AIRTAL 100mg Tablets/Film-coated

What is AIRTAL 100mg

AIRTAL 100mg is a non-steroidal anti-inflammatory drug (NSAID) that contains Aceclofenac as its active ingredient. It is primarily used for the relief of pain and inflammation associated with musculoskeletal disorders. This medication is commonly prescribed for:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Lower back pain
• Toothache or dental pain
• Post-operative pain

AIRTAL helps reduce inflammation, swelling, stiffness, and joint pain, thereby improving mobility and function. It is typically provided in a 20-tablet pack (10s blister × 2) and comes in film-coated tablet form, which improves tolerability and reduces gastrointestinal discomfort.

This medication is usually recommended for short-term use, although it may be prescribed for longer durations under medical supervision. Being a prescription drug, AIRTAL should be used only under the guidance of a healthcare professional.

How to use AIRTAL 100mg

Proper administration of AIRTAL 100mg is crucial for optimal therapeutic outcomes and to minimize potential side effects. Follow your doctor’s instructions carefully when using this medication.

• Dosage: The usual adult dose is one tablet (100mg) taken twice daily — preferably morning and evening.
• Route of Administration: Oral. Swallow the tablet whole with a sufficient amount of water.
• With or without food: It is best taken after meals to minimize gastrointestinal irritation.
• Consistency: Try to take the medicine at the same times each day to maintain consistent blood levels.
• Missed Dose: If you forget a dose, take it as soon as you remember. Skip it if it’s almost time for your next dose. Do not double up to make up for a missed one.
• Duration: Use for the duration prescribed. Long-term use should be monitored for potential side effects, especially gastrointestinal or renal complications.

Important tips:

• Do not chew or crush the tablets.
• Avoid alcohol as it can increase the risk of stomach bleeding.
• Inform your doctor if you are taking other NSAIDs or blood thinners.

Mode of Action AIRTAL 100mg

AIRTAL 100mg (Aceclofenac) works by interfering with the body’s inflammatory response. Its mechanism of action is primarily centered around the inhibition of specific enzymes and the synthesis of inflammatory chemicals.

• Inhibition of Cyclooxygenase (COX): Aceclofenac selectively inhibits the enzymes COX-1 and COX-2. These enzymes are crucial in converting arachidonic acid into prostaglandins — substances that mediate pain, inflammation, and fever.
• Reduction of Prostaglandins: By decreasing prostaglandin synthesis, Aceclofenac effectively reduces pain signals, swelling, redness, and heat in the affected area.
• Peripheral Action: Unlike central analgesics, Aceclofenac acts mainly at the site of inflammation, offering targeted relief without significant central nervous system involvement.
• Anti-inflammatory and Analgesic Effects: These actions help alleviate symptoms in conditions like arthritis, enabling improved joint movement and reduced stiffness.

Advantages of Aceclofenac:

• Lower risk of gastrointestinal irritation compared to other NSAIDs like diclofenac or ibuprofen.
• Balanced COX-1/COX-2 inhibition, which minimizes risks of ulcers while maintaining anti-inflammatory effectiveness.

Due to these mechanisms, AIRTAL 100mg is highly effective in treating both acute and chronic musculoskeletal pain.

AIRTAL 100mg Interactions AIRTAL 100mg

Like all medications, AIRTAL 100mg can interact with other drugs, potentially altering its effectiveness or increasing the risk of side effects. It is essential to inform your doctor about all medications, supplements, or herbal remedies you are taking.

• Anticoagulants (e.g., Warfarin): Increased risk of bleeding.
• Other NSAIDs (e.g., Ibuprofen, Naproxen): Additive effect can heighten gastrointestinal and renal side effects.
• Corticosteroids (e.g., Prednisolone): Increased risk of gastrointestinal ulcers or bleeding.
• Antihypertensives (e.g., ACE inhibitors, ARBs, Diuretics): Reduced effectiveness; increased risk of kidney damage.
• Antidiabetics: May enhance or reduce the effects of oral antidiabetic agents; monitor blood glucose closely.
• Digoxin: May increase serum digoxin levels, leading to toxicity.
• Methotrexate: Increased risk of toxicity due to reduced renal clearance.
• Selective Serotonin Reuptake Inhibitors (SSRIs): Increased risk of gastrointestinal bleeding.

