ADOL 125mg Rectal Suppositories

What is ADOL 125mg

ADOL 125mg Rectal Suppositories contain the active ingredient Paracetamol, a widely used analgesic (pain reliever) and antipyretic (fever reducer). This form of administration is particularly helpful for pediatric patients or individuals who cannot take oral medications due to nausea, vomiting, or swallowing difficulties.

• Form: Rectal Suppositories
• Strength: 125mg Paracetamol per suppository
• Pack Size: 100 suppositories (5 suppositories per blister x 20 blisters)
• Therapeutic Class: Analgesics/Antipyretics
• Target Use: Relief of mild to moderate pain and reduction of fever

ADOL suppositories offer a convenient and effective way to manage symptoms in children or patients who are unconscious or experiencing gastrointestinal disturbances. They are often used in pediatric medicine but can also be suitable for adults under specific conditions. The product ensures systemic absorption through the rectal mucosa, bypassing first-pass liver metabolism to some extent, making it a valuable alternative when oral or intravenous routes are not feasible.

Common indications include:

• Fever due to infection, post-immunization, or unknown causes
• Teething-related discomfort in infants
• Headache or earache
• Post-operative or injury-related pain

It is generally well-tolerated and considered safe when used at the recommended doses. However, as with any medication, proper usage guidelines should be followed, and healthcare provider consultation is advisable for prolonged use or high fever.

How to use ADOL 125mg

Using ADOL 125mg Rectal Suppositories correctly ensures optimal relief and minimizes risks. This form is primarily used in pediatric care or when oral administration is not possible.

Instructions for Use:

• Step 1: Prepare the suppository
  Wash your hands with soap and water. Remove one suppository from the blister packaging without crushing or breaking it.
• Step 2: Position the patient
  For infants and children, gently lay the child on their side or stomach with knees pulled toward the chest. This position eases insertion and prevents premature expulsion.
• Step 3: Insert the suppository
  Lubricate the tip with water or a water-based lubricant (if needed). Gently insert the suppository pointed-end first into the rectum using your finger. Push it in far enough to prevent it from slipping out.
• Step 4: Allow time for absorption
  Keep the patient lying down for a few minutes to allow the suppository to stay in place. Avoid using the bathroom immediately after administration.

Usage Tips:

• Follow dosing intervals strictly—typically every 4 to 6 hours.
• Do not use more than the recommended number of doses per 24 hours (usually 4 doses max).
• Ensure the full course is used if recommended for managing fever or pain.
• Never cut suppositories unless advised by a physician, as the medication may not be evenly distributed.

Always consult a healthcare provider for dosing in infants under 3 months or for repeated use beyond a few days.

Mode of Action ADOL 125mg

Paracetamol, the active ingredient in ADOL 125mg Rectal Suppositories, acts primarily as an analgesic and antipyretic agent. Although it is not classified as a nonsteroidal anti-inflammatory drug (NSAID), it provides effective pain and fever relief with minimal gastrointestinal side effects.

Mechanism of Action:

• Central inhibition of prostaglandin synthesis: Paracetamol inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, in the central nervous system (CNS). This reduces prostaglandin production, which helps in lowering fever and alleviating pain.
• Thermoregulatory action in the hypothalamus: In febrile states, Paracetamol resets the hypothalamic temperature-regulating center, promoting heat dissipation through vasodilation and sweating, effectively reducing body temperature.
• Minimal peripheral activity: Unlike NSAIDs, Paracetamol has minimal anti-inflammatory action at peripheral sites due to limited inhibition of prostaglandin synthesis outside the CNS. This reduces the risk of gastrointestinal or renal adverse effects.

Onset and Duration:

• Onset of action: 30 to 60 minutes after rectal administration
• Duration of action: 4 to 6 hours

Because the rectal route partly bypasses first-pass metabolism, it can maintain adequate systemic levels, especially in children with poor oral intake. However, absorption may be slower and somewhat variable compared to oral forms, depending on rectal contents and perfusion.

ADOL 125mg Interactions ADOL 125mg

Paracetamol generally has a favorable interaction profile, but concurrent use with certain drugs can either reduce its efficacy or increase the risk of toxicity.

