ADOL EXTRA Tablets (Caplets)

What is ADOL EXTRA

ADOL EXTRA is a combination medication formulated in tablet (caplet) form, primarily used for relieving mild to moderate pain and reducing fever. It contains two active ingredients:

• Paracetamol: A widely used analgesic (pain reliever) and antipyretic (fever reducer) known for its effectiveness and safety profile when used correctly.
• Caffeine anhydrous: A stimulant that enhances the pain-relieving effects of paracetamol and helps reduce fatigue and increase alertness.

This medication is commonly employed to treat conditions such as headaches, muscle aches, dental pain, menstrual cramps, arthritis, and other pain-related disorders. The addition of caffeine can also improve patient tolerance by boosting the central nervous system activity, which may enhance the overall efficacy of the pain relief.

ADOL EXTRA is available in packs of 48 tablets, arranged in blister packs for convenient dosing and protection from environmental factors. Its formulation makes it suitable for adults and adolescents over a certain age, but it should always be used under medical advice, especially in people with underlying medical conditions or those taking other medications.

How to use ADOL EXTRA

Proper usage of ADOL EXTRA is critical for safety and effectiveness. Follow these guidelines:

• Dosage: Typically, adults and children over 12 years old may take one or two caplets every 4 to 6 hours as needed. Do not exceed 8 caplets in 24 hours unless advised by a healthcare professional.
• Administration: Take the tablets orally with a full glass of water. It can be taken with or without food; however, taking it with food may help reduce potential stomach upset.
• Timing: Maintain consistent intervals between doses to keep effective pain control and avoid overdose.
• Duration: Use for the shortest duration necessary to relieve symptoms. If pain or fever persists beyond 3 days or worsens, consult a healthcare provider.
• Avoid alcohol: Alcohol can increase the risk of liver damage when combined with paracetamol.
• Precautions: Inform your doctor if you have liver or kidney issues, high blood pressure, or any history of allergic reactions to paracetamol or caffeine.

Mode of Action ADOL EXTRA

The effectiveness of ADOL EXTRA stems from the complementary actions of its two active components:

• Paracetamol: Works centrally in the brain and spinal cord to reduce the sensation of pain and regulate body temperature. It inhibits the enzyme cyclooxygenase (COX), particularly COX-3 in the central nervous system, which leads to decreased production of prostaglandins—chemicals that promote pain and fever.
• Caffeine anhydrous: Acts as a central nervous system stimulant by blocking adenosine receptors. This blockage results in increased neuronal activity and the release of neurotransmitters like dopamine and norepinephrine, which contribute to enhanced alertness and mood elevation. Moreover, caffeine potentiates the analgesic effect of paracetamol, making pain relief more effective.

Together, these ingredients work synergistically: paracetamol controls pain and fever while caffeine boosts analgesic effectiveness and helps counteract fatigue, making ADOL EXTRA a balanced option for symptomatic relief.

ADOL EXTRA Interactions ADOL EXTRA

When using ADOL EXTRA, it is important to be aware of potential drug interactions that could affect its safety or effectiveness:

• Other Paracetamol-containing products: Taking multiple medicines with paracetamol can cause accidental overdose and serious liver damage.
• Anticoagulants (e.g., Warfarin): Paracetamol in high doses or prolonged use may increase bleeding risk; monitoring is advised.
• Other CNS stimulants: Concurrent use of caffeine with other stimulants (e.g., amphetamines) may increase side effects such as nervousness, insomnia, or palpitations.
• Alcohol: Increases the risk of liver toxicity with paracetamol and may intensify side effects.
• Medications metabolized by the liver (e.g., anticonvulsants, rifampin): These can affect paracetamol metabolism, altering its efficacy or toxicity risk.
• Monoamine oxidase inhibitors (MAOIs): Can interact with caffeine causing hypertensive crises or other adverse effects.

Always inform your healthcare provider about all medications and supplements you take before starting ADOL EXTRA to avoid harmful interactions.

Dosage of ADOL EXTRA

The recommended dosage for ADOL EXTRA must be carefully followed to maximize benefits and minimize risks:

• Adults and adolescents (12 years and older): One to two caplets every 4 to 6 hours as needed.
• Maximum daily dose: Do not exceed 8 caplets (equivalent to 4000 mg paracetamol and an appropriate dose of caffeine) within 24 hours.
• Children under 12: Use only under medical supervision; dosing may vary.
• Special populations: Lower doses or increased dosing intervals may be required for patients with liver or kidney impairment.
• Duration: Do not use continuously for more than 3 days without consulting a healthcare professional.

Overdose can lead to severe liver damage, which can be fatal, so adherence to the dosage instructions is essential.

Possible side effects of ADOL EXTRA

While ADOL EXTRA is generally well tolerated, some individuals may experience side effects, including:

• Common side effects: Nausea, vomiting, stomach discomfort, headache, nervousness (due to caffeine).
• Allergic reactions: Rash, itching, swelling (especially of face, tongue, or throat), severe dizziness, or difficulty breathing – require immediate medical attention.
• Liver-related issues: Prolonged or excessive use may cause elevated liver enzymes, jaundice, or liver failure in severe cases.
• Caffeine-related effects: Insomnia, restlessness, increased heart rate, palpitations, tremors, or anxiety, especially if taken in excess.
• Rare effects: Blood disorders like thrombocytopenia or leukopenia, though extremely uncommon, can occur.

If you experience any unusual symptoms or signs of an allergic reaction, stop taking the medicine and seek medical advice promptly.

ADOL EXTRA Contraindications ADOL EXTRA

ADOL EXTRA should not be used in the following conditions:

• Hypersensitivity: Known allergy or hypersensitivity to paracetamol, caffeine, or any other ingredient in the formulation.
• Severe liver impairment: Because paracetamol is metabolized by the liver, use is contraindicated in patients with severe liver dysfunction or acute liver disease.
• Severe renal impairment: Use with caution or avoid if kidney function is severely compromised.
• Certain cardiac conditions: Due to caffeine’s stimulant effect, patients with certain arrhythmias or uncontrolled hypertension should avoid this medication.
• Children under 12 years: Safety and efficacy in this group have not been established for this specific formulation.

Always consult a healthcare professional before using ADOL EXTRA if you have any chronic health issues or are pregnant or breastfeeding.

Storage of ADOL EXTRA

Proper storage ensures the medicine retains its efficacy and safety:

• Store at room temperature, ideally between 15°C to 30°C (59°F to 86°F).
• Keep the medication in its original blister packaging to protect from moisture and light.
• Store in a dry place away from direct sunlight and heat sources.
• Keep out of reach and sight of children to prevent accidental ingestion.
• Do not use the medication after the expiry date printed on the packaging.
• Dispose of unused or expired medicine responsibly, following local regulations or pharmacy guidelines.

Maintaining these conditions helps preserve the stability and effectiveness of ADOL EXTRA throughout its shelf life.