General recommendations:

• Avoid combining with alcohol or tobacco — both increase GI side effects.
• Monitor kidney and liver function if using long-term or with other nephrotoxic agents.

Dosage of AIRTAL 100mg

The dosage of AIRTAL 100mg should always be individualized based on the patient’s condition, age, and response to treatment. Below are the standard dosage guidelines:

• Adults: 100 mg twice daily (morning and evening), taken with meals to reduce gastric irritation.
• Elderly: Generally same dosage, but should be used cautiously with regular monitoring of renal and gastrointestinal function.
• Children: Not recommended in individuals under 18 years due to limited data on safety and efficacy.
• Renal or Hepatic Impairment: Dose adjustment may be necessary. Use with caution under specialist supervision.

Dosage recommendations may vary depending on:

• Severity of pain or inflammation
• Coexisting health conditions (e.g., kidney or liver disease)
• Concomitant medications

Important tips:

• Do not exceed the recommended dose.
• Monitor for any signs of GI bleeding, allergic reaction, or kidney dysfunction.
• Regular follow-up may be required for long-term users.

Possible side effects of AIRTAL 100mg

Although generally well-tolerated, AIRTAL 100mg may cause side effects, especially when used for prolonged periods or in high doses.

• Common side effects:
• Gastric discomfort or pain
• Heartburn or acid reflux
• Nausea or vomiting
• Diarrhea or constipation
• Dizziness or headache
• Less common but serious effects:
• Gastrointestinal bleeding or ulcers
• Elevated liver enzymes or liver dysfunction
• Kidney impairment
• Allergic reactions (rash, itching, swelling, especially of the face or throat)
• High blood pressure
• Rare effects:
• Stevens-Johnson syndrome
• Agranulocytosis or blood disorders
• Visual disturbances

Seek medical attention if:

• You notice black or bloody stools
• You experience persistent abdominal pain
• Signs of liver problems appear (yellowing skin/eyes, dark urine)

AIRTAL 100mg Contraindications AIRTAL 100mg

AIRTAL 100mg should not be used in certain populations due to the risk of serious adverse effects or ineffective treatment.

• Allergy: Known hypersensitivity to Aceclofenac, other NSAIDs, or any excipients in the tablet.
• Gastrointestinal conditions: Active peptic ulcer, GI bleeding, or perforation.
• Cardiovascular diseases: Severe heart failure, uncontrolled hypertension, or history of cardiovascular thrombotic events.
• Renal impairment: Severe kidney dysfunction or history of NSAID-induced nephropathy.
• Hepatic impairment: Severe liver disease or abnormal liver function tests.
• Pregnancy: Particularly contraindicated during the third trimester due to risk of ductus arteriosus closure.
• Breastfeeding: Use is not advised as it is not known whether Aceclofenac is excreted in breast milk.
• Children: Safety and efficacy not established in patients under 18 years of age.

Storage of AIRTAL 100mg

Proper storage of AIRTAL 100mg ensures its efficacy, stability, and safety over time.

• Storage temperature: Store below 30°C (86°F), in a cool and dry place away from direct sunlight and moisture.
• Container: Keep in the original blister packaging until time of use to protect from light and humidity.
• Keep out of reach of children and pets.
• Do not use: After the expiry date printed on the packaging. Expired medicine may lose potency or become harmful.
• Disposal: Do not flush unused medication down the toilet. Return it to a pharmacy for safe disposal if no longer needed.

Always check the integrity of the packaging before use. Damaged or opened blisters should be discarded.