Common Drug Interactions:

• Warfarin and other anticoagulants: Prolonged use of Paracetamol may enhance the effect of coumarin-type anticoagulants, increasing the risk of bleeding. Occasional use has minimal effect.
• Carbamazepine, Phenytoin, Phenobarbital: These antiepileptics can induce liver enzymes, potentially increasing the formation of toxic Paracetamol metabolites and raising the risk of hepatotoxicity.
• Isoniazid and Rifampin: Can increase hepatotoxic risk when used with Paracetamol due to enhanced metabolism into toxic intermediates.
• Alcohol: Chronic alcohol use can increase susceptibility to liver damage with therapeutic doses of Paracetamol.
• Cholestyramine: May reduce the absorption of Paracetamol if given shortly after its administration.
• Metoclopramide and Domperidone: These drugs can increase the rate of absorption of Paracetamol when administered together due to enhanced gastric emptying.

Precautionary Advice:

• Always inform your healthcare provider about all medications and supplements being used.
• Avoid alcohol during treatment to reduce the risk of liver toxicity.
• Monitor liver function in patients using long-term Paracetamol or those on hepatotoxic drugs.

Dosage of ADOL 125mg

The dosage of ADOL 125mg Rectal Suppositories depends on the age and weight of the patient. It is primarily used in children, and healthcare providers should always determine the exact dose for neonates and infants.

Recommended Dosage Guidelines:

• Children (1 to 5 years): One suppository (125mg) every 4 to 6 hours as needed, not exceeding 4 doses (500mg) in 24 hours.
• Infants (6 months to 1 year): Use only under medical supervision. Usually 60–125mg every 6–8 hours.
• Neonates: Not recommended without specialist consultation.

General Administration Advice:

• Do not exceed a total daily dose of 60mg/kg/day unless advised by a physician.
• Ensure appropriate interval (4–6 hours) between doses.
• If a dose is missed and symptoms persist, it may be administered as long as the minimum interval is respected.
• Seek medical advice if fever or pain persists beyond 3 days of use.

Dosage adjustment may be required for children with hepatic or renal impairment.

Possible side effects of ADOL 125mg

Paracetamol is usually well tolerated, especially in standard doses. However, rectal administration can occasionally cause local and systemic side effects.

Common Side Effects:

• Rectal discomfort or irritation – including a sensation of burning or the urge to defecate
• Nausea or abdominal discomfort – uncommon with suppository use but possible

Rare but Serious Side Effects:

• Allergic reactions: Rash, itching, swelling (especially of face/tongue/throat), dizziness, or difficulty breathing
• Hepatotoxicity: In overdose or with prolonged high dosing, liver damage may occur
• Blood disorders: Thrombocytopenia, leukopenia (extremely rare)

Signs of Overdose (Seek Immediate Medical Help):

• Nausea, vomiting, loss of appetite
• Confusion or unusual tiredness
• Yellowing of skin or eyes (jaundice)

To minimize risk, always use the correct dosage and consult a doctor for any prolonged or concerning symptoms.

ADOL 125mg Contraindications ADOL 125mg

Although Paracetamol is generally considered safe, certain medical conditions and situations may contraindicate the use of ADOL 125mg suppositories.

Absolute Contraindications:

• Known hypersensitivity: Allergy to Paracetamol or any excipients in the suppository formulation
• Severe hepatic impairment or active liver disease: Risk of worsening hepatotoxicity

Relative Contraindications (Caution Advised):

• Rectal inflammation or lesions: Conditions like proctitis, rectal bleeding, or hemorrhoids may worsen with rectal administration
• Chronic malnutrition or alcohol abuse: Increased risk of liver toxicity even with standard dosing
• Severe renal impairment: Dose adjustment may be required

Special Populations:

• Neonates: Use under strict medical supervision only
• Pregnant or breastfeeding women: Generally considered safe at therapeutic doses, but rectal form is less studied

Storage of ADOL 125mg

Proper storage of ADOL 125mg suppositories ensures the product remains effective and safe for use throughout its shelf life.

Storage Guidelines:

• Temperature: Store below 25°C (77°F), away from direct sunlight and heat
• Humidity: Keep in a dry place; do not store in the bathroom or near sinks
• Packaging: Keep the suppositories in their original blister packaging until use to avoid degradation

Handling Tips:

• Check the expiry date before use
• Do not use if the suppository appears discolored, melted, or misshapen
• Refrigeration is not usually required but may be helpful in hot climates (consult the pharmacist)

Disposal:

• Discard unused or expired suppositories safely
• Do not flush medications down the toilet or pour into drains unless instructed

Keep all medications out of reach of children and pets.