PANADREX 120mg/5ml Syrup (Sugar-free)

What is PANADREX 120mg/5ml

PANADREX 120mg/5ml is a pediatric formulation of paracetamol (also known as acetaminophen), presented in a sugar-free syrup format. It is commonly used for children to provide relief from:

• Fever (antipyretic action)
• Mild to moderate pain such as headaches, sore throat, toothache, and muscle aches
• Pain and fever associated with childhood infections (e.g., colds, flu, ear infections)

This formulation is especially suitable for children due to its:

• Liquid form: Easy to administer and swallow
• Sugar-free base: Ideal for diabetic children or those on sugar-restricted diets
• Palatable flavor: Typically flavored to ensure better compliance

Each 5ml of syrup contains 120mg of paracetamol, a widely trusted analgesic and antipyretic agent. PANADREX is available in a 100ml glass bottle and should always be dosed carefully, preferably with a calibrated measuring spoon or syringe.

How to use PANADREX 120mg/5ml

Proper administration of PANADREX ensures safety and effectiveness. The medicine should always be used under parental supervision and in accordance with dosing instructions provided by a healthcare professional or as stated on the package insert.

• Shake Well: Always shake the bottle before use to ensure even distribution of the active ingredient.
• Use a Dosing Syringe or Spoon: Avoid household spoons as they do not provide accurate dosing.
• With or Without Food: Can be taken on an empty stomach, though administering it after meals may help reduce gastrointestinal discomfort.
• Dosing Interval: Administer every 4 to 6 hours as needed.
• Maximum Doses: Do not exceed 4 doses in a 24-hour period.

General Guidelines by Age (Always confirm with a pediatrician):

• 3–12 months: 2.5–5ml
• 1–5 years: 5–10ml
• 6–12 years: 10–20ml

Do not administer for more than 3 consecutive days for fever, or 5 days for pain, unless directed by a doctor. If symptoms persist, seek medical advice.

Mode of Action PANADREX 120mg/5ml

PANADREX contains paracetamol, a centrally acting analgesic and antipyretic. It functions by modulating chemical signals in the brain that regulate temperature and pain perception.

• Analgesic (Pain-Relieving) Action:
• Inhibits cyclooxygenase (COX) enzymes in the brain, reducing the synthesis of prostaglandins—chemicals that signal pain.
• Unlike NSAIDs, paracetamol does not possess significant anti-inflammatory action in peripheral tissues.
• Antipyretic (Fever-Reducing) Action:
• Acts on the hypothalamus (body's temperature-regulating center) to induce vasodilation and sweating.
• This process increases heat loss and reduces elevated body temperature.

Onset and Duration:

• Onset of action: 30 to 60 minutes
• Peak effect: 1 to 2 hours after dosing
• Duration: Typically lasts 4–6 hours

Because PANADREX is not an anti-inflammatory medication, it’s best suited for non-inflammatory pain and uncomplicated fevers in children.

PANADREX 120mg/5ml Interactions PANADREX 120mg/5ml

Paracetamol, although generally safe when used appropriately, may interact with several drugs. These interactions can affect its efficacy or increase the risk of toxicity.

• Hepatotoxic Drugs: Medications such as isoniazid or rifampin may increase liver toxicity when used concurrently with paracetamol.
• Warfarin and Other Anticoagulants: Regular, long-term use of paracetamol may potentiate the effect of oral anticoagulants and increase bleeding risk.
• Enzyme Inducers (e.g., carbamazepine, phenytoin, barbiturates): These may reduce paracetamol’s therapeutic effect and increase liver damage risk.
• Alcohol: Concurrent use with alcohol significantly increases the risk of liver damage, even at normal doses.

Laboratory Test Interactions:

• May affect blood glucose measurements and liver function test results.

Always consult a healthcare provider if your child is taking other medications or has underlying medical conditions, especially liver-related disorders.

Dosage of PANADREX 120mg/5ml

The dosage of PANADREX syrup depends on the child’s age and weight. Always adhere to recommended dosages and consult a healthcare provider for precise dosing in infants and toddlers.

• Infants (3–12 months): 2.5ml to 5ml
• Toddlers (1–5 years): 5ml to 10ml
• Children (6–12 years): 10ml to 20ml

Dosing Instructions:

• Administer every 4–6 hours as needed
• Do not exceed 4 doses in 24 hours
• Measure using a calibrated dosing device (syringe or spoon)

For children under 3 months, consult a physician before administering. In case of overdose or accidental ingestion, seek medical help immediately—even if no symptoms are apparent, as liver damage may be delayed.

Possible side effects of PANADREX 120mg/5ml

Paracetamol is usually well tolerated, but side effects, although rare, may occur—especially in cases of overdose or prolonged use.

• Common Side Effects:
• Nausea or mild stomach upset
• Fatigue or dizziness (in higher doses)
• Rare but Serious Side Effects:
• Allergic reactions such as rash, itching, or swelling
• Breathing difficulties
• Liver damage, especially with overdose or concurrent use with alcohol

Signs of Overdose:

• Loss of appetite
• Pale skin, sweating, nausea
• Upper abdominal pain (a sign of liver injury)
• Dark urine or yellowing of skin/eyes (jaundice)

Seek immediate medical attention if any of the above occur. Allergic reactions, though rare, can be serious and require urgent care.

PANADREX 120mg/5ml Contraindications PANADREX 120mg/5ml

PANADREX should not be administered under the following conditions unless advised by a healthcare provider:

• Known hypersensitivity: Allergy to paracetamol or any syrup ingredient.
• Severe liver disease: Panadrex is metabolized in the liver and can exacerbate hepatic dysfunction.
• Children with rare hereditary problems: Such as fructose intolerance or glucose-galactose malabsorption if sweeteners are used in the formulation (check excipients).

Use with caution in:

• Children with liver impairment or history of jaundice
• Children with chronic malnutrition or dehydration
• Children on long-term medications, especially those affecting the liver

Always consult a pediatrician before administering the syrup to children under 3 months of age.

Storage of PANADREX 120mg/5ml

Proper storage is vital to maintain the medicine’s effectiveness and safety.

• Storage temperature: Store below 25°C (77°F). Do not freeze.
• Keep tightly closed: Ensure the cap is sealed properly to avoid contamination.
• Avoid sunlight: Keep away from direct heat or light sources.
• Keep out of reach of children: Store in a locked cabinet or high shelf.

After opening:

• Check the expiry date on the bottle. Do not use beyond it.
• If the syrup changes color, texture, or smell, dispose of it safely.

Do not pour unused medication down the drain. Follow local disposal guidelines or ask your pharmacist.