ADOL 500mg Tablets

What is ADOL 500mg

ADOL 500mg is a widely used over-the-counter medication that contains Paracetamol (also known as Acetaminophen) as its active ingredient. It is formulated in tablet form and is commonly prescribed or recommended for the relief of mild to moderate pain and fever.

• Dosage Form: Tablets
• Strength: 500mg of Paracetamol per tablet
• Packaging: 100 tablets per pack (10 tablets per blister x 10 blisters)
• Category: Analgesic and Antipyretic

ADOL 500mg is trusted for its fast-acting relief and is frequently used for conditions such as headaches, muscle aches, back pain, menstrual cramps, dental pain, and the common cold. It does not have anti-inflammatory properties and is generally well tolerated when used correctly.

This medication is available without a prescription but should still be used with care, especially regarding dosage and duration, as overdose can lead to liver damage.

How to use ADOL 500mg

ADOL 500mg should be taken according to the dosage instructions provided by a healthcare professional or as directed on the packaging. It is important to follow the recommended guidelines to ensure effectiveness and avoid side effects.

• Administration: Oral, with or without food.
• Swallow whole: Do not crush or chew the tablets unless instructed otherwise by your doctor.
• For adults and adolescents (≥12 years): Take 500mg to 1000mg every 4 to 6 hours as needed.
• Maximum dose: Do not exceed 4000mg in 24 hours.
• For children: Use a pediatric formulation; do not use adult tablets unless advised by a healthcare provider.

Always read the label before taking any medicine. Avoid combining ADOL 500mg with other products containing paracetamol to prevent overdose. If symptoms persist for more than a few days or worsen, consult a healthcare professional.

Mode of Action ADOL 500mg

Paracetamol (the active ingredient in ADOL 500mg) is a centrally acting analgesic and antipyretic agent. Unlike non-steroidal anti-inflammatory drugs (NSAIDs), it lacks significant anti-inflammatory activity.

• Analgesic effect: ADOL 500mg acts on the central nervous system (CNS) by inhibiting cyclooxygenase (COX), especially COX-2, and thereby reduces the synthesis of prostaglandins which are chemicals involved in pain perception.
• Antipyretic effect: It lowers elevated body temperature by acting on the hypothalamic heat-regulating center, enhancing heat dissipation via vasodilation and sweating.
• No anti-inflammatory action: Unlike NSAIDs, it does not significantly inhibit prostaglandin synthesis in peripheral tissues, which explains the lack of anti-inflammatory effects.
• No gastrointestinal irritation: ADOL 500mg is generally safe on the stomach lining and is preferred when NSAIDs are contraindicated.

Its unique mode of action makes it an ideal choice for pain relief and fever management in various clinical settings without the risk of gastrointestinal bleeding associated with NSAIDs.

ADOL 500mg Interactions ADOL 500mg

Although generally safe, ADOL 500mg can interact with certain medications and substances, especially when taken in high doses or over extended periods. Understanding these interactions is important to ensure safety and avoid complications.

• Alcohol: Concurrent use may increase the risk of liver toxicity. Chronic alcohol use sensitizes the liver to paracetamol-induced damage.
• Warfarin and other anticoagulants: Prolonged use of paracetamol may enhance the effect of anticoagulants and increase the risk of bleeding.
• Enzyme-inducing drugs: Medicines such as phenytoin, carbamazepine, rifampicin, and phenobarbital can increase the metabolism of paracetamol, potentially raising the risk of liver toxicity due to toxic metabolites.
• Cholestyramine: May reduce the absorption of paracetamol if taken within 1 hour.
• Metoclopramide and domperidone: These may increase the rate of paracetamol absorption and thus its onset of action.

Always inform your healthcare provider of all medications you are taking, including herbal supplements and over-the-counter drugs, to avoid adverse drug interactions.

Dosage of ADOL 500mg

The appropriate dosage of ADOL 500mg depends on age, weight, and the condition being treated. It’s important to avoid exceeding the maximum daily dose to prevent toxicity.

• Adults and adolescents (12 years and older): 500mg to 1000mg every 4 to 6 hours as needed.
• Maximum daily dose: 4000mg (8 tablets of 500mg).
• Elderly: Same as adults, but caution is advised in those with liver or kidney issues.
• Children: Not recommended in this dosage form. Use pediatric formulations with appropriate dose adjustment.
• Hepatic or renal impairment: Use with caution. Dose adjustment or extended dosing intervals may be necessary.

Do not exceed the recommended dose. Taking more than the advised amount can lead to serious liver damage, especially if combined with alcohol or other hepatotoxic agents.

Possible side effects of ADOL 500mg

ADOL 500mg is generally well tolerated, especially when used at recommended doses. However, like all medications, it can cause side effects in some individuals.

• Common: Usually none at therapeutic doses.
• Rare but serious:
  • Allergic reactions such as skin rash, itching, or swelling
  • Angioedema (swelling of the face, lips, or throat)
  • Difficulty breathing (anaphylaxis)
• Hematological: Blood disorders like thrombocytopenia or neutropenia have been rarely reported.
• Hepatic toxicity: Overdose may cause severe liver damage which may not be apparent immediately (symptoms may take 24-72 hours to appear).
• Renal effects: Long-term use of high doses may potentially impair kidney function.

If any unusual symptoms occur after taking ADOL, especially signs of an allergic reaction or jaundice (yellowing of the skin/eyes), seek medical attention promptly.

ADOL 500mg Contraindications ADOL 500mg

Although considered safe for most people, ADOL 500mg should not be used in certain situations. It’s crucial to review the contraindications before initiating therapy.

• Hypersensitivity: Known allergy to paracetamol or any of the excipients in the formulation.
• Severe liver disease: Due to the risk of hepatotoxicity, paracetamol is contraindicated in patients with severe hepatic impairment or active liver disease.
• Severe renal impairment: Caution is advised, and use may be restricted in severe cases depending on creatinine clearance levels.
• Chronic alcoholism: Individuals with a history of alcohol abuse are at higher risk of liver injury and should avoid use unless advised by a physician.

Always consult a healthcare professional if you are unsure whether ADOL 500mg is safe for you, particularly if you have pre-existing medical conditions or are taking other medications.

Storage of ADOL 500mg

Proper storage of ADOL 500mg is essential to maintain its effectiveness and safety. Follow these guidelines to ensure the medication remains in good condition:

• Temperature: Store at room temperature (below 25°C or 77°F).
• Humidity: Keep in a dry place away from excess moisture or humidity (e.g., avoid storing in a bathroom).
• Light: Protect from direct sunlight and strong artificial light.
• Original packaging: Keep tablets in their original blister pack until use to protect them from environmental exposure.
• Keep out of reach of children: Store in a secure location to avoid accidental ingestion.

Do not use the medicine beyond its expiry date. Safely dispose of any unused or expired medication according to local regulations or return it to a pharmacy.