ADOL 250mg/5ml Suspension

What is ADOL 250mg/5ml

ADOL 250mg/5ml Suspension is a pediatric-friendly liquid formulation of the widely used analgesic and antipyretic medication Paracetamol (also known as Acetaminophen). It is specially designed for children and is typically used to reduce fever and relieve mild to moderate pain.

• Active Ingredient: Paracetamol 250mg per 5ml
• Dosage Form: Oral suspension
• Packaging: 100ml Glass Bottle

This formulation is favored for children due to its ease of administration, palatable taste, and accurate dosing using a spoon or oral syringe. It is commonly prescribed for:

• Reducing fever caused by infections such as colds, flu, or post-vaccination reactions
• Relieving pain due to teething, sore throat, headaches, earaches, or muscle aches
• Managing mild pain associated with childhood illnesses

Paracetamol is considered safe and effective when used correctly and at recommended doses. It is available over-the-counter but should still be used under medical supervision for children, especially for prolonged periods or high doses. ADOL suspension is well-tolerated and does not typically irritate the stomach, unlike some NSAIDs.

How to use ADOL 250mg/5ml

Proper use of ADOL 250mg/5ml Suspension is essential for achieving the desired therapeutic effects while minimizing risks. Always follow your doctor’s instructions or the label directions on the packaging.

• Shake well before use: The suspension must be shaken thoroughly to ensure even distribution of the medication in each dose.
• Measure accurately: Use a calibrated measuring spoon, dropper, or oral syringe. Avoid using kitchen teaspoons as they may cause inaccurate dosing.
• Administer orally: This medicine is taken by mouth and can be given with or without food.

General Dosing Guidance:

• Children 6–12 years: 5–10ml (250–500mg) every 4–6 hours as needed
• Do not exceed 4 doses in 24 hours
• Children under 6 years: Use under strict medical advice

Important Usage Notes:

• Do not exceed the recommended dose; overdose can lead to liver damage.
• Consult your healthcare provider if symptoms persist beyond 3 days or worsen.
• If a dose is missed, give it as soon as you remember unless it is almost time for the next dose.

In cases of accidental overdose, seek medical attention immediately, even if the child appears well, due to potential delayed liver injury.

Mode of Action ADOL 250mg/5ml

ADOL Suspension contains Paracetamol, a medication known for its analgesic (pain-relieving) and antipyretic (fever-reducing) properties. Although its exact mechanism of action is not entirely understood, several well-studied pathways explain how it works in the body.

• Central Inhibition of Prostaglandin Synthesis: Paracetamol primarily acts on the central nervous system (CNS) by inhibiting the enzyme cyclooxygenase (COX), particularly COX-2, which is involved in prostaglandin production. Prostaglandins are chemicals that cause inflammation, pain, and fever.
• Antipyretic Effect: It acts on the hypothalamic heat-regulating center in the brain. When body temperature is elevated due to infection or inflammation, paracetamol helps to lower it by inhibiting the synthesis of pyrogens (fever-inducing chemicals).
• No Significant Anti-inflammatory Activity: Unlike NSAIDs, paracetamol has little peripheral anti-inflammatory action because it does not inhibit COX in inflamed tissues effectively. This makes it suitable for children and individuals who are sensitive to NSAID side effects.

Benefits of This Mechanism:

• Safe for stomach and kidneys when used correctly
• Less risk of gastrointestinal side effects compared to NSAIDs
• Fast onset of action—usually works within 30 minutes

Overall, ADOL Suspension is highly effective for treating fever and mild to moderate pain in pediatric patients, making it a trusted choice in both home and clinical settings.

ADOL 250mg/5ml Interactions ADOL 250mg/5ml

Paracetamol (the active ingredient in ADOL Suspension) is generally well-tolerated and has a relatively low interaction profile. However, certain medications and substances may influence its safety and efficacy.

Potential Drug Interactions:

• Warfarin and other anticoagulants: Chronic use of paracetamol may enhance the effects of anticoagulants, increasing the risk of bleeding. Occasional use is generally safe.
• Carbamazepine, Phenytoin, and Barbiturates: These drugs can enhance liver enzyme activity, potentially increasing the toxic metabolites of paracetamol, leading to liver damage.
• Rifampin and Isoniazid: May increase the hepatotoxicity of paracetamol, particularly with high doses or prolonged use.
• Alcohol: Chronic alcohol use can significantly increase the risk of liver damage when combined with paracetamol, even at therapeutic doses.

Laboratory Test Interference:

• Paracetamol may interfere with blood glucose monitoring and liver function tests in rare instances.

General Advice:

• Always inform your healthcare provider of all medications, supplements, or herbal products your child is taking.
• Avoid combining with other over-the-counter cold or flu medications that may also contain paracetamol to prevent unintentional overdose.

Dosage of ADOL 250mg/5ml

The correct dosage of ADOL Suspension depends on the child’s weight, age, and the severity of symptoms. Below is a general dosing guide, but individual recommendations from a healthcare professional should always be followed.

General Pediatric Dosing (by Age):

• 6–12 years: 5–10ml (250–500mg) every 4–6 hours as needed
• 4–6 years: 2.5–5ml (125–250mg) every 4–6 hours as needed
• 2–4 years: 2.5ml (125mg) every 4–6 hours as needed
• Do not exceed: 4 doses in 24 hours

Weight-Based Dosing (Preferred for Accuracy):

• 10–15mg/kg per dose, every 4–6 hours
• Maximum daily dose: 60mg/kg/day in divided doses

Dosage Precautions:

• Never exceed the recommended daily dose
• Use for a maximum of 3 days for fever or 5 days for pain unless advised by a doctor
• Seek immediate medical attention in case of overdose

Proper measuring tools should be used, and dosing should be adjusted based on clinical judgment and patient response.

Possible side effects of ADOL 250mg/5ml

Paracetamol is generally safe when used as directed, especially in pediatric formulations like ADOL Suspension. However, as with all medications, some side effects may occur.

Common Side Effects (usually mild):

• Nausea
• Stomach upset or discomfort
• Mild rash or itching (due to excipients or flavorings)

Rare but Serious Side Effects:

• Allergic reactions: Swelling of the face, lips, or tongue, difficulty breathing, and hives. Discontinue use and seek emergency help immediately.
• Liver toxicity: Especially with overdose or prolonged use. Symptoms include yellowing of skin/eyes (jaundice), nausea, fatigue, and dark urine.

Long-Term Use Risks:

• Liver damage (hepatotoxicity) due to accumulation of toxic metabolites
• Kidney damage in rare cases with chronic high dosing

Important Notes:

• Always use the appropriate dose for your child's age and weight
• If any unusual symptoms occur, stop using the product and consult a doctor

ADOL 250mg/5ml Contraindications ADOL 250mg/5ml

While ADOL Suspension is widely used in pediatric care, there are specific situations in which its use is contraindicated or should be carefully evaluated by a healthcare provider.

• Hypersensitivity to Paracetamol: Children with known allergies to paracetamol or any component of the suspension should not use this medicine.
• Severe Liver Impairment: Avoid use in children with liver failure or severe hepatic dysfunction, as paracetamol is metabolized in the liver and can worsen liver injury.
• Active Alcoholism (in adolescents): Chronic alcohol use can potentiate the hepatotoxic effects of paracetamol, even at therapeutic doses.

Relative Contraindications (Caution Advised):

• Children with known enzyme deficiencies affecting paracetamol metabolism (e.g., G6PD deficiency)
• Severe renal impairment – dosing adjustment may be required

Drug-Related Cautions:

• Do not co-administer with other paracetamol-containing medications

Careful history-taking and proper diagnosis are essential before initiating treatment with ADOL in special populations.

Storage of ADOL 250mg/5ml

Proper storage of ADOL Suspension ensures its efficacy, safety, and shelf-life.

• Storage Temperature: Store at below 25°C (77°F). Do not refrigerate or freeze.
• Protect from Light: Store in the original glass bottle and keep tightly closed to protect from light and moisture.
• Keep Out of Reach of Children: Always store in a secure place, preferably in a childproof cabinet.

Handling Instructions:

• Shake the bottle well before each use
• Do not use after the expiry date printed on the packaging
• Use within the period indicated on the label after opening (typically 6–12 months)

Proper disposal of unused or expired medication is essential. Do not pour into wastewater or throw into household waste; consult your pharmacist for safe disposal practices.