PANTOLIFE 40mg Capsules (Hard Gelatin)/Gastro-Resistant

What is PANTOLIFE 40mg

PANTOLIFE 40mg is a proton pump inhibitor (PPI) used to reduce the amount of acid produced in the stomach. It contains Pantoprazole sodium sesquihydrate as its active ingredient and is available in hard gelatin, gastro-resistant capsule form. Each capsule is specially formulated to bypass the acidic environment of the stomach and dissolve in the intestine, ensuring targeted delivery and maximum efficacy.

• Therapeutic Class: Proton Pump Inhibitor (PPI)
• Indications: PANTOLIFE is commonly prescribed for:
  • Gastroesophageal reflux disease (GERD)
  • Erosive esophagitis
  • Peptic ulcers
  • Zollinger-Ellison syndrome
  • Prevention of NSAID-associated gastric ulcers
• Form: Hard gelatin, gastro-resistant capsules
• Pack Size: 28 capsules (14-capsule blister × 2)

How to use PANTOLIFE 40mg

Proper usage of PANTOLIFE 40mg ensures optimal effectiveness and minimizes the risk of side effects. Always follow your healthcare provider’s instructions closely.

• Administration:
  • Take the capsule whole, with a glass of water.
  • Do not chew or crush the capsule to preserve its gastro-resistant coating.
  • Take the medicine at least 30–60 minutes before meals, preferably in the morning.
• Consistency: Use at the same time each day for best results.
• Missed Dose: If you forget a dose, take it as soon as you remember. If it's close to the next dose, skip the missed one. Never double up.
• Duration: Treatment duration depends on your condition. GERD may require 4–8 weeks, while Zollinger-Ellison syndrome may require long-term use under supervision.

Important: Do not discontinue PANTOLIFE suddenly without medical advice, especially in chronic conditions.

Mode of Action PANTOLIFE 40mg

Pantoprazole, the active ingredient in PANTOLIFE 40mg, is a proton pump inhibitor (PPI) that selectively blocks the hydrogen/potassium ATPase enzyme system in gastric parietal cells.

• Mechanism:
  • Inhibits the final step of gastric acid production by irreversibly binding to H⁺/K⁺-ATPase enzyme.
  • Suppresses both basal and stimulated acid secretion.
• Onset and Duration:
  • Onset of action typically within 1 hour of oral administration.
  • Peak effect observed in about 2 hours.
  • Duration of acid suppression can last up to 24 hours.
• Benefits:
  • Reduces acid-related symptoms like heartburn, regurgitation, and pain.
  • Promotes healing of acid-induced inflammation and ulcers.

This targeted action makes PANTOLIFE effective and reliable for both short-term and long-term acid suppression therapy.

PANTOLIFE 40mg Interactions PANTOLIFE 40mg

PANTOLIFE 40mg may interact with other drugs, altering their efficacy or increasing the risk of side effects. Inform your healthcare provider of all medications, including OTC and herbal supplements.

• Drugs with Absorption Affected by pH:
  • Ketoconazole, Itraconazole, Atazanavir, and Erlotinib: Absorption is reduced due to higher gastric pH.
• Anticoagulants and Antiplatelets:
  • Warfarin: May increase INR and bleeding risk.
  • Clopidogrel: Pantoprazole may reduce its antiplatelet effect slightly, but clinical relevance is debated.
• Enzyme Interactions:
  • Minimal inhibition of CYP enzymes, but caution with drugs metabolized by CYP2C19 and CYP3A4 (e.g., diazepam).
• Others:
  • Methotrexate: High-dose methotrexate toxicity may increase with PPI use.
  • Iron salts and Vitamin B12: Absorption may be impaired with prolonged use.

Dosage of PANTOLIFE 40mg

The dosage of PANTOLIFE 40mg depends on the indication, severity of the condition, and individual patient response. Always use under medical supervision.

• Adults:
  • GERD/Erosive Esophagitis: 40mg once daily for 4–8 weeks. An additional 8-week course may be considered.
  • Maintenance Therapy: 20–40mg daily as needed.
  • Zollinger-Ellison Syndrome: Start with 40mg twice daily. Adjust based on acid output and symptom control.
• Children (under 18 years): Not routinely recommended unless prescribed by a pediatric specialist.
• Renal Impairment: No dose adjustment required.
• Hepatic Impairment: Use with caution; dose adjustment may be necessary in severe cases.
• Elderly Patients: No specific adjustment, but monitor for response and adverse effects.

Capsules should be swallowed whole and taken before meals for maximum effectiveness.

Possible side effects of PANTOLIFE 40mg

While generally well tolerated, PANTOLIFE 40mg may cause side effects in some individuals. These effects are typically mild and reversible.

• Common Side Effects:
  • Headache
  • Diarrhea or constipation
  • Nausea or vomiting
  • Flatulence
  • Abdominal pain
• Uncommon Side Effects:
  • Dizziness
  • Joint pain or muscle cramps
  • Sleep disturbances
• Rare but Serious Reactions:
  • Hypomagnesemia (especially with prolonged use)
  • Vitamin B12 deficiency
  • Allergic reactions (rash, angioedema)
  • Liver enzyme elevation or hepatitis
  • Clostridioides difficile infection (due to suppressed stomach acid)

Report any persistent or severe symptoms to a healthcare provider promptly.

PANTOLIFE 40mg Contraindications PANTOLIFE 40mg

Not all patients are suitable candidates for PANTOLIFE 40mg therapy. It should be avoided in the following conditions:

• Known Hypersensitivity:
  • Allergy to pantoprazole, other PPIs, or any capsule excipients.
• Severe Hepatic Dysfunction:
  • Use with extreme caution; regular liver function monitoring is advised.
• Concomitant Atazanavir Use:
  • Inappropriate due to reduced bioavailability of the antiviral.
• Pediatric Use:
  • Safety and efficacy not well established for children under 18 years unless specifically prescribed.

Always consult with a physician before starting PANTOLIFE, especially if underlying medical conditions exist.

Storage of PANTOLIFE 40mg

Proper storage ensures the stability and efficacy of PANTOLIFE 40mg capsules.

• Temperature: Store below 25°C (77°F).
• Humidity: Keep in a dry place, away from moisture.
• Packaging: Store in original blister pack to protect from light and humidity.
• Child Safety: Keep out of reach of children.
• Expiry: Do not use after the expiry date printed on the blister pack.

Do not store in the bathroom or near a sink. Do not freeze. Proper disposal of unused medication is recommended—consult your pharmacist.