PANALIFE 250mg/5ml Syrup

What is PANALIFE 250mg/5ml

PANALIFE 250mg/5ml Syrup is an oral liquid medication containing Paracetamol (also known as acetaminophen) as its active ingredient. It is primarily used to relieve mild to moderate pain and reduce fever in both children and adults.

• Each 5ml of PANALIFE Syrup contains 250mg of Paracetamol.
• It is commonly prescribed for conditions such as headaches, teething pain, muscle aches, common colds, and post-immunization fever in children.
• The syrup form allows for easier dosing, especially in pediatric patients who may have difficulty swallowing tablets.
• PANALIFE is well-tolerated and considered safe when used at recommended doses.

This formulation is typically dispensed in a 100ml glass bottle, and includes a measuring cup or spoon for accurate dosage.

How to use PANALIFE 250mg/5ml

Proper administration of PANALIFE Syrup ensures effective symptom relief while minimizing risks of side effects or overdose. Always follow the instructions provided by your healthcare provider or those printed on the packaging.

• Shake the bottle well before each use to ensure uniform distribution of the medicine.
• Measure the required dose using the provided measuring device – avoid using household teaspoons.
• Can be taken with or without food, but taking it with food may reduce the risk of stomach upset.
• Dosage frequency is usually every 4 to 6 hours as needed, but do not exceed 4 doses (or 4 grams of paracetamol) in 24 hours.
• Do not give more than the recommended dose, especially to children – overdose can lead to serious liver damage.
• If symptoms persist for more than 3 days (fever) or 5 days (pain), consult a healthcare provider.

Always read the patient information leaflet provided with the medicine for detailed instructions and safety information.

Mode of Action PANALIFE 250mg/5ml

Paracetamol, the active component of PANALIFE Syrup, is a centrally acting analgesic and antipyretic agent. Unlike nonsteroidal anti-inflammatory drugs (NSAIDs), it has minimal anti-inflammatory effects.

• It works by inhibiting prostaglandin synthesis in the brain, particularly in the hypothalamus – this leads to a reduction in the body’s set point for temperature, thereby lowering fever.
• Paracetamol also acts on the central nervous system to increase the pain threshold, offering relief from headaches, toothaches, muscle aches, and other common pain conditions.
• Its action is believed to involve inhibition of the cyclooxygenase (COX) enzyme, specifically COX-3 in the brain, although this is still under scientific investigation.
• Unlike NSAIDs, Paracetamol does not irritate the stomach lining or affect platelet function, making it a safer option for patients with gastric conditions or bleeding disorders.

Overall, PANALIFE provides fast and effective symptom relief without many of the side effects commonly associated with other pain relievers.

PANALIFE 250mg/5ml Interactions PANALIFE 250mg/5ml

While PANALIFE is generally safe, certain medications and substances may interact with Paracetamol, affecting its efficacy or increasing the risk of adverse effects.

• Alcohol: Increases the risk of liver toxicity when taken concurrently with Paracetamol.
• Warfarin and other anticoagulants: Chronic use of Paracetamol may increase the risk of bleeding.
• Enzyme-inducing drugs: Medications like carbamazepine, phenytoin, and rifampicin can enhance the metabolism of Paracetamol, potentially reducing its effectiveness and increasing hepatotoxicity risk.
• Isoniazid: When taken together, may increase the risk of liver damage.
• Cholestyramine: Can reduce the absorption of Paracetamol if taken within 1 hour of the dose.
• Metoclopramide and Domperidone: These may enhance the absorption and onset of action of Paracetamol.

Always inform your healthcare provider of any medications or supplements you are taking before using PANALIFE Syrup.

Dosage of PANALIFE 250mg/5ml

The correct dosage of PANALIFE Syrup depends on age, weight, and the severity of the symptoms. Always follow your healthcare provider’s instructions or refer to the product’s dosage guide.

• Children 1–5 years: 5ml (250mg) every 4 to 6 hours as needed.
• Children 6–12 years: 10ml (500mg) every 4 to 6 hours as needed.
• Adults and adolescents over 12 years: 10–20ml (500–1000mg) every 4 to 6 hours, not exceeding 4g in 24 hours.
• Maximum dosage: Do not exceed 60mg/kg/day in children or 4000mg/day in adults.
• Minimum interval between doses should be 4 hours.
• Do not use continuously for more than 3 days for fever or 5 days for pain without medical advice.

Accurate dosing is essential to prevent accidental overdose, especially in young children.

Possible side effects of PANALIFE 250mg/5ml

Paracetamol is generally well-tolerated, but side effects may occur in some individuals, particularly with prolonged or excessive use.

• Common side effects:
  • Nausea or mild gastrointestinal discomfort
  • Drowsiness (rare)
• Rare side effects:
  • Allergic skin reactions such as rash, itching, or urticaria
  • Liver enzyme elevation with prolonged use
• Serious (but rare) side effects:
  • Hepatotoxicity, especially with overdose
  • Severe allergic reactions (anaphylaxis)
  • Blood disorders (e.g., thrombocytopenia, leukopenia)

Seek immediate medical attention if symptoms such as swelling of the face, difficulty breathing, or yellowing of the skin/eyes occur. These may indicate serious reactions or liver damage.

PANALIFE 250mg/5ml Contraindications PANALIFE 250mg/5ml

There are specific situations where the use of PANALIFE Syrup is not advised. Always consult your doctor before use, especially in the following cases:

• Known hypersensitivity: Individuals allergic to Paracetamol or any component of the syrup should not use it.
• Severe liver disease: Patients with hepatic impairment or active liver disease should avoid Paracetamol-containing products.
• Chronic alcohol use: Increases the risk of liver damage even with therapeutic doses of Paracetamol.
• Severe renal impairment: Requires caution and dose adjustment.
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency: Use with caution as it may increase the risk of hemolysis.

Always inform your doctor of your complete medical history to ensure safe and effective use of PANALIFE Syrup.

Storage of PANALIFE 250mg/5ml

Proper storage of PANALIFE Syrup ensures its stability, effectiveness, and safety for use.

• Store the bottle at a temperature below 30°C (86°F), away from direct sunlight and moisture.
• Keep the bottle tightly closed when not in use.
• Do not freeze the syrup.
• Keep out of reach of children.
• Discard any unused portion after the expiration date indicated on the bottle or packaging.
• Do not use if the seal is broken or if the liquid appears cloudy or has changed color.

Always refer to the manufacturer's storage recommendations on the label for best practices.