PANALIFE 120mg/5ml Syrup

What is PANALIFE 120mg/5ml

PANALIFE 120mg/5ml is an oral syrup formulation containing Paracetamol (also known as Acetaminophen), a widely used analgesic (pain reliever) and antipyretic (fever reducer). It is formulated for pediatric use, but may also be prescribed for adults in specific situations where syrup formulation is preferred.

• Form: Syrup
• Strength: 120mg of paracetamol per 5ml
• Packaging: 100ml glass bottle

This medication is commonly used for:

• Reducing fever in children due to infections or after vaccinations
• Relieving mild to moderate pain, such as headache, toothache, sore throat, and musculoskeletal pain
• Managing discomfort associated with colds or flu

PANALIFE syrup is flavored for ease of administration in children and is often recommended due to its effectiveness and safety when used correctly.

How to use PANALIFE 120mg/5ml

It’s essential to follow the correct usage guidelines to ensure the safe and effective use of PANALIFE syrup:

• Shake well before use: Ensure uniform distribution of the active ingredient.
• Use an accurate dosing device: A dosing syringe or cup should be used—do not rely on household spoons.
• Administer orally: Can be given directly or mixed with a small amount of liquid if necessary.
• Can be taken with or without food: Taking with food may reduce the chance of stomach upset.

General dosing guidance (always confirm with a healthcare provider):

• Children 2–3 months: Only on medical advice, typically 2.5ml if needed for fever after vaccinations
• 3 months to 1 year: 2.5ml to 5ml every 4–6 hours
• 1–5 years: 5ml to 10ml every 4–6 hours
• Do not exceed 4 doses in 24 hours

Important: Avoid combining with other medications that contain paracetamol. If symptoms persist more than 3 days, seek medical advice.

Mode of Action PANALIFE 120mg/5ml

The therapeutic effects of PANALIFE syrup are derived from its active ingredient, paracetamol, which works through central mechanisms:

• Analgesic Action (Pain Relief):
  • Paracetamol inhibits prostaglandin synthesis in the brain, particularly in the hypothalamus and central nervous system.
  • Prostaglandins are responsible for sending pain signals; by limiting their production, pain perception is reduced.
• Antipyretic Action (Fever Reduction):
  • Paracetamol acts on the thermoregulatory center in the hypothalamus to lower elevated body temperature.
  • It promotes vasodilation and sweating, which helps the body dissipate heat.

Unlike nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol has minimal anti-inflammatory effects and does not irritate the stomach lining, making it safer for children and infants.

Its central mechanism of action allows for fast and effective symptom relief without significant gastrointestinal or platelet effects.

PANALIFE 120mg/5ml Interactions PANALIFE 120mg/5ml

Though generally considered safe, paracetamol in PANALIFE syrup can interact with other medications and substances:

• Alcohol: Increases the risk of liver toxicity when used with paracetamol, even in small amounts.
• Enzyme-inducing drugs: Such as rifampin, carbamazepine, or phenytoin may reduce paracetamol efficacy and increase liver toxicity.
• Anticoagulants (e.g., warfarin): Chronic use may enhance anticoagulant effect, increasing bleeding risk.
• Other paracetamol-containing medications: Increases the risk of overdose. Always check labels of combination products for hidden paracetamol.
• Cholestyramine: May reduce absorption of paracetamol if taken within 1 hour of PANALIFE syrup.
• Metoclopramide or domperidone: May increase absorption rate, affecting onset time.

Always inform your healthcare provider or pharmacist about all the medications your child is taking, including vitamins or herbal supplements, to avoid harmful interactions.

Dosage of PANALIFE 120mg/5ml

Correct dosing is crucial for safety and therapeutic efficacy. Dosing for PANALIFE syrup is based on the child’s age and/or weight:

• General Pediatric Dose: 10–15 mg/kg per dose every 4–6 hours as needed

Suggested age-based dosing:

• 3–6 months: 2.5ml (60mg) up to 4 times per 24 hours
• 6–12 months: 2.5–5ml (60–120mg) up to 4 times daily
• 1–5 years: 5–10ml (120–240mg) up to 4 times per day
• Maximum daily dose: Do not exceed 60mg/kg/day or 4 doses within 24 hours

Important Reminders:

• Do not exceed the recommended dose
• Always use the dosing syringe or cup provided with the medication
• If a dose is missed, do not double the next dose
• Contact a healthcare professional in case of accidental overdose

Possible side effects of PANALIFE 120mg/5ml

Most children tolerate PANALIFE syrup well. However, side effects may occur in some cases:

• Common side effects:
  • Nausea or mild stomach upset
  • Drowsiness or lethargy
• Allergic reactions (rare):
  • Skin rash or itching
  • Swelling of the face, lips, or tongue
  • Difficulty breathing (requires immediate attention)
• Serious (very rare):
  • Liver damage, especially with overdose or prolonged use
  • Hematologic disorders (e.g., thrombocytopenia, neutropenia)

If your child develops any unusual symptoms, stop using the medicine and consult a healthcare provider immediately. Regular monitoring is not usually required for short-term use.

PANALIFE 120mg/5ml Contraindications PANALIFE 120mg/5ml

PANALIFE syrup should not be used in the following situations:

• Known hypersensitivity or allergy to paracetamol or any ingredient in the formulation
• Severe liver disease or hepatic impairment as paracetamol is metabolized in the liver
• Severe renal impairment: Caution advised; dose adjustments may be necessary
• Use with caution in:
  • Children with chronic malnutrition or dehydration
  • Those taking other hepatotoxic drugs
  • Children with glucose-6-phosphate dehydrogenase (G6PD) deficiency

Always consult a pediatrician before administering any medication to infants under 3 months of age or if the child has a chronic medical condition.

Storage of PANALIFE 120mg/5ml

Proper storage ensures the medication maintains its potency and safety:

• Store at temperatures below 25°C (77°F): Keep in a cool, dry place away from direct sunlight.
• Keep in original glass bottle: Tightly closed to prevent contamination and degradation.
• Keep out of reach of children: Store in a secure location to prevent accidental ingestion.
• Do not use after the expiry date: Always check the label before administering.
• Do not refrigerate unless advised: Storing in the refrigerator may affect consistency.

Once opened, the syrup is usually good for a limited period (e.g., 6–12 months)—check manufacturer’s guidance for shelf life after opening. Discard any unused portion properly after the expiry period.