ADOL 500mg Tablets

What is ADOL 500mg

ADOL 500mg is a widely used analgesic and antipyretic medication, containing the active ingredient Paracetamol (also known as acetaminophen). It is commonly prescribed or purchased over-the-counter to manage mild to moderate pain and to reduce fever.

• Dosage form: Tablet
• Strength: 500mg of Paracetamol per tablet
• Packaging: 50 tablets (10 tablets per blister, 5 blisters)
• ATC Classification: N02BE01 – Anilides

Paracetamol is a trusted medication for a variety of everyday health issues, including headaches, dental pain, menstrual cramps, muscular aches, and conditions associated with fever such as the common cold or flu. Unlike NSAIDs (non-steroidal anti-inflammatory drugs), Paracetamol does not cause gastric irritation and is safer for use in individuals with gastrointestinal sensitivity.

• Suitable for both adults and children (in age-appropriate doses)
• Often recommended when NSAIDs like ibuprofen or aspirin are contraindicated
• Generally well tolerated when used at recommended doses

ADOL 500mg is a popular brand of Paracetamol and is often chosen for its reliability and rapid onset of action in relieving pain and reducing body temperature. However, it is important to use it responsibly to avoid overdose or liver-related complications.

How to use ADOL 500mg

ADOL 500mg tablets should be used exactly as directed by your physician or pharmacist. For over-the-counter use, carefully follow the directions on the product label or package insert. This ensures maximum effectiveness and safety.

• Route of administration: Oral
• Timing: Can be taken with or without food, though taking it with food may reduce the risk of stomach upset

General usage guidelines:

• Swallow the tablet whole with a glass of water.
• Do not crush or chew unless advised by a doctor or pharmacist.
• Allow at least 4 to 6 hours between doses.
• Do not exceed the recommended daily dose (generally 4,000mg or 8 tablets per day for adults, unless otherwise instructed).

Special instructions:

• For chronic conditions (e.g., osteoarthritis), it may be used under medical supervision for longer durations.
• In children, the dosage is based on age and weight. Always follow pediatric dosing instructions.
• If a dose is missed, take it as soon as remembered unless it's almost time for the next dose. Do not double the dose to catch up.

Warnings:

• Do not use with other products containing Paracetamol to avoid overdose.
• Check all medications (including cough and cold products) to ensure they do not also contain Paracetamol.
• If symptoms persist for more than 3 days for fever or 5 days for pain, consult a doctor.

Mode of Action ADOL 500mg

Paracetamol, the active component in ADOL 500mg, exhibits analgesic (pain-relieving) and antipyretic (fever-reducing) properties. Unlike NSAIDs, Paracetamol has minimal anti-inflammatory activity.

Mechanism of action includes:

• Centrally acting analgesic: Paracetamol primarily acts on the central nervous system (CNS). It inhibits cyclooxygenase (COX) enzymes, particularly COX-2, in the brain and spinal cord. This inhibition leads to reduced synthesis of prostaglandins—compounds that signal pain and fever.
• Antipyretic effect: Paracetamol affects the hypothalamic heat-regulating center, causing the body to dissipate heat through sweating and vasodilation, which lowers fever.
• Minimal peripheral activity: It has little to no effect on COX enzymes in peripheral tissues, which explains the absence of anti-inflammatory effects and minimal gastric irritation.

Pharmacokinetics:

• Onset of action: 30 to 60 minutes after oral administration
• Duration: 4 to 6 hours
• Metabolism: Primarily metabolized in the liver via glucuronidation and sulfation
• Excretion: Excreted by the kidneys

Due to its centrally mediated effects and minimal gastrointestinal involvement, Paracetamol is a safer option for many individuals, including those with peptic ulcer disease or aspirin sensitivity.

ADOL 500mg Interactions ADOL 500mg

While ADOL 500mg is generally safe when used alone, it may interact with certain other medications, potentially affecting how either drug works or increasing the risk of side effects.

