PANALIFE 500mg Tablets

What is PANALIFE 500mg

PANALIFE 500mg is a widely used analgesic and antipyretic medication, containing Paracetamol (Acetaminophen) as its active ingredient. Each tablet delivers 500mg of paracetamol, designed to relieve mild to moderate pain and reduce fever. PANALIFE is commonly used for:

• Headaches and migraines
• Muscle aches and back pain
• Toothache
• Menstrual cramps
• Arthritis-related pain (non-inflammatory)
• Fever associated with cold or flu

The product comes in a pack of 24 tablets (2 blisters of 12 tablets), making it suitable for short-term use or for households seeking a convenient over-the-counter remedy for everyday aches and pains.

How to use PANALIFE 500mg

Proper usage of PANALIFE 500mg is essential for safe and effective relief. Follow these guidelines for optimal results:

• Adults and children over 12 years: Take 1–2 tablets (500mg–1000mg) every 4–6 hours as needed.
• Maximum daily dose: Do not exceed 8 tablets (4000mg) in 24 hours.
• Children under 12 years: This strength is not recommended. Use an appropriate lower dose formulation.
• Tablets should be swallowed whole with a full glass of water. Do not crush or chew.
• Always leave at least 4 hours between doses.
• Use the lowest effective dose for the shortest possible duration.

Consult your doctor or pharmacist if pain or fever persists for more than 3 days, or if new symptoms appear.

Mode of Action PANALIFE 500mg

Paracetamol, the active ingredient in PANALIFE 500mg, exerts its effects through the following mechanisms:

• Analgesic (pain relief): Paracetamol inhibits cyclooxygenase (COX) enzymes, particularly COX-2, in the brain and spinal cord, which leads to reduced synthesis of prostaglandins—chemicals that cause pain and inflammation.
• Antipyretic (fever reduction): It acts on the hypothalamic heat-regulating center in the brain to reduce elevated body temperature. This effect helps the body to return to its normal thermoregulatory set point.
• Unlike NSAIDs, paracetamol does not possess significant anti-inflammatory properties and does not irritate the stomach lining or affect platelet function significantly.

This dual-action mechanism makes PANALIFE effective for managing fever and non-inflammatory pain, especially when gastrointestinal tolerance is a concern.

PANALIFE 500mg Interactions PANALIFE 500mg

Although PANALIFE 500mg is generally safe, certain drugs and substances may interact with it, potentially altering its effects or increasing the risk of side effects:

• Alcohol: Increases the risk of liver damage when used with paracetamol, especially with chronic or excessive alcohol use.
• Warfarin and other anticoagulants: Prolonged use of paracetamol can enhance the effect of these drugs, increasing the risk of bleeding.
• Carbamazepine, phenobarbital, phenytoin, rifampicin: These liver enzyme-inducing drugs may increase the risk of hepatotoxicity when taken with paracetamol.
• Isoniazid: May elevate the risk of liver toxicity.
• Cholestyramine: Can reduce the absorption of paracetamol if given within 1 hour.
• Metoclopramide or domperidone: May increase the absorption rate of paracetamol, enhancing its effect more quickly.

Always inform your healthcare provider about any medications or supplements you are taking before starting PANALIFE.

Dosage of PANALIFE 500mg

The recommended dosage of PANALIFE 500mg must be carefully followed to avoid toxicity:

• Adults and adolescents (≥12 years): 500–1000 mg (1–2 tablets) every 4 to 6 hours.
• Maximum daily dose: 4000 mg (8 tablets) in 24 hours.
• Do not take for more than 3 consecutive days without consulting a healthcare provider.
• Use the lowest effective dose for the shortest duration necessary to relieve symptoms.

Special Populations:

• Children under 12 years: Not recommended — use pediatric formulations instead.
• Elderly: No specific adjustment unless impaired liver or kidney function is present.
• Liver or kidney disease: Dose adjustment and medical supervision are required.

Do not double the dose to make up for a missed one. If symptoms persist, consult your physician.

Possible side effects of PANALIFE 500mg

PANALIFE 500mg is generally well-tolerated. However, some individuals may experience side effects, particularly with long-term use or overdose:

• Common side effects (rare at recommended doses):
  • Nausea
  • Vomiting
  • Stomach pain
• Rare but serious side effects:
  • Allergic reactions (rash, itching, swelling, dizziness, difficulty breathing)
  • Hepatotoxicity (liver damage), especially in overdose or with chronic use
  • Thrombocytopenia (low platelet count)
  • Leukopenia or neutropenia (low white blood cell counts)
• Overdose symptoms:
  • Loss of appetite
  • Jaundice (yellowing of skin/eyes)
  • Dark urine
  • Fatigue or confusion

Seek immediate medical attention if any signs of an allergic reaction or overdose occur.

PANALIFE 500mg Contraindications PANALIFE 500mg

PANALIFE 500mg should not be used in the following circumstances:

• Hypersensitivity: Known allergy to paracetamol or any inactive ingredients in the tablet.
• Severe liver disease: Including acute hepatic failure or chronic liver conditions, due to risk of toxicity.
• Severe renal impairment: In such cases, dosing must be modified or avoided.
• Alcoholism: Chronic alcohol use significantly increases the risk of liver damage from paracetamol.

Use with caution in:

• Pregnant or breastfeeding women (consult a healthcare provider)
• Patients using other medications that affect liver enzymes

Always seek medical advice before starting PANALIFE if you have underlying health conditions.

Storage of PANALIFE 500mg

Proper storage of PANALIFE ensures its safety and effectiveness:

• Store below 25°C (77°F) in a dry place, away from heat, moisture, and direct sunlight.
• Keep in the original packaging to protect from light and humidity.
• Do not store in the bathroom or other high-humidity areas.
• Keep out of reach and sight of children to prevent accidental ingestion.
• Do not use after the expiry date printed on the pack.

Dispose of expired or unused tablets responsibly. Consult your pharmacist on how to safely discard them.