ADOL 250mg Rectal Suppositories

What is ADOL 250mg

ADOL 250mg Rectal Suppositories contain Paracetamol (also known as Acetaminophen), a widely used analgesic and antipyretic medication. This formulation is designed for rectal administration, offering an alternative to oral intake—particularly helpful in pediatric or vomiting patients.

• Active Ingredient: Paracetamol 250mg
• Dosage Form: Rectal Suppositories
• Packaging: 10 suppositories (2 blister strips of 5 each)
• Therapeutic Class: Analgesic and Antipyretic

ADOL suppositories are commonly used to relieve:

• Fever due to infections, immunizations, or inflammatory conditions
• Mild to moderate pain including headaches, sore throat, earache, or post-surgical discomfort

This rectal form bypasses the digestive system, making it suitable for patients who are nauseous, unconscious, or unable to swallow. It is primarily prescribed for children, but it may be used in adults based on clinical judgment.

How to use ADOL 250mg

ADOL 250mg Rectal Suppositories should be used as directed by a healthcare professional. It is essential to follow instructions closely to ensure both safety and efficacy.

General Steps for Administration:

1. Wash your hands thoroughly with soap and water.
2. Remove the suppository from its plastic wrapper without cutting or breaking it.
3. If the suppository is too soft to insert, refrigerate it for a few minutes or run it under cold water while still in the wrapper.
4. Lie on your side with the upper leg pulled toward your chest (for children, lying on the back with legs raised may be preferred).
5. Gently insert the suppository, pointed end first, into the rectum using your finger. Push it in far enough so it won’t come out.
6. Remain lying down for a few minutes to allow absorption.
7. Wash hands again after use.

Important Usage Tips:

• Do not use more than the recommended dose or frequency.
• Do not split or crush the suppository.
• Store unused suppositories as instructed (usually in a cool place).
• Only for rectal use – do not ingest orally.

Mode of Action ADOL 250mg

Paracetamol, the active ingredient in ADOL 250mg, works primarily in the central nervous system. Though its complete mechanism is not fully understood, its analgesic and antipyretic effects are well documented.

Pharmacodynamic Actions:

• Analgesic effect: Inhibits the cyclooxygenase (COX) pathway in the brain, reducing prostaglandin synthesis, which plays a role in pain perception.
• Antipyretic effect: Acts on the hypothalamic heat-regulating center, helping lower elevated body temperature through vasodilation and increased peripheral blood flow.

Key Characteristics:

• Does not have significant anti-inflammatory action like NSAIDs.
• Has minimal gastrointestinal side effects compared to NSAIDs since it does not strongly inhibit peripheral COX enzymes.
• Well absorbed and effective within 30 minutes to 1 hour after rectal administration.

Thus, ADOL 250mg is especially useful for treating fever and mild pain, particularly in cases where oral administration is not feasible.

ADOL 250mg Interactions ADOL 250mg

Although Paracetamol is generally well tolerated and has a favorable interaction profile, it can interact with certain medications. Being aware of these interactions is essential to avoid adverse effects or reduced effectiveness.

Drugs that may interact with ADOL (Paracetamol):

• Warfarin and other anticoagulants: Regular use of Paracetamol may increase bleeding risk due to potential enhancement of anticoagulant effect.
• Alcohol: Concurrent use can increase the risk of liver toxicity, especially with chronic alcohol consumption.
• Rifampicin, Carbamazepine, Phenytoin: These drugs induce liver enzymes and may accelerate the breakdown of Paracetamol, reducing its effectiveness and potentially increasing the risk of liver damage.
• Cholestyramine: May reduce absorption of Paracetamol if given simultaneously. A time gap of at least 1 hour is recommended.
• Metoclopramide and Domperidone: May increase the rate of Paracetamol absorption by accelerating gastric emptying.

Always inform your healthcare provider about all prescription, over-the-counter medications, and supplements you are taking before starting ADOL suppositories.

Dosage of ADOL 250mg

ADOL 250mg suppositories should be used under medical supervision, especially in children. The dose varies depending on age, weight, and the condition being treated.

Recommended Dosage Guidelines:

• Children 6–12 years: One suppository (250mg) every 4–6 hours as needed. Do not exceed 4 doses in 24 hours.
• Adults and older children: Can be used at the same dosing interval if recommended by a healthcare provider, though a higher strength may be more appropriate.

Important Considerations:

• Do not exceed a total of 60mg/kg/day for children unless directed by a physician.
• Space doses evenly throughout the day.
• Consult a doctor if fever persists beyond 3 days or pain continues for more than 5 days.

Overdosing on Paracetamol, even accidentally, can cause severe liver damage. Always use a precise dosing schedule and consult a healthcare provider when in doubt.

Possible side effects of ADOL 250mg

While ADOL (Paracetamol) is generally well tolerated, some individuals may experience side effects, particularly with prolonged or high-dose usage.

Common Side Effects:

• Mild rectal irritation or discomfort
• Nausea (less likely in rectal form)
• Drowsiness or tiredness in rare cases

Rare but Serious Side Effects:

• Allergic reactions: Rash, itching, swelling (especially of the face/tongue/throat), dizziness, or breathing difficulty
• Hepatotoxicity: Overdose can lead to liver damage. Early symptoms include nausea, vomiting, loss of appetite, and abdominal pain.
• Blood disorders: Rare conditions like thrombocytopenia or leukopenia

If any signs of serious reactions appear, stop the medication and seek immediate medical attention. Monitoring is especially important when used with other medications or in patients with liver conditions.

ADOL 250mg Contraindications ADOL 250mg

ADOL 250mg should not be used in certain medical situations or in individuals with known hypersensitivity to its components.

Absolute Contraindications:

• Known allergy to Paracetamol or any component of the suppository
• Severe liver impairment or active liver disease
• Rectal conditions: Hemorrhoids, proctitis, or rectal bleeding, where suppository use could worsen symptoms

Relative Contraindications (Use with Caution):

• History of alcohol abuse or chronic alcohol consumption
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency
• Malnutrition or dehydration (increased risk of hepatotoxicity)

Always consult a healthcare provider before starting the medication, especially in children under 6 years or in patients with preexisting liver conditions.

Storage of ADOL 250mg

Proper storage of ADOL suppositories is essential to maintain effectiveness and safety.

Storage Guidelines:

• Store at a temperature below 25°C (77°F).
• Do not freeze, as freezing may alter the texture or integrity of the suppository.
• Keep in the original packaging to protect from light and moisture.
• Ensure the blister is intact before use. Do not use if packaging is damaged or expired.

Handling Tips:

• Keep out of reach of children.
• Suppositories can melt in warm conditions; if softened, refrigerate before use.
• Check expiry date regularly and dispose of expired products safely.

Proper storage ensures the suppositories remain firm and effective at the time of use, minimizing risks of degradation or reduced efficacy.