Major drug interactions include:

• Alcohol: Chronic alcohol consumption increases the risk of liver toxicity when combined with Paracetamol.
• Warfarin and other anticoagulants: Long-term use of Paracetamol may enhance the effect of warfarin, increasing bleeding risk.
• Carbamazepine, phenytoin, rifampicin: These drugs induce liver enzymes and may increase the hepatotoxicity of Paracetamol by promoting its conversion to toxic metabolites.
• Isoniazid: When used together, there's an increased risk of liver injury.
• Cholestyramine: May reduce the absorption of Paracetamol if taken within 1 hour.
• Metoclopramide or domperidone: May increase the absorption rate of Paracetamol, leading to a quicker onset of action.

Precautionary advice:

• Always inform your doctor or pharmacist about all medications you are taking, including herbal and over-the-counter products.
• Avoid combining multiple medications containing Paracetamol.
• In patients on long-term therapy with hepatotoxic drugs, careful monitoring is advised.

Dosage of ADOL 500mg

Dosage of ADOL 500mg should be carefully adjusted based on age, weight, and medical condition. It is essential not to exceed the maximum recommended dose to prevent the risk of serious liver damage.

Typical dosage guidelines:

• Adults and children ≥12 years: 500mg to 1000mg (1 to 2 tablets) every 4–6 hours as needed. Do not exceed 4000mg (8 tablets) in 24 hours.
• Children 6–12 years: Typically 250–500mg every 4–6 hours. Do not exceed 2000–3000mg daily. Use pediatric-specific products if available.
• Children under 6 years: Use only pediatric formulations. Tablets are not recommended unless directed by a physician.

Special considerations:

• In hepatic impairment: Use lower doses and monitor liver function.
• In renal impairment: Dose adjustment may be required based on creatinine clearance.
• Elderly: Use with caution due to possible liver sensitivity; monitor hepatic function.

Missed doses can be taken when remembered unless it’s near the next scheduled dose. Avoid doubling up. Always consult with a healthcare provider before initiating or adjusting the dosage.

Possible side effects of ADOL 500mg

Paracetamol (ADOL 500mg) is generally well-tolerated when used as recommended. However, like all medications, it can cause side effects in some individuals, especially when taken in high doses or for prolonged periods.

Common side effects (rare in normal use):

• Nausea
• Vomiting
• Mild abdominal discomfort

Serious but rare side effects:

• Allergic reactions: Rash, itching, swelling (especially of the face/tongue/throat), dizziness, or difficulty breathing (anaphylaxis)
• Liver toxicity: Especially with overdose or prolonged use – signs include yellowing of the skin or eyes (jaundice), dark urine, or abdominal pain
• Blood disorders: Thrombocytopenia, neutropenia (uncommon)

Overdose warning:

• Paracetamol overdose is serious and can be fatal due to acute liver failure.
• Early symptoms: Nausea, vomiting, loss of appetite, sweating, confusion
• If overdose is suspected, seek emergency medical help immediately, even in the absence of symptoms.

ADOL 500mg Contraindications ADOL 500mg

While Paracetamol is generally safe, there are specific situations in which ADOL 500mg should not be used. These contraindications are important to prevent potential harm or worsening of pre-existing health conditions.

Absolute contraindications:

• Known hypersensitivity or allergy to Paracetamol or any component of the formulation
• Severe hepatic impairment or active liver disease

Relative contraindications (use with caution):

• Chronic alcohol abuse or dependence
• Severe renal impairment
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency
• Malnutrition (which may increase the risk of hepatotoxicity)

Pregnancy and lactation:

• Generally considered safe during pregnancy when used in recommended doses
• Paracetamol is excreted in breast milk in small amounts; considered safe for nursing mothers

Storage of ADOL 500mg

Proper storage of medications ensures their effectiveness and prevents accidental ingestion, especially by children. ADOL 500mg should be stored as follows:

• Temperature: Store below 25°C (77°F). Avoid exposure to excessive heat or direct sunlight.
• Humidity: Keep in a dry place. Avoid storing in bathrooms or other humid environments.
• Packaging: Keep the tablets in their original blister packaging until use to protect them from moisture and light.
• Keep out of reach of children: Paracetamol overdose can be fatal, particularly in young children.
• Do not use: After the expiration date printed on the packaging. Expired medications may be ineffective or harmful.

Follow local guidelines for safe disposal of unused or expired medication. Do not flush medications down the toilet unless instructed to do so.