospital or clinical setting. This formulation is intended for short-term use when oral administration is not feasible.

• Indications: It is commonly prescribed for conditions such as gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and erosive esophagitis associated with acid reflux.
• Form: Sterile powder for intravenous infusion, reconstituted with a suitable diluent before administration.
• Patient population: Adult patients who require short-term IV therapy for acid-related conditions.
• Onset of action: Rapid onset after IV administration with effects beginning within an hour.

PANTONIX 40mg I.V. provides a reliable and effective method of acid suppression in patients unable to take medications orally, especially during acute hospital care.

How to use PANTONIX 40mg I.V.

PANTONIX 40mg I.V. should only be administered by healthcare professionals, typically in a hospital or clinical setting. The powder must be properly reconstituted and diluted before infusion.

• Reconstitution: The powder in the vial is reconstituted with 10 mL of 0.9% sodium chloride injection or another compatible diluent.
• Dilution: The reconstituted solution should then be further diluted in 100 mL of 0.9% sodium chloride or 5% dextrose solution before administration.
• Administration route: Administer as a slow intravenous infusion over 15 minutes.
• Monitoring: Vital signs and gastrointestinal symptoms should be monitored throughout treatment to assess efficacy and detect adverse effects.
• Important notes:
  • Do not mix with other drugs in the same infusion line unless compatibility is confirmed.
  • Use aseptic technique to avoid contamination.
  • Inspect the solution for particles or discoloration before use.

Dosage and frequency depend on the condition being treated and the patient's clinical response. Transition to oral therapy is recommended once the patient can tolerate oral intake.

Mode of Action PANTONIX 40mg I.V.

PANTONIX 40mg I.V. works by inhibiting the final step of gastric acid production in the stomach lining. It specifically targets and blocks the H⁺/K⁺ ATPase enzyme system—also known as the "proton pump"—within gastric parietal cells.

• Enzyme inhibition: Pantoprazole irreversibly binds to the proton pumps, suppressing the secretion of hydrochloric acid into the gastric lumen.
• Effectiveness: Acid suppression begins within an hour of administration and reaches maximum effect within 2 to 3 hours.
• Duration of action: Although it has a short plasma half-life (~1 hour), its effect lasts up to 24 hours due to irreversible enzyme inhibition.
• Restoration: Normal acid secretion resumes only after new proton pumps are synthesized by the body.

This mechanism provides both immediate and prolonged acid suppression, making it highly effective in the treatment and prevention of acid-related gastrointestinal conditions, especially when oral administration is not feasible.

PANTONIX 40mg I.V. Interactions PANTONIX 40mg I.V.

Pantoprazole may interact with other medications, potentially affecting their absorption, metabolism, or effectiveness. It's important to consider these interactions when co-administering drugs.

• Drugs affected by gastric pH:
  • Ketoconazole, itraconazole, atazanavir: Reduced absorption due to decreased stomach acidity.
  • Iron salts: May have reduced bioavailability.
• Anticoagulants:
  • Warfarin: May increase INR and risk of bleeding; close monitoring is advised.
• Clopidogrel: Pantoprazole may reduce the activation of clopidogrel, although it is considered less inhibitory than omeprazole.
• HIV medications: PPIs may reduce serum concentrations of certain antiretrovirals (e.g., rilpivirine, nelfinavir).
• Methotrexate: High-dose methotrexate levels may increase due to decreased renal clearance when co-administered with PPIs.

Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, before starting PANTONIX 40mg I.V.

Dosage of PANTONIX 40mg I.V.

The dosage of PANTONIX 40mg I.V. is individualized based on the patient's condition, severity, and response to treatment. It is used primarily for short-term treatment when oral therapy is not possible.

• Standard dosage: 40 mg once daily via slow intravenous infusion over 15 minutes.
• Indication-based adjustment:
  • GERD or erosive esophagitis: 40 mg/day for up to 7-10 days, followed by a switch to oral therapy.
  • Zollinger-Ellison syndrome or hypersecretory conditions: Initial dose of 80 mg/day; doses can be titrated up to 240 mg/day in divided doses depending on acid output.
• Renal impairment: No dosage adjustment needed.
• Hepatic impairment: Use with caution; prolonged treatment may require liver function monitoring.
• Elderly patients: No specific adjustment, but careful monitoring is advised.

Treatment duration should be the shortest possible to control symptoms, with a switch to oral therapy as soon as the patient is able to swallow tablets or capsules.

Possible side effects of PANTONIX 40mg I.V.

Most patients tolerate PANTONIX 40mg I.V. well, but like all medications, it can cause side effects. These are usually mild and transient but can occasionally be serious.

• Common side effects:
  • Headache
  • Nausea or vomiting
  • Diarrhea or constipation
  • Injection site reactions (pain, redness, swelling)
• Less common effects:
  • Dizziness or fatigue
  • Flatulence
  • Rash or itching
• Serious side effects (rare):
  • Hypomagnesemia (low magnesium levels)
  • Anaphylactic reactions
  • Liver enzyme elevation or hepatitis
  • Interstitial nephritis

If any signs of allergic reaction, such as difficulty breathing, swelling, or severe rash occur, immediate medical attention is necessary.

PANTONIX 40mg I.V. Contraindications PANTONIX 40mg I.V.

PANTONIX 40mg I.V. is generally safe but should be avoided in certain conditions where its use could lead to harm or lack of benefit.

• Known hypersensitivity: Contraindicated in patients allergic to pantoprazole, other substituted benzimidazoles, or any of the formulation components.
• Co-administration with rilpivirine: This combination is contraindicated due to significantly reduced efficacy of rilpivirine.
• Severe hepatic impairment: Use cautiously; prolonged use may require close monitoring of liver function.
• Pregnancy and lactation: Should be used only if clearly needed; consult a physician before use in pregnant or breastfeeding women.

Patients with a history of severe allergic reactions to proton pump inhibitors or with uninvestigated gastrointestinal symptoms (e.g., weight loss, vomiting) should undergo diagnostic testing before starting pantoprazole therapy.

Storage of PANTONIX 40mg I.V.

Proper storage of PANTONIX 40mg I.V. is essential to maintain its sterility and effectiveness.

• Unopened vial: Store below 25°C (77°F), away from moisture, heat, and direct sunlight.
• Reconstituted solution: Should be used immediately after preparation, but can be stored for up to 12 hours at room temperature if necessary.
• Diluted solution: Use within 12 hours after further dilution into the IV infusion bag.
• Do not freeze: Freezing the vial or solution may lead to degradation or loss of potency.
• Disposal: Discard any unused portion safely according to local regulations for pharmaceutical waste.

Keep out of reach of children and ensure that reconstitution and administration are performed using sterile, aseptic techniques in clinical